ENSMUSG00000004654


Mus musculus

Features
Gene ID: ENSMUSG00000004654
  
Biological name :Ghrhr
  
Synonyms : Ghrhr / Growth hormone-releasing hormone receptor / P32082
  
Possible biological names infered from orthology : Q02643
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: B3
Gene start: 55376295
Gene end: 55388530
  
Corresponding Affymetrix probe sets: 10538466 (MoGene1.0st)   1427611_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145224
Ensembl peptide - ENSMUSP00000068120
NCBI entrez gene - 14602     See in Manteia.
MGI - MGI:95710
RefSeq - NM_001003685
RefSeq Peptide - NP_001003685
swissprot - A0A0N4SVS4
swissprot - P32082
Ensembl - ENSMUSG00000004654
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ghrhr2ENSDARG00000099218Danio rerio
 ghrhraENSDARG00000104961Danio rerio
 ghrhrbENSDARG00000053708Danio rerio
 GHRHRENSGALG00000005212Gallus gallus
 GHRHRENSG00000106128Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vipr1 / P97751 / vasoactive intestinal peptide receptor 1 / P32241*ENSMUSG0000003252841
P70205 / Adcyap1r1 / adenylate cyclase activating polypeptide 1 receptor 1 / P41586* / ADCYAP receptor type I*ENSMUSG0000002977840
Sctr / Q5FWI2 / Secretin receptor / P47872*ENSMUSG0000002638738
Vipr2 / P41588 / vasoactive intestinal peptide receptor 2 / P41587*ENSMUSG0000001117136
Pth1r / P41593 / Parathyroid hormone/parathyroid hormone-related peptide receptor / Q03431* / parathyroid hormone 1 receptor*ENSMUSG0000003249234
Glp1r / O35659 / Glucagon-like peptide 1 receptor / P43220*ENSMUSG0000002402733
Gcgr / Q61606 / Glucagon receptor / P47871*ENSMUSG0000002512732
Pth2r / Q91V95 / Parathyroid hormone 2 receptor / P49190*ENSMUSG0000002594631
Gipr / Q0P543 / Gastric inhibitory polypeptide receptor / P48546*ENSMUSG0000003040630
Glp2r / Q5IXF8 / Glucagon-like peptide 2 receptor / O95838*ENSMUSG0000004992830


Protein motifs (from Interpro)
Interpro ID Name
 IPR000832  GPCR, family 2, secretin-like
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR003288  GPCR, family 2, growth hormone-releasing hormone receptor
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR036445  GPCR family 2, extracellular hormone receptor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007190 activation of adenylate cyclase activity IEA
 biological_processGO:0007595 lactation IMP
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008340 determination of adult lifespan IMP
 biological_processGO:0019933 cAMP-mediated signaling IEA
 biological_processGO:0021984 adenohypophysis development IMP
 biological_processGO:0030104 water homeostasis IGI
 biological_processGO:0030252 growth hormone secretion IMP
 biological_processGO:0030816 obsolete positive regulation of cAMP metabolic process IEA
 biological_processGO:0030879 mammary gland development IMP
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0032869 cellular response to insulin stimulus IDA
 biological_processGO:0033143 regulation of intracellular steroid hormone receptor signaling pathway IMP
 biological_processGO:0040018 positive regulation of multicellular organism growth IEA
 biological_processGO:0042445 hormone metabolic process IMP
 biological_processGO:0043567 regulation of insulin-like growth factor receptor signaling pathway IMP
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep IEA
 biological_processGO:0046887 positive regulation of hormone secretion IMP
 biological_processGO:0048469 cell maturation IMP
 biological_processGO:0051246 regulation of protein metabolic process IGI
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0060124 positive regulation of growth hormone secretion IEA
 biological_processGO:0060133 somatotropin secreting cell development IMP
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 cellular_componentGO:0005637 nuclear inner membrane IEA
 cellular_componentGO:0005640 nuclear outer membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0042383 sarcolemma IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016520 growth hormone-releasing hormone receptor activity IEA
 molecular_functionGO:0017046 peptide hormone binding IPI
 molecular_functionGO:0019838 growth factor binding IEA


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Glucagon-type ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Fgfr3tm2Schl/Fgfr3tm2Schl
Genetic Background: involves: 129S1/Sv * CD-1 * FVB/N

Allelic Composition: Ghrhrlit/Ghrhrlit,M14104Asr/M14104Asr+
Genetic Background: C57BL/6J-Ghrhrlit M14104Asr

Allelic Composition: Ghrhrlit/Ghrhrlit
Genetic Background: C57BL/6J-Ghrhrlit/J

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Ghrhrlit/Ghrhrlit
Genetic Background: C57BL/6J-Ghrhrlit/J

Allelic Composition: Ghrhrlit/Ghrhrlit,Prlrtm1Cnp/Prlrtm1Cnp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Plcl1tm2.1Matk/Plcl1tm2.1Matk
Genetic Background: FVB.Cg-Plcl1tm2.1Matk

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Fgfr3tm2Schl/Fgfr3tm2Schl
Genetic Background: involves: 129S1/Sv * CD-1 * FVB/N

Allelic Composition: Ghrhrlit/Ghrhrlit,M14104Asr/M14104Asr+
Genetic Background: C57BL/6J-Ghrhrlit M14104Asr

Allelic Composition: Ghrhrlit/Ghrhrlit
Genetic Background: C57BL/6J-Ghrhrlit/J

Allelic Composition: Ghrhrlit/Ghrhrlit,Prlrtm1Cnp/Prlrtm1Cnp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ghrhrlit/Ghrhrlit
Genetic Background: C3.B6-Ghrhrlit/J

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: KitlSl-d/Kitl+
Genetic Background: involves: DBA/2J

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001731 abnormal postnatal growth "anomaly in reaching a developmental stage or stages after birth" [il:Ira Lu, Mouse Genome Informatics Curator]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001882 abnormal lactation "atypical production of milk from the mammary gland" [J:51296]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grin2btm1Mim/Grin2btm1Mim
Genetic Background: involves: C57BL/6 * CBA

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ghrhrlit/Ghrhrlit
Genetic Background: C57BL/6J-Ghrhrlit/J

Allelic Composition: Ghrhrlit/Ghrhrlit,Prlrtm1Cnp/Prlrtm1Cnp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ghrhrlit/Ghrhrlit
Genetic Background: C57BL/6J-Ghrhrlit/J

Allelic Composition: Ghrhrlit/Ghrhrlit,Prlrtm1Cnp/Prlrtm1Cnp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ghrhrlit/Ghrhrlit
Genetic Background: C3.B6-Ghrhrlit/J

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0003194 abnormal frequency of paradoxical sleep "abnormal incidence or duration of the sleep stage in which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003212 susceptibility to age related obesity "increased probability of excessive weight gain that is progressive with age" [RGD:Rat Genome Database submission]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ghrhrlit/Ghrhrlit,Prlrtm1Cnp/Prlrtm1Cnp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003795 abnormal bone structure 
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Allelic Composition: Ghrhrlit/Ghrhrlit
Genetic Background: C57BL/6J-Ghrhrlit/J

Allelic Composition: Ghrhrlit/Ghrhrlit
Genetic Background: C3.B6-Ghrhrlit/J

Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Ghrhrlit/Ghrhrlit
Genetic Background: C57BL/6J-Ghrhrlit/J

Allelic Composition: Ghrhrlit/Ghrhrlit,Prlrtm1Cnp/Prlrtm1Cnp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ghrhrlit/Ghrhr+,M14104Asr/M14104Asr+
Genetic Background: C57BL/6J-Ghrhrlit M14104Asr

Allelic Composition: Ghrhrlit/Ghrhrlit,M14104Asr/M14104Asr+
Genetic Background: C57BL/6J-Ghrhrlit M14104Asr

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ghrhrlit/Ghrhrlit
Genetic Background: C57BL/6J-Ghrhrlit/J

Allelic Composition: Ghrhrlit/Ghrhrlit,Prlrtm1Cnp/Prlrtm1Cnp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005120 decreased circulating growth hormone level "less than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005136 decreased growth hormone level "less than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005138 decreased prolactin level "less than expected concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ghrhrlit/Ghrhrlit,Prlrtm1Cnp/Prlrtm1Cnp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ghrhrlit/Ghrhrlit,Prlrtm1Cnp/Prlrtm1Cnp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005361 small pituitary gland "reduced size of the pituitary gland, the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Ghrhrlit/Ghrhrlit,Prlrtm1Cnp/Prlrtm1Cnp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ghrhrlit/Ghrhrlit
Genetic Background: C57BL/6J-Ghrhrlit/J

Allelic Composition: Ghrhrlit/Ghrhrlit,Prlrtm1Cnp/Prlrtm1Cnp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0005642 decreased mean corpuscular hemoglobin concentration "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
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Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Ghrhrlit/Ghrhrlit,Prlrtm1Cnp/Prlrtm1Cnp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008152 decreased diameter of femur "reduced width of the cross-sectional distance that extends from one lateral edge of the femur, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ghrhrlit/Ghrhr+,M14104Asr/M14104Asr+
Genetic Background: C57BL/6J-Ghrhrlit M14104Asr

Allelic Composition: Ghrhrlit/Ghrhrlit,M14104Asr/M14104Asr+
Genetic Background: C57BL/6J-Ghrhrlit M14104Asr

 MP:0008162 increased diameter of tibia "increased width of the cross-sectional distance that extends from one lateral edge of the tibia, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ghrhrlit/Ghrhr+,M14104Asr/M14104Asr+
Genetic Background: C57BL/6J-Ghrhrlit M14104Asr

Allelic Composition: Ghrhrlit/Ghrhrlit,M14104Asr/M14104Asr+
Genetic Background: C57BL/6J-Ghrhrlit M14104Asr

 MP:0008322 abnormal somatotroph morphology "any structural anomaly of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin" [CL:0000295, MESH:A06.407.747.608.937]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008329 decreased somatotroph cell number "reduced number of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin" [CL:0000295, MESH:A06.407.747.608.937]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008417 decreased somatotroph cell size "reduced growth or small size of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin" [MESH:A06.407.747.608.937, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008436 decreased somatotroph secretory granule number "decreased number of vesicles derived from the golgi that contain somatotropin growth hormone to be released at the cell surface" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008437 absent somatoptroph secretory granules "absence of vesicles derived from the golgi that contain somatotropin growth hormone to be released at the cell surface" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ghrhrlit/Ghrhrlit
Genetic Background: C57BL/6J-Ghrhrlit/J

Allelic Composition: Ghrhrlit/Ghrhrlit,Prlrtm1Cnp/Prlrtm1Cnp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008831 abnormal insulin-like growth factor I level "aomaly in the concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MESH:D12.644.276.937.400, MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Ghrhrlit/Ghrhrlit
Genetic Background: C57BL/6J-Ghrhrlit/J

Allelic Composition: Ghrhrlit/Ghrhrlit
Genetic Background: C3.B6-Ghrhrlit/J

 MP:0008974 proportional dwarf "abnormally undersized with both limbs and trunk symmetrically shorter; usually due to chemical, endocrine, nutritional or nonosseous influences" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ghrhrlit/Ghrhrlit
Genetic Background: C57BL/6J-Ghrhrlit/J

Allelic Composition: Ghrhrlit/Ghrhrlit,Prlrtm1Cnp/Prlrtm1Cnp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0010119 abnormal bone mineral density "anomaly in the amount of mineral per square centimeter of bone (usually g/cm2), used as a measure of structural strength and screen for osteoporosis; bone mineral density is the ratio of bone mineral content to bone size" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ghrhrlit/Ghrhrlit
Genetic Background: C3.B6-Ghrhrlit/J

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0010511 shortened PR interval "decrease in the length of time between the beginning of atrial depolarization and the beginning of ventricular depolarization, measured by the interval from the beginning of the P wave to the beginning of the QRS complex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0011275 abnormal behavioral response to light "unexpected change in the activity of an organism (in terms of movement, outward responses) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light" [GO:0009416, MGI:llw2]
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Allelic Composition: Foxo3tm1.1(KOMP)Vlcg/Foxo3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Foxo3tm1.1(KOMP)Vlcg/J

 MP:0011396 abnormal sleep behavior "any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]
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Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0011954 shortened PQ interval "decrease in the length of time between the beginning of atrial depolarization and the end of atrial repolarization (or recovery), measured by the interval from the beginning of the P wave to the end of the Q wave" [MPD:Molly]
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Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0013616 decreased volumetric bone mineral density "reduction in the mineral mass per unit volume of bone, the hard, rigid form of connective tissue constituting most of the skeleton of vertebrates and composed chiefly of calcium salts; this is expressed as the amount of mineral per cubic cm of bone (usually in mgHA/cm^3), with results generated from Quantitative computed tomography (QCT) and other tests" [PMID:12730800, PMID:17481978]
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Allelic Composition: Ghrhrlit/Ghrhrlit
Genetic Background: C3.B6-Ghrhrlit/J

 MP:0020010 decreased bone mineral density of femur "reduction in the amount of mineral per square centimeter of bone (usually g/cm2) in the long bone of the thigh" [GOC:NV]
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Allelic Composition: Ghrhrlit/Ghrhrlit
Genetic Background: C3.B6-Ghrhrlit/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027643 Ghrh / P16043 / Mus musculus growth hormone releasing hormone (Ghrh), transcript variant 2, mRNA. / P01286* / growth hormone releasing hormone*  / complex / reaction






 

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