ENSMUSG00000004947


Mus musculus
zincDtx2fingerwwedomainbindingring-typenotchproteinnucleusionringfyvephd-typesubgroupchcsuperfamilysignalingpathwayubiquitinationnucleoplasmcytoplasmnuclearmembranetransferaseactivitymetalactivatedtransmitssignal

Features
Gene ID: ENSMUSG00000004947
  
Biological name :Dtx2
  
Synonyms : Dtx2 / Probable E3 ubiquitin-protein ligase DTX2 / Q8R3P2
  
Possible biological names infered from orthology : deltex E3 ubiquitin ligase 2 / Q86UW9
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: G2
Gene start: 135994800
Gene end: 136032872
  
Corresponding Affymetrix probe sets: 10526427 (MoGene1.0st)   1421720_a_at (Mouse Genome 430 2.0 Array)   1439429_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115122
Ensembl peptide - ENSMUSP00000106775
Ensembl peptide - ENSMUSP00000119285
Ensembl peptide - ENSMUSP00000142472
Ensembl peptide - ENSMUSP00000005072
Ensembl peptide - ENSMUSP00000106772
Ensembl peptide - ENSMUSP00000106774
NCBI entrez gene - 74198     See in Manteia.
MGI - MGI:1921448
RefSeq - XM_017321120
RefSeq - NM_001256096
RefSeq - NM_001256097
RefSeq - NM_001256098
RefSeq - NM_023742
RefSeq - XM_006504506
RefSeq - XM_006504507
RefSeq - XM_006504508
RefSeq - XM_006504510
RefSeq Peptide - NP_001243027
RefSeq Peptide - NP_076231
RefSeq Peptide - NP_001243025
RefSeq Peptide - NP_001243026
swissprot - Q8R3P2
swissprot - A0A0R4IZY1
swissprot - A0A1C7ZMZ6
swissprot - A0A0G2JDR7
Ensembl - ENSMUSG00000004947
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dtx2ENSDARG00000032933Danio rerio
 DTX2ENSGALG00000001905Gallus gallus
 DTX2ENSG00000091073Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dtx1 / Q61010 / E3 ubiquitin-protein ligase DTX1 / Q86Y01* / deltex E3 ubiquitin ligase 1*ENSMUSG0000002960346
Dtx4 / Q6PDK8 / E3 ubiquitin-protein ligase DTX4 / Q9Y2E6* / deltex E3 ubiquitin ligase 4*ENSMUSG0000003998244
Dtx3l / Q3UIR3 / E3 ubiquitin-protein ligase DTX3L / Q8TDB6* / deltex E3 ubiquitin ligase 3L*ENSMUSG0000004950222
Dtx3 / Q80V91 / Probable E3 ubiquitin-protein ligase DTX3 / Q8N9I9* / deltex E3 ubiquitin ligase 3*ENSMUSG0000004041516


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR004170  WWE domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR018123  WWE domain, subgroup
 IPR018957  Zinc finger, C3HC4 RING-type
 IPR037197  WWE domain superfamily


Gene Ontology (GO)
cell communicationcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcell communicationcellular response to stcellular response to stimulusnitrogen compound metabnitrogen compound metabolic processcellular metabolic proccellular metabolic processprimary metabolic proceprimary metabolic processorganic substance metaborganic substance metabolic process
protein bindingion bindingtransferase activityprotein bindingion bindingtransferase activityprotein bindingion bindingtransferase activityprotein bindingion bindingtransferase activityprotein bindingion bindingtransferase activityprotein bindingion bindingtransferase activityprotein bindingion bindingtransferase activityprotein bindingion bindingtransferase activityprotein bindingion bindingtransferase activityprotein bindingion bindingtransferase activityprotein bindingprotein bindingion bindingion bindingtransferase activitytransferase activity
cellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenmembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0007219 Notch signaling pathway TAS
 biological_processGO:0016567 protein ubiquitination IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0031965 nuclear membrane ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Activated NOTCH1 Transmits Signal to the Nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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