ENSMUSG00000005891


Mus musculus

Features
Gene ID: ENSMUSG00000005891
  
Biological name :Prl4a1
  
Synonyms : O35256 / Prl4a1 / prolactin family 4, subfamily a, member 1
  
Possible biological names infered from orthology : P01236 / PRL / prolactin
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A3.1
Gene start: 28016212
Gene end: 28023559
  
Corresponding Affymetrix probe sets: 10404341 (MoGene1.0st)   1448572_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021779
NCBI entrez gene - 19110     See in Manteia.
MGI - MGI:1206587
RefSeq - NM_011165
RefSeq Peptide - NP_035295
swissprot - A0A0M6L0M4
swissprot - O35256
Ensembl - ENSMUSG00000005891
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prlENSDARG00000037946Danio rerio
 prlENSGALG00000012671Gallus gallus
 PRLENSG00000172179Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prl2c1 / Prolactin family 2, subfamily c, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000006255136
Prl7b1 / Q8CGZ9 / Prolactin-7B1 / PRL* / P01236* / prolactin*ENSMUSG0000002134735
Prl2a1 / Q9JHK0 / prolactin family 2, subfamily a, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000002288635
Prl7c1 / Q9CRB5 / prolactin family 7, subfamily c, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000006073835
Prl3a1 / prolactin family 3, subfamily a, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000003888334
Prl3d3 / prolactin family 3, subfamily d, member 3 / PRL* / P01236* / prolactin*ENSMUSG0000006220134
Prl2b1 / Q9DAZ2 / prolactin family 2, subfamily b, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000006925834
Prl / P06879 / prolactin / P01236*ENSMUSG0000002134233
Prl2c5 / Q9JLV9 / Prolactin-2C5 / PRL* / P01236* / prolactin*ENSMUSG0000005536033
Prl3d1 / prolactin family 3, subfamily d, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000005717033
Prl3d2 / prolactin family 3, subfamily d, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000006273733
Prl2c2 / P04095 / Prolactin-2C2 / PRL* / P01236* / prolactin*ENSMUSG0000007909232
Prl7d1 / P04769 / prolactin family 7, subfamily d, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000002134831
P04768 / Prl2c3 / Mus musculus prolactin family 2, subfamily c, member 4 (Prl2c4), mRNA. / PRL* / P01236* / prolactin*ENSMUSG0000005645731
Prl6a1 / O35257 / prolactin family 6, subfamily a, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000006925931
Prl5a1 / Q9JII2 / prolactin family 5, subfamily a, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000001706429
Prl3b1 / P09586 / prolactin family 3, subfamily b, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000003889129
Prl3c1 / Q9QUN5 / prolactin family 3, subfamily c, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000001792224


Protein motifs (from Interpro)
Interpro ID Name
 IPR001400  Somatotropin/prolactin
 IPR009079  Four-helical cytokine-like, core
 IPR018116  Somatotropin hormone, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0005148 prolactin receptor binding ISS
 molecular_functionGO:0005179 hormone activity IEA


Pathways (from Reactome)
Pathway description
Prolactin receptor signaling
Growth hormone receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0001711 abnormal placenta 
Show

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0005032 abnormal ectoplacental cone 
Show

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0005033 abnormal trophoblast cells "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp
Genetic Background: involves: 129S2/SvPas * CF1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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