ENSMUSG00000006021


Mus musculus

Features
Gene ID: ENSMUSG00000006021
  
Biological name :Kptn
  
Synonyms : kaptin, actin binding protein / Kptn
  
Possible biological names infered from orthology : Q9Y664
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A2
Gene start: 16119895
Gene end: 16127516
  
Corresponding Affymetrix probe sets: 10550250 (MoGene1.0st)   1423438_at (Mouse Genome 430 2.0 Array)   1440025_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006178
NCBI entrez gene - 70394     See in Manteia.
MGI - MGI:1890380
RefSeq - NM_133727
RefSeq Peptide - NP_598488
swissprot - G3X8R1
Ensembl - ENSMUSG00000006021
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kptnENSDARG00000015937Danio rerio
 KPTNENSG00000118162Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR029982  Kaptin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0034198 cellular response to amino acid starvation IEA
 biological_processGO:0042149 cellular response to glucose starvation IEA
 biological_processGO:0061462 protein localization to lysosome IEA
 biological_processGO:1904262 negative regulation of TORC1 signaling IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0031941 filamentous actin IEA
 cellular_componentGO:0098871 postsynaptic actin cytoskeleton IEA
 cellular_componentGO:0140007 KICSTOR complex IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kptntm1a(EUCOMM)Wtsi/Kptntm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Kptntm1a(EUCOMM)Wtsi/Wtsi

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Kptntm1a(EUCOMM)Wtsi/Kptntm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Kptntm1a(EUCOMM)Wtsi/Wtsi

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0002965 hyperalbuminemia "blood albumin concentration above the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Kptntm1a(EUCOMM)Wtsi/Kptntm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Kptntm1a(EUCOMM)Wtsi/Wtsi

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Kptntm1a(EUCOMM)Wtsi/Kptntm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Kptntm1a(EUCOMM)Wtsi/Wtsi

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kptntm1a(EUCOMM)Wtsi/Kptntm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Kptntm1a(EUCOMM)Wtsi/Wtsi

 MP:0005568 increased circulating total protein level "greater than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
Show

Allelic Composition: Kptntm1a(EUCOMM)Wtsi/Kptntm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Kptntm1a(EUCOMM)Wtsi/Wtsi

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kptntm1a(EUCOMM)Wtsi/Kptntm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Kptntm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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