ENSMUSG00000006221


Mus musculus

Features
Gene ID: ENSMUSG00000006221
  
Biological name :Hspb7
  
Synonyms : Heat shock protein beta-7 / Hspb7 / P35385
  
Possible biological names infered from orthology : heat shock protein family B (small) member 7 / Q9UBY9
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D3
Gene start: 141420779
Gene end: 141425311
  
Corresponding Affymetrix probe sets: 10509992 (MoGene1.0st)   1421289_at (Mouse Genome 430 2.0 Array)   1421290_at (Mouse Genome 430 2.0 Array)   1434927_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099544
NCBI entrez gene - 29818     See in Manteia.
MGI - MGI:1352494
RefSeq - NM_013868
RefSeq Peptide - NP_038896
swissprot - P35385
Ensembl - ENSMUSG00000006221
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hspb7ENSDARG00000104441Danio rerio
 HSPB7ENSGALG00000023772Gallus gallus
 HSPB7ENSG00000173641Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001436  Alpha crystallin/Heat shock protein
 IPR002068  Alpha crystallin/Hsp20 domain
 IPR008978  HSP20-like chaperone
 IPR031107  Small heat shock protein HSP20


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007507 heart development IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0015030 Cajal body IEA
 cellular_componentGO:0015629 actin cytoskeleton IPI
 cellular_componentGO:0016235 aggresome IEA
 molecular_functionGO:0031005 filamin binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hspb7tm1.1Chen/Hspb7tm1.1Chen,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0000277 abnormal heart shape "malformation of the form or the patterning of the heart" [J:18048]
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Allelic Composition: Tmem59tm1.1Tqw/Tmem59tm1.1Tqw,Tg(Thy1-EGFP)MJrs/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Tmem59tm1.1Tqw/Tmem59tm1.1Tqw,Tg(Thy1-EGFP)MJrs/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA

 MP:0000751 myopathy "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574]
Show

Allelic Composition: Apelatm1.2Brre/Apela+
Genetic Background: B6(Cg)-Apelatm1.2Brre

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Apelatm1.2Brre/Apela+
Genetic Background: B6(Cg)-Apelatm1.2Brre

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apelatm1.2Brre/Apela+
Genetic Background: B6(Cg)-Apelatm1.2Brre

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
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Allelic Composition: Tmem59tm1.1Tqw/Tmem59tm1.1Tqw,Tg(Thy1-EGFP)MJrs/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA

 MP:0002279 abnormal diaphragm morphology "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apelatm1.2Brre/Apela+
Genetic Background: B6(Cg)-Apelatm1.2Brre

 MP:0002297 abnormal forced expiratory flow rates "anomaly in the rates of airflow during forced vital capacity determination" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apelatm1.2Brre/Apela+
Genetic Background: B6(Cg)-Apelatm1.2Brre

 MP:0002327 abnormal respiratory function "anomaly in any measure of the processes involved in respiration" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apelatm1.2Brre/Apela+
Genetic Background: B6(Cg)-Apelatm1.2Brre

 MP:0004067 abnormal ventricular trabeculae morphology "aberrant structure of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Tmem59tm1.1Tqw/Tmem59tm1.1Tqw,Tg(Thy1-EGFP)MJrs/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Apelatm1.2Brre/Apela+
Genetic Background: B6(Cg)-Apelatm1.2Brre

Allelic Composition: Hspb7tm1.2Chen/Hspb7tm1.2Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Hspb7tm1.2Chen/Hspb7tm1.2Chen,Lmod2tm1(KOMP)Vlcg/Lmod2tm1(KOMP)Vlcg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac * CBA

Allelic Composition: Hspb7tm1.2Chen/Hspb7tm1.2Chen,Tg(Myh6-Tmod1)65Msus/Tg(Myh6-Tmod1)65Msus
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB/N

 MP:0004091 abnormal Z lines "any structural abnormality in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Apelatm1.2Brre/Apela+
Genetic Background: B6(Cg)-Apelatm1.2Brre

Allelic Composition: Hspb7tm1.2Chen/Hspb7tm1.2Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004783 abnormal cardinal vein morphology "any structural anomaly of any of the four veins in the developing vertebrate embryo which run along each side of the vertebral column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hspb7tm1.2Chen/Hspb7tm1.2Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tmem59tm1.1Tqw/Tmem59tm1.1Tqw,Tg(Thy1-EGFP)MJrs/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA

 MP:0008788 abnormal fetal cardiomyocyte morphology "any structural anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [PMID:17429040]
Show

Allelic Composition: Hspb7tm1.2Chen/Hspb7tm1.2Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Hspb7tm1.2Chen/Hspb7tm1.2Chen,Lmod2tm1(KOMP)Vlcg/Lmod2tm1(KOMP)Vlcg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac * CBA

Allelic Composition: Hspb7tm1.2Chen/Hspb7tm1.2Chen,Tg(Myh6-Tmod1)65Msus/Tg(Myh6-Tmod1)65Msus
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB/N

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apelatm1.2Brre/Apela+
Genetic Background: B6(Cg)-Apelatm1.2Brre

 MP:0009419 skeletal muscle fibrosis "formation of fibrous tissue within skeletal muscle as a result of repair or a reactive process" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Apelatm1.2Brre/Apela+
Genetic Background: B6(Cg)-Apelatm1.2Brre

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Apelatm1.2Brre/Apela+
Genetic Background: B6(Cg)-Apelatm1.2Brre

 MP:0010090 increased circulating creatine kinase level "an elevation in the concentration in the blood of an enzyme that catalyzes the reversible transfer of creatine to phosphocreatine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apelatm1.2Brre/Apela+
Genetic Background: B6(Cg)-Apelatm1.2Brre

 MP:0010580 decreased heart left ventricle size "less than average size of the left ventricle compared to the average for a particular population" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hspb7tm1.2Chen/Hspb7tm1.2Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Apelatm1.2Brre/Apela+
Genetic Background: B6(Cg)-Apelatm1.2Brre

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Hspb7tm1.2Chen/Hspb7tm1.2Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Hspb7tm1.1Chen/Hspb7tm1.1Chen,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

Allelic Composition: Hspb7tm1.1Chen/Hspb7tm1.1Chen,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Hspb7tm1.2Chen/Hspb7tm1.2Chen,Lmod2tm1(KOMP)Vlcg/Lmod2tm1(KOMP)Vlcg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac * CBA

 MP:0011395 decreased fetal cardiomyocyte proliferation "reduced ability of the differentiating cardiac muscle cell population to undergo expansion by cell division" [MGI:csmith]
Show

Allelic Composition: Hspb7tm1.2Chen/Hspb7tm1.2Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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