ENSMUSG00000006281


Mus musculus
bindingTep1domainwdsuperfamilyrnatelomeraserepeatnucleosidetrove-repeat-containingchromosomespliceosomeincreasednachttriphosphatasetepn-terminalyvtnrepeat-like-containingconservedsiteunknownfunctiondufp-loopcontainingtriphosphatehydrolasetelomeremaintenance

Features
Gene ID: ENSMUSG00000006281
  
Biological name :Tep1
  
Synonyms : P97499 / Telomerase protein component 1 / Tep1
  
Possible biological names infered from orthology : Q99973 / telomerase associated protein 1
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C1
Gene start: 50824059
Gene end: 50870560
  
Corresponding Affymetrix probe sets: 10419471 (MoGene1.0st)   1418196_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006444
Ensembl peptide - ENSMUSP00000153878
Ensembl peptide - ENSMUSP00000154492
Ensembl peptide - ENSMUSP00000154505
NCBI entrez gene - 21745     See in Manteia.
MGI - MGI:109573
RefSeq - NM_009351
RefSeq - XM_006518797
RefSeq Peptide - NP_033377
swissprot - P97499
Ensembl - ENSMUSG00000006281
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tep1ENSDARG00000038713Danio rerio
 TEP1ENSG00000129566Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rrp9 / Q91WM3 / U3 small nucleolar RNA-interacting protein 2 / O43818* / ribosomal RNA processing 9, U3 small nucleolar RNA binding protein*ENSMUSG000000415064


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR007111  NACHT nucleoside triphosphatase
 IPR008850  TEP1, N-terminal
 IPR008858  TROVE domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR025139  Domain of unknown function DUF4062
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036322  WD40-repeat-containing domain superfamily
 IPR037214  TROVE domain superfamily


Gene Ontology (GO)
nitrogen compound metabolic processcellular component organizationcellular metabolic processprimary metabolic processregulation of biological qualityorganic substance metabolic processbiosynthetic processnitrogen compound metabolic processcellular component organizationcellular metabolic processprimary metabolic processregulation of biological qualityorganic substance metabolic processbiosynthetic processnitrogen compound metabolic processcellular component organizationcellular metabolic processprimary metabolic processregulation of biological qualityorganic substance metabolic processbiosynthetic processnitrogen compound metabolic processcellular component organizationcellular metabolic processprimary metabolic processregulation of biological qualityorganic substance metabolic processbiosynthetic processnitrogen compound metabolic processcellular component organizationcellular metabolic processprimary metabolic processregulation of biological qualityorganic substance metabolic processbiosynthetic processnitrogen compound metabolic processcellular component organizationcellular metabolic processprimary metabolic processregulation of biological qualityorganic substance metabolic processbiosynthetic processnitrogen compound metabolic processcellular component organizationcellular metabolic processprimary metabolic processregulation of biological qualityorganic substance metabolic processbiosynthetic processnitrogen compound metabolic processcellular component organizationcellular metabolic processprimary metabolic processregulation of biological qualityorganic substance metabolic processbiosynthetic processnitrogen compound metabolic processcellular component organizationcellular metabolic processprimary metabolic processregulation of biological qualityorganic substance metabolic processbiosynthetic processnitrogen compound metabolic processcellular component organizationcellular metabolic processprimary metabolic processregulation of biological qualityorganic substance metabolic processbiosynthetic processnitrogen compound menitrogen compound metabolic processcellular component ocellular component organizationcellular metabolic pcellular metabolic processprimary metabolic prprimary metabolic processregulation of biologregulation of biological qualityorganic substance meorganic substance metabolic processbiosynthetic processbiosynthetic process
organic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingprotein bindingcatalytic activity, acting on DNAtransferase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingprotein bindingcatalytic activity, acting on DNAtransferase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingprotein bindingcatalytic activity, acting on DNAtransferase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingprotein bindingcatalytic activity, acting on DNAtransferase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingprotein bindingcatalytic activity, acting on DNAtransferase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingprotein bindingcatalytic activity, acting on DNAtransferase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingprotein bindingcatalytic activity, acting on DNAtransferase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingprotein bindingcatalytic activity, acting on DNAtransferase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingprotein bindingcatalytic activity, acting on DNAtransferase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingprotein bindingcatalytic activity, acting on DNAtransferase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic organic cyclic compound bindingheterocyclic coheterocyclic compound bindingsmall molecule small molecule bindingprotein bindingprotein bindingcatalytic activcatalytic activity, acting on DNAtransferase acttransferase activityion bindingion bindingcarbohydrate decarbohydrate derivative bindingdrug bindingdrug binding
cellorganelleprotein-containing complexmembrane-enclosed lumencellorganelleprotein-containing complexmembrane-enclosed lumencellorganelleprotein-containing complexmembrane-enclosed lumencellorganelleprotein-containing complexmembrane-enclosed lumencellorganelleprotein-containing complexmembrane-enclosed lumencellorganelleprotein-containing complexmembrane-enclosed lumencellorganelleprotein-containing complexmembrane-enclosed lumencellorganelleprotein-containing complexmembrane-enclosed lumencellorganelleprotein-containing complexmembrane-enclosed lumencellorganelleprotein-containing complexmembrane-enclosed lumencellcellorganelleorganelleprotein-containing complexprotein-containing complexmembrane-enclosed lumenmembrane-enclosed lumen
TypeGO IDTermEv.Code
 biological_processGO:0000722 telomere maintenance via recombination IEA
 biological_processGO:0006278 RNA-dependent DNA biosynthetic process IEA
 biological_processGO:0008380 RNA splicing IBA
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005682 U5 snRNP IBA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005697 telomerase holoenzyme complex IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0071011 precatalytic spliceosome IBA
 cellular_componentGO:0071013 catalytic step 2 spliceosome IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0003720 telomerase activity IEA
 molecular_functionGO:0003723 RNA binding IMP
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0070034 telomerase RNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
growth/size phenotypehomeostasis/metabolism phenotypeskeleton phenotypegrowth/size phenotypehomeostasis/metabolism phenotypeskeleton phenotypegrowth/size phenotypehomeostasis/metabolism phenotypeskeleton phenotypegrowth/size phenotypehomeostasis/metabolism phenotypeskeleton phenotypegrowth/size phenotypehomeostasis/metabolism phenotypeskeleton phenotypegrowth/size phenotypehomeostasis/metabolism phenotypeskeleton phenotypegrowth/size phenotypehomeostasis/metabolism phenotypeskeleton phenotypegrowth/size phenotypehomeostasis/metabolism phenotypeskeleton phenotypegrowth/size phenotypehomeostasis/metabolism phenotypeskeleton phenotypegrowth/size phenotypehomeostasis/metabolism phenotypeskeleton phenotypegrowth/size phenotypegrowth/size phenotypehomeostasis/metabolism phenotypehomeostasis/metabolism phenotypeskeleton phenotypeskeleton phenotype
IDPhenotypeDefinition Genetic BG
 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Parp4tm1Leah/Parp4tm1Leah,Tep1tm1Leah/Tep1tm1Leah
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005627 increased circulating potassium level "greater than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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