ENSMUSG00000006522


Mus musculus
activityItih3inhibitorvonwillebrandfactordomainregulationpeptidaseendopeptidasetypeinter-alpha-trypsinheavychainc-terminalvita-likesuperfamilyhyaluronanmetabolicprocessextracellularregionserine-typeplateletdegranulation

Features
Gene ID: ENSMUSG00000006522
  
Biological name :Itih3
  
Synonyms : Inter-alpha-trypsin inhibitor heavy chain H3 / Itih3 / Q61704
  
Possible biological names infered from orthology : inter-alpha-trypsin inhibitor heavy chain 3 / Q06033
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: B
Gene start: 30908572
Gene end: 30923760
  
Corresponding Affymetrix probe sets: 10418434 (MoGene1.0st)   1449123_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006697
Ensembl peptide - ENSMUSP00000154256
Ensembl peptide - ENSMUSP00000154659
Ensembl peptide - ENSMUSP00000154720
NCBI entrez gene - 16426     See in Manteia.
MGI - MGI:96620
RefSeq - XM_006518588
RefSeq - NM_008407
RefSeq - XM_006518586
RefSeq - XM_006518587
RefSeq - XM_006518585
RefSeq Peptide - NP_032433
swissprot - Q61704
Ensembl - ENSMUSG00000006522
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itih1ENSDARG00000055053Danio rerio
 itih3aENSDARG00000055036Danio rerio
 ENSGALG00000001697Gallus gallus
 ITIH3ENSG00000162267Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Itih1 / Q61702 / Inter-alpha-trypsin inhibitor heavy chain H1 / P19827* / inter-alpha-trypsin inhibitor heavy chain 1*ENSMUSG0000000652953
Itih4 / A6X935 / Inter alpha-trypsin inhibitor, heavy chain 4 / Q14624* / inter-alpha-trypsin inhibitor heavy chain family member 4*ENSMUSG0000002192242
Itih2 / inter-alpha trypsin inhibitor, heavy chain 2 / P19823*ENSMUSG0000003725440
Itih5 / Q8BJD1 / Inter-alpha-trypsin inhibitor heavy chain H5 / inter-alpha-trypsin inhibitor heavy chain family member 5*ENSMUSG0000002578033


Protein motifs (from Interpro)
Interpro ID Name
 IPR002035  von Willebrand factor, type A
 IPR010600  Inter-alpha-trypsin inhibitor heavy chain, C-terminal
 IPR013694  VIT domain
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
nitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processsmall molecule metabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processsmall molecule metabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processsmall molecule metabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processsmall molecule metabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processsmall molecule metabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processsmall molecule metabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processsmall molecule metabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processsmall molecule metabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processsmall molecule metabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processsmall molecule metabolic processnitrogen compound metabnitrogen compound metabolic processcellular metabolic proccellular metabolic processprimary metabolic proceprimary metabolic processregulation of molecularregulation of molecular functionorganic substance metaborganic substance metabolic processsmall molecule metabolismall molecule metabolic process
enzyme regulator activityenzyme regulator activityenzyme regulator activityenzyme regulator activityenzyme regulator activityenzyme regulator activityenzyme regulator activityenzyme regulator activityenzyme regulator activityenzyme regulator activityenzyme regulator activityenzyme regulator activity
extracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0030212 hyaluronan metabolic process IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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