ENSMUSG00000006931


Mus musculus

Features
Gene ID: ENSMUSG00000006931
  
Biological name :P3h4
  
Synonyms : Endoplasmic reticulum protein SC65 / P3h4 / Q8K2B0
  
Possible biological names infered from orthology : prolyl 3-hydroxylase family member 4 (non-enzymatic) / Q92791
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 100408456
Gene end: 100414836
  
Corresponding Affymetrix probe sets: 10391119 (MoGene1.0st)   1455288_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000065278
Ensembl peptide - ENSMUSP00000135217
NCBI entrez gene - 66180     See in Manteia.
MGI - MGI:1913430
RefSeq - NM_176830
RefSeq Peptide - NP_789800
swissprot - H3BK18
swissprot - Q8K2B0
Ensembl - ENSMUSG00000006931
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 p3h4ENSDARG00000104089Danio rerio
 P3H4ENSGALG00000027462Gallus gallus
 P3H4ENSG00000141696Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Crtap / Q9CYD3 / Cartilage-associated protein / O75718*ENSMUSG0000003243148
P3h1 / Q3V1T4 / Prolyl 3-hydroxylase 1 / Q32P28*ENSMUSG0000002864131
P3h2 / Q8CG71 / Prolyl 3-hydroxylase 2 / Q8IVL5*ENSMUSG0000003816828
P3h3 / Q8CG70 / Prolyl 3-hydroxylase 3 / Q8IVL6*ENSMUSG0000002319125


Protein motifs (from Interpro)
Interpro ID Name
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR033213  Endoplasmic reticulum protein SC65


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0017185 peptidyl-lysine hydroxylation IMP
 biological_processGO:0030199 collagen fibril organization IMP
 biological_processGO:0032964 collagen biosynthetic process IMP
 biological_processGO:0046849 bone remodeling IMP
 cellular_componentGO:0000795 synaptonemal complex IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:1902494 catalytic complex IMP
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
Show

Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N

 MP:0003089 reduced skin tensile strength "reduction in the normal maximum tension the skin can withstand without tearing" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:48068]
Show

Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N

 MP:0008438 abnormal cutaneous collagen fibril morphology "any structural anomaly of the connective tissue bundles in the extracellular matrix of skin tissue that are composed of collagen, and play a role in skin strength and elasticity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N

 MP:0010933 decreased trabecular bone connectivity density "reduction in the extent of attachments between trabeculae; it may be expressed in ratios of nodes to free ends, trabecular bone pattern factor, and related measures" [ISBN:0120986523 "Principles of bone biology, Volume 1, Bilezikian, JP et al, eds"]
Show

Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N

 MP:0011642 abnormal bone collagen fibril morphology "any structural anomaly of the connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity" [MGI:csmith]
Show

Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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