ENSMUSG00000007589


Mus musculus

Features
Gene ID: ENSMUSG00000007589
  
Biological name :Tinf2
  
Synonyms : Terf1 (TRF1)-interacting nuclear factor 2 / Tinf2
  
Possible biological names infered from orthology : Q9BSI4 / TERF1 interacting nuclear factor 2
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C3
Gene start: 55674689
Gene end: 55681820
  
Corresponding Affymetrix probe sets: 10420097 (MoGene1.0st)   1437166_at (Mouse Genome 430 2.0 Array)   1451163_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000154730
Ensembl peptide - ENSMUSP00000007733
Ensembl peptide - ENSMUSP00000153900
Ensembl peptide - ENSMUSP00000154611
Ensembl peptide - ENSMUSP00000154628
NCBI entrez gene - 28113     See in Manteia.
MGI - MGI:107246
RefSeq - NM_145705
RefSeq - XM_006519080
RefSeq Peptide - NP_663751
swissprot - Q8K1K3
Ensembl - ENSMUSG00000007589
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TINF2ENSG00000092330Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR029400  TERF1-interacting nuclear factor 2, N-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010836 negative regulation of protein ADP-ribosylation IEA
 biological_processGO:0016233 telomere capping IEA
 biological_processGO:0032202 telomere assembly IEA
 biological_processGO:0032211 negative regulation of telomere maintenance via telomerase IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0070198 protein localization to chromosome, telomeric region IEA
 biological_processGO:1904356 regulation of telomere maintenance via telomere lengthening IEA
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0000783 nuclear telomere cap complex IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IEA
 cellular_componentGO:0010370 perinucleolar chromocenter IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0070187 shelterin complex IEA
 molecular_functionGO:0042162 telomeric DNA binding IEA


Pathways (from Reactome)
Pathway description
Packaging Of Telomere Ends
DNA Damage/Telomere Stress Induced Senescence


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000688 lymphoid hyperplasia "increased cell number in lymphatic tissues" [J:62478]
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Allelic Composition: Rock1tm1.2Itl/Rock1tm1.2Itl
Genetic Background: Not Specified

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Rock1tm1.2Itl/Rock1tm1.2Itl
Genetic Background: Not Specified

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Rock1tm1.2Itl/Rock1tm1.2Itl
Genetic Background: Not Specified

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Elntm1Dyl/Eln+,Mgptm1Kry/Mgptm1Kry
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Rock1tm1.2Itl/Rock1tm1.2Itl
Genetic Background: Not Specified

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Rock1tm1.2Itl/Rock1tm1.2Itl
Genetic Background: Not Specified

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rock1tm1.2Itl/Rock1tm1.2Itl
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Elntm1Dyl/Eln+,Mgptm1Kry/Mgptm1Kry
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rock1tm1.2Itl/Rock1tm1.2Itl
Genetic Background: Not Specified

 MP:0003155 abnormal telomere length "abnormal length of the terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability; normal length is a few hundred base pairs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Rock1tm1.2Itl/Rock1tm1.2Itl
Genetic Background: Not Specified

Allelic Composition: Terctm1Rdp/Terctm1Rdp,Tinf2tm2.2Tdl/Tinf2+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * SJL

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Rock1tm1.2Itl/Rock1tm1.2Itl
Genetic Background: Not Specified

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Terctm1Rdp/Terctm1Rdp,Tinf2tm2.2Tdl/Tinf2+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * SJL

 MP:0005152 pancytopenia "reduction in the number of erythrocytes, all types of white blood cells, and platelets in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:20450]
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Allelic Composition: Rock1tm1.2Itl/Rock1tm1.2Itl
Genetic Background: Not Specified

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Elntm1Dyl/Eln+,Mgptm1Kry/Mgptm1Kry
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rock1tm1.2Itl/Rock1tm1.2Itl
Genetic Background: Not Specified

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Rock1tm1.2Itl/Rock1tm1.2Itl
Genetic Background: Not Specified

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Plscr1tm1Lex/Plscr1tm1Lex,Plscr3tm1Sims/Plscr3tm1Sims
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Elntm1Dyl/Eln+,Mgptm1Kry/Mgptm1Kry
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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