Manteia - Molecule gene

ENSMUSG00000007805

Mus musculus

Features

Gene ID:	ENSMUSG00000007805

Biological name :	Twist2

Synonyms :	Twist2 / twist basic helix-loop-helix transcription factor 2

Possible biological names infered from orthology :	Q8WVJ9 / twist family bHLH transcription factor 2

Species:	Mus musculus

Chr. number:	1
Strand:	1
Band:	D
Gene start:	91801461
Gene end:	91848028

Corresponding Affymetrix probe sets:	10348632 (MoGene1.0st) 1448925_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000139531 Ensembl peptide - ENSMUSP00000007949 NCBI entrez gene - 13345 See in Manteia. MGI - MGI:104685 RefSeq - NM_007855 RefSeq Peptide - NP_031881 swissprot - A5D6P6 Ensembl - ENSMUSG00000007805

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
twist1a	ENSDARG00000030402	Danio rerio
twist1b	ENSDARG00000076010	Danio rerio
twist2	ENSDARG00000078266	Danio rerio
Q8WVJ9	ENSG00000233608	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
P26687 / Twist1 / twist basic helix-loop-helix transcription factor 1 / Q15672* / twist family bHLH transcription factor 1*	ENSMUSG00000035799	82
Tcf15 / Q60756 / Transcription factor 15 / Q12870*	ENSMUSG00000068079	30
Tal1 / P22091 / T cell acute lymphocytic leukemia 1 / P17542* / TAL bHLH transcription factor 1, erythroid differentiation factor*	ENSMUSG00000028717	29
Scx / Q64124 / scleraxis / Q7RTU7* / scleraxis bHLH transcription factor*	ENSMUSG00000034161	29
Lyl1 / P27792 / Protein lyl-1 / P12980* / LYL1, basic helix-loop-helix family member*	ENSMUSG00000034041	26
Hand2 / Q61039 / Heart- and neural crest derivatives-expressed protein 2 / P61296* / heart and neural crest derivatives expressed 2*	ENSMUSG00000038193	26
Hand1 / Q64279 / Heart- and neural crest derivatives-expressed protein 1 / O96004* / heart and neural crest derivatives expressed 1*	ENSMUSG00000037335	24
Tal2 / Q62282 / T cell acute lymphocytic leukemia 2 / Q16559* / TAL bHLH transcription factor 2*	ENSMUSG00000028417	23
Nhlh2 / Q64221 / nescient helix loop helix 2 / Q02577*	ENSMUSG00000048540	23
Nhlh1 / Q02576 / nescient helix loop helix 1 / Q02575*	ENSMUSG00000051251	23

Protein motifs (from Interpro)

Interpro ID	Name
IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
IPR036638	Helix-loop-helix DNA-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0043066	negative regulation of apoptotic process	IEA
biological_process	GO:0045668	negative regulation of osteoblast differentiation	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005730	nucleolus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
molecular_function	GO:0046983	protein dimerization activity	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000024	lowered ear position	"outer ears which are situated below the normal location " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Twist2^tm1(cre)Dor/Twist2^tm1(cre)Dor Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0000060	delayed bone ossification	"late onset of the formation of bone" [J:40203]	Show Allelic Composition: Lrp5^tm1.2Vari/Lrp5^tm1.2Vari Genetic Background: involves: 129S1/Sv Allelic Composition: Lrp6^tm1.1Vari/Lrp6^tm1.2Vari,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Fgfr2^tm1Dor/Fgfr2^tm1.1Dor,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129X1/SvJ Allelic Composition: Mmp14^tm1Stjw/Mmp14^tm1Stjw,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0000130	abnormal cancellous bone morphology	"structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Mef2c^tm1Eno/Mef2c⁺,Mef2d^tm1.1Eno/Mef2d⁺ Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Lrp5^tm1.1Vari/Lrp5^tm1.1Vari,Lrp6^tm1.1Vari/Lrp6^tm1.1Vari,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Lrp5^tm1.2Vari/Lrp5^tm1.2Vari,Lrp6^tm1.1Vari/Lrp6^tm1.1Vari,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000133	abnormal long bone metaphysis morphology	"malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295]	Show Allelic Composition: Fgfr2^tm1Dor/Fgfr2^tm1.1Dor,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129X1/SvJ
MP:0000137	abnormal vertebrae morphology	"malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Fgfr2^tm1Dor/Fgfr2^tm1.1Dor,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129X1/SvJ
MP:0000163	abnormal cartilage morphology	"anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lrp6^tm1.1Vari/Lrp6^tm1.2Vari,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Lrp5^tm1.2Vari/Lrp5^tm1.2Vari,Lrp6^tm1.1Vari/Lrp6^tm1.1Vari,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2Kem,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Mmp14^tm1Stjw/Mmp14^tm1Stjw,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0000165	abnormal hypertrophic chondrocyte zone	"anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]	Show Allelic Composition: Fgfr2^tm1Dor/Fgfr2^tm1.1Dor,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129X1/SvJ
MP:0000189	hypoglycemia	"low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0000259	abnormal vascular development	"malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]	Show Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: B6.129-Twist2^{tm1.1(cre)Dor} Pten^tm1Hwu
MP:0000352	decreased cell proliferation	"less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fgfr2^tm1Dor/Fgfr2^tm1.1Dor,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129X1/SvJ Allelic Composition: Adam17^tm1.1Wesh/Adam17^tm1.1Wesh,Tg(Scgb1a1-rtTA)2Jaw/0,Tg(tetO-cre)1Jaw/0,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
MP:0000377	abnormal hair follicle	"malformed invagination of the epidermis from which the hair shaft develops" [J:65031]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0000379	reduced hair follicle number	"fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0000414	alopecia	"absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]	Show Allelic Composition: Cebpa^tm1Dgt/Cebpa^tm1Dgt,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0 Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6
MP:0000416	sparse fur	"fur that is significantly less dense" [J:46854]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J Allelic Composition: Twist2^tm1(cre)Dor/Twist2^tm1(cre)Dor Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0000425	loss of cilia	"inability to retain the eyelashes " [J:45400]	Show Allelic Composition: Cebpa^tm1Dgt/Cebpa^tm1Dgt,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0 Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6
MP:0000428	abnormal craniofacial morphology	"anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cebpa^tm1Dgt/Cebpa^tm1Dgt,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0 Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6
MP:0000432	abnormal head morphology	"anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cebpa^tm1Dgt/Cebpa^tm1Dgt,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0 Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6
MP:0000438	abnormal skull morphology	"anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lrp5^tm1.1Vari/Lrp5^tm1.1Vari,Lrp6^tm1.1Vari/Lrp6^tm1.1Vari,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Lrp5^tm1.2Vari/Lrp5^tm1.2Vari,Lrp6^tm1.1Vari/Lrp6^tm1.1Vari,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000440	domed skull		Show Allelic Composition: Fgfr2^tm1Dor/Fgfr2^tm1.1Dor,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129X1/SvJ Allelic Composition: Mmp14^tm1Stjw/Mmp14^tm1Stjw,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0000445	short snout	"reduced length of the anterior facial part of the muzzle" [J:53370]	Show Allelic Composition: Mmp14^tm1Stjw/Mmp14^tm1Stjw,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0000474	abnormal foregut morphology	"malformed cephalic portion of the primitive digestive tube of the embryo" [J:35802]	Show Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo2^tm1Rilm/Robo2^tm1Rilm,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129 * 129X1/SvJ
MP:0000495	abnormal colon morphology	"malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0000496	abnormal small intestine morphology	"structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxb1^tm1Pgr/Foxb1^tm1Pgr Genetic Background: B6.129-Foxb1^tm1Pgr Allelic Composition: Fgfr1^tm1Jpa/Fgfr1⁺,Fgfr2^tm1Dor/Fgfr2^tm1.1Dor,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Fgfr1^tm1Jpa/Fgfr1^tm1.1Jpa,Fgfr2^tm1Dor/Fgfr2^tm1.1Dor,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000511	abnormal intestinal mucosa morphology	"structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0000512	intestinal ulcer	"lesions in the mucous lining of the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0000547	short limbs	"reduced average length of the extremities" [MGI:CLS, J:61509]	Show Allelic Composition: Mef2c^tm1Eno/Mef2c⁺,Mef2d^tm1.1Eno/Mef2d⁺ Genetic Background: involves: 129S7/SvEvBrd
MP:0000607	abnormal hepatocyte morphology	"malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0000689	abnormal spleen morphology	"atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0000703	abnormal thymus morphology	"anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0000759	abnormal skeletal muscle morphology	"anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J Allelic Composition: Twist1^tm1Bhr/Twist1⁺,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129/Sv * 129X1/SvJ
MP:0001146	abnormal testis morphology	"anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Tmem79^{tm1.1(KOMP)Wtsi}/Tmem79^{tm1.1(KOMP)Wtsi} Genetic Background: C57BL/6N-Tmem79^{tm1.1(KOMP)Wtsi}/J
MP:0001147	small testis	"reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]	Show Allelic Composition: Tmem79^{tm1.1(KOMP)Wtsi}/Tmem79^{tm1.1(KOMP)Wtsi} Genetic Background: C57BL/6N-Tmem79^{tm1.1(KOMP)Wtsi}/J
MP:0001175	abnormal lung morphology	"malformed organ of respiration" [J:35802]	Show Allelic Composition: Lcn2^tm1Mrgr/Lcn2^tm1Mrgr Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: B6.129-Twist2^{tm1.1(cre)Dor} Pten^tm1Hwu Allelic Composition: Kdr^tm1Jrt/Kdr⁺,Pten^tm1Hwu/Pten^tm1Hwu,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: B6.129-Twist2^{tm1.1(cre)Dor} Kdr^tm1Jrt Pten^tm1Hwu
MP:0001176	abnormal lung development	"malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Sms,Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Nfib^tm2Rmg/Nfib^tm2Rmg,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: B6.129-Twist2^{tm1.1(cre)Dor} Pten^tm1Hwu
MP:0001178	pulmonary hypoplasia	"reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Sms,Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
MP:0001182	lung hemorrhage	"bleeding in the respiratory organs" [J:66345]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Sms,Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
MP:0001199	thin skin	"reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J Allelic Composition: Twist2^tm1(cre)Dor/Twist2^tm1(cre)Dor Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0001212	skin lesions	"focal patches of inflammation on the skin" [J:30162]	Show Allelic Composition: Twist2^tm1(cre)Dor/Twist2^tm1(cre)Dor Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0001221	epidermal atrophy	"wasting of the epidermal layer of the skin" [J:65033]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0001242	hyperkeratosis	"increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0001243	abnormal dermal layer morphology	"malformed or atypical condition of the dermal layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]	Show Allelic Composition: Cebpa^tm1Dgt/Cebpa^tm1Dgt,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0 Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6
MP:0001244	thin dermal layer	"reduced thickness of the dermis" [J:65030]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Mmp14^tm1Stjw/Mmp14^tm1Stjw,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Lrp5^tm1.1Vari/Lrp5^tm1.1Vari,Lrp6^tm1.1Vari/Lrp6^tm1.1Vari,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Lrp5^tm1.2Vari/Lrp5^tm1.2Vari,Lrp6^tm1.1Vari/Lrp6^tm1.1Vari,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Mmp14^tm1Stjw/Mmp14^tm1Stjw,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0001575	cyanosis	"a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]	Show Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: B6.129-Twist2^{tm1.1(cre)Dor} Pten^tm1Hwu
MP:0001622	abnormal vasculogenesis	"aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kdr^tm1Jrt/Kdr⁺,Pten^tm1Hwu/Pten^tm1Hwu,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: B6.129-Twist2^{tm1.1(cre)Dor} Kdr^tm1Jrt Pten^tm1Hwu
MP:0001652	colonic necrosis	"pathologic death of cells within, or a portion of, the colon" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0001663	abnormal digestive system physiology	"altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fgfr1^tm1Jpa/Fgfr1⁺,Fgfr2^tm1Dor/Fgfr2^tm1.1Dor,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fgfr2^tm1Dor/Fgfr2^tm1.1Dor,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129X1/SvJ Allelic Composition: Mmp14^tm1Stjw/Mmp14^tm1Stjw,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0001914	hemorrhage	"loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: B6.129-Twist2^{tm1.1(cre)Dor} Pten^tm1Hwu
MP:0001919	abnormal reproductive system physiology	"anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^tm2(Sp8)Lma/Gt(ROSA)26Sor⁺,Sp8^tm1Smb/Sp8^tm1Smb,Tg(Msx2-cre)5Rem/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0001953	respiratory failure	"cessation of or failure to commence breathing" [MGI:cls, J:60159]	Show Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo2^tm1Rilm/Robo2^tm1Rilm,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129 * 129X1/SvJ
MP:0001954	respiratory distress	"physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Mef2c^tm1Eno/Mef2c⁺,Mef2d^tm1.1Eno/Mef2d⁺ Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: B6.129-Twist2^{tm1.1(cre)Dor} Pten^tm1Hwu
MP:0002058	neonatal lethality	"death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo2^tm1Rilm/Robo2^tm1Rilm,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129 * 129X1/SvJ
MP:0002073	abnormal hair growth	"absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cebpa^tm1Dgt/Cebpa^tm1Dgt,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0 Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mmp14^tm1Stjw/Mmp14^tm1Stjw,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0002092	abnormal eye morphology	"abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cebpa^tm1Dgt/Cebpa^tm1Dgt,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0 Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6
MP:0002109	abnormal limb morphology	"abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lrp5^tm1.1Vari/Lrp5^tm1.1Vari,Lrp6^tm1.1Vari/Lrp6^tm1.1Vari,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Lrp5^tm1.2Vari/Lrp5^tm1.2Vari,Lrp6^tm1.1Vari/Lrp6^tm1.1Vari,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002113	abnormal skeleton development	"anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tbx1^tm1Bem/Tbx1^tm1Bem Genetic Background: involves: 129/Sv * C57BL/6J * FVB * SJL Allelic Composition: Ctnna1^tm1Efu/Ctnna1^tm1Efu,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129X1/SvJ
MP:0002114	abnormal axial skeleton morphology	"abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tbx1^tm1Bem/Tbx1^tm1Bem Genetic Background: involves: 129/Sv * C57BL/6J * FVB * SJL
MP:0002133	abnormal respiratory system physiology	"anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lcn2^tm1Mrgr/Lcn2^tm1Mrgr Genetic Background: involves: 129 * C57BL/6
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hip1^tm2.1Tsr/Hip1^tm2.1Tsr Genetic Background: involves: 129X1/SvJ Allelic Composition: Hdac8^tm1.1Eno/Y,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL Allelic Composition: Snai1^tm1.1Stjw/Snai1^tm1.1Stjw,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: B6.129(SJL)-Twist2^{tm1.1(cre)Dor} Snai1^tm1.1Stjw
MP:0002264	abnormal bronchus morphology	"any structural anomaly of of the upper conducting airways of the lung; these airways arise from the terminus of the trachea " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Cd44^tm1Mak/Cd44⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0002357	abnormal spleen white pulp morphology	"anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0002371	abnormal thymus cortex morphology	"anomalous structure or development of the outer area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0002375	abnormal thymus medulla morphology	"anomalous structure or development of the inner area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0002427	dwarfism	"abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tbx1^tm1Bem/Tbx1^tm1Bem Genetic Background: involves: 129/Sv * C57BL/6J * FVB * SJL
MP:0002764	short tibia	" reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Mef2c^tm1Eno/Mef2c⁺,Mef2d^tm1.1Eno/Mef2d⁺ Genetic Background: involves: 129S7/SvEvBrd
MP:0002765	short fibula	"reduced length of the lateral and smaller of bone of the lower leg" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:12736]	Show Allelic Composition: Mef2c^tm1Eno/Mef2c⁺,Mef2d^tm1.1Eno/Mef2d⁺ Genetic Background: involves: 129S7/SvEvBrd
MP:0002932	abnormal joint	"defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Fgfr2^tm1Dor/Fgfr2^tm1.1Dor,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129X1/SvJ Allelic Composition: Lrp5^tm1.2Vari/Lrp5^tm1.2Vari,Lrp6^tm1.1Vari/Lrp6^tm1.1Vari,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2Kem,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Mmp14^tm1Stjw/Mmp14^tm1Stjw,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0003047	abnormal thoracic vertebrae morphology	"malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgfr2^tm1Dor/Fgfr2^tm1.1Dor,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129X1/SvJ
MP:0003048	abnormal cervical vertebrae morphology	"malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgfr2^tm1Dor/Fgfr2^tm1.1Dor,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129X1/SvJ
MP:0003109	short femur	"reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Fgfr2^tm1Dor/Fgfr2^tm1.1Dor,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129X1/SvJ
MP:0003120	abnormal tracheal cartilage	"any structural anomaly of the cartilaginous structures that support the trachea" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:97123]	Show Allelic Composition: Cd44^tm1Mak/Cd44⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0003190	fused synovial joints	"partial or complete absence of separations containing synovial fluid between bones" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93028]	Show Allelic Composition: Ctnnb1^tm1Yy/Ctnnb1^tm1Yy,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MP:0003380	abnormal intestine regeneration	"deviation from the normal ability of the intestine to regenerate healthy tissue following injury" [J:93428, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0003409	decreased width of hypertrophic chondrocyte zone	"decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Blnk^tm1Dkit/Blnk^tm1Dkit,Prkcd^tm1Kin/Prkcd^tm1Kin Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB Allelic Composition: Lrp5^tm1.2Vari/Lrp5^tm1.2Vari,Lrp6^tm1.1Vari/Lrp6^tm1.1Vari,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ctnna1^tm1Efu/Ctnna1^tm1Efu,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129X1/SvJ
MP:0003420	delayed intramembranous bone ossification	"late onset of bone formation in bones that form without a cartilagenous intermediate including the cranium and clavicle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]	Show Allelic Composition: Ctnna1^tm1Efu/Ctnna1^tm1Efu,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129X1/SvJ Allelic Composition: Mmp14^tm1Stjw/Mmp14^tm1Stjw,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0003641	small lung	"reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Sms,Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
MP:0003644	thymus atrophy	"wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0003795	abnormal bone structure		Show Allelic Composition: Lrp5^tm1.1Vari/Lrp5^tm1.1Vari,Lrp6^tm1.1Vari/Lrp6^tm1.1Vari,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Lrp5^tm1.2Vari/Lrp5^tm1.2Vari,Lrp6^tm1.1Vari/Lrp6^tm1.1Vari,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2Kem,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0003869	ectopic cartilage	"positional abnormality of cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Lrp5^tm1.1Vari/Lrp5^tm1.1Vari,Lrp6^tm1.1Vari/Lrp6^tm1.1Vari,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Lrp5^tm1.2Vari/Lrp5^tm1.2Vari,Lrp6^tm1.1Vari/Lrp6^tm1.1Vari,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2Kem,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0003924	herniated diaphragm	"protrusion of abdominal contents into the thoracic cavity through the diaphragm" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo2^tm1Rilm/Robo2^tm1Rilm,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129 * 129X1/SvJ
MP:0004007	abnormal lung vasculature	"malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: B6.129-Twist2^{tm1.1(cre)Dor} Pten^tm1Hwu Allelic Composition: Adam17^tm1.1Wesh/Adam17^tm1.1Wesh,Tg(Scgb1a1-rtTA)2Jaw/0,Tg(tetO-cre)1Jaw/0,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
MP:0004320	split sternum	"the appearance of an abnormal division in the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lrp5^tm1.1Vari/Lrp5^tm1.1Vari,Lrp6^tm1.1Vari/Lrp6^tm1.1Vari,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Lrp5^tm1.2Vari/Lrp5^tm1.2Vari,Lrp6^tm1.1Vari/Lrp6^tm1.1Vari,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2Kem,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0004337	clavicle hypoplasia	"underdevelopment or reduced size, usually due to a reduced number of cells, of one or both of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Runx2^tm1Mjo/Runx2⁺,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0004384	small interparietal bone	"reduced size of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Runx2^tm1Mjo/Runx2⁺,Twist1^tm1Bhr/Twist1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0004551	decreased tracheal cartilage ring number	"less than the 16-20 incomplete rings of hyaline cartilage forming the skeleton of the trachea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd44^tm1Mak/Cd44⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0004606	absent vertebral spinous process	"missing the dorsal projection of the vertebral arch that projects backward and downward from the junction of the laminae, and serves for the attachment of muscles and ligaments" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Fgfr2^tm1Dor/Fgfr2^tm1.1Dor,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129X1/SvJ
MP:0004841	abnormal small intestine crypts of Lieberkuhn morphology	"any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Fgfr1^tm1Jpa/Fgfr1^tm1.1Jpa,Fgfr2^tm1Dor/Fgfr2^tm1.1Dor,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004842	abnormal large intestine crypts of Lieberkuhn morphology	"any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0004882	enlarged lung	"increased size of the lung compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfib^tm2Rmg/Nfib^tm2Rmg,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0004989	decreased osteoblast cell number	"reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgfr2^tm1Dor/Fgfr2^tm1.1Dor,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129X1/SvJ
MP:0005006	abnormal osteoblast function	"anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fgfr2^tm1Dor/Fgfr2^tm1.1Dor,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129X1/SvJ
MP:0005150	cachexia	"general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J Allelic Composition: Twist1^tm1Bhr/Twist1⁺,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129/Sv * 129X1/SvJ
MP:0005225	abnormal vertebrae development	"anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fgfr2^tm1Dor/Fgfr2^tm1.1Dor,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129X1/SvJ
MP:0005323	dystonia	"impairment of muscle tone resulting in prolonged muscle contraction and involuntary movements such as repetitive movements, or twisting or writhing of the limbs" [J:84533]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0005439	decreased glycogen level	"less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0005508	abnormal skeleton morphology	"malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lrp5^tm1.1Vari/Lrp5^tm1.1Vari,Lrp6^tm1.1Vari/Lrp6^tm1.1Vari,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Lrp5^tm1.2Vari/Lrp5^tm1.2Vari,Lrp6^tm1.1Vari/Lrp6^tm1.1Vari,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2Kem,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0006236	absent meibomian glands	"missing meibomian glands" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Twist2^tm1(cre)Dor/Twist2^tm1(cre)Dor Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0006320	abnormal interscapular fat pad	"any structural anomaly of the encapsulated adipose tissue located between the scapulae" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0006395	abnormal epiphyseal plate morphology	"any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352]	Show Allelic Composition: Lrp5^tm1.1Vari/Lrp5^tm1.1Vari,Lrp6^tm1.1Vari/Lrp6^tm1.1Vari,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Lrp5^tm1.2Vari/Lrp5^tm1.2Vari,Lrp6^tm1.1Vari/Lrp6^tm1.1Vari,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0008271	abnormal bone ossification	"any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]	Show Allelic Composition: Blnk^tm1Dkit/Blnk^tm1Dkit,Prkcd^tm1Kin/Prkcd^tm1Kin Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB Allelic Composition: Lrp5^tm1.1Vari/Lrp5^tm1.1Vari,Lrp6^tm1.1Vari/Lrp6^tm1.1Vari,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Lrp5^tm1.2Vari/Lrp5^tm1.2Vari,Lrp6^tm1.1Vari/Lrp6^tm1.1Vari,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Mmp14^tm1Stjw/Mmp14^tm1Stjw,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0008272	abnormal endochondral bone ossification	"anomaly in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]	Show Allelic Composition: Mef2c^tm1Eno/Mef2c⁺,Mef2d^tm1.1Eno/Mef2d⁺ Genetic Background: involves: 129S7/SvEvBrd
MP:0008274	failure of bone ossification	"failure to initiate or a block in the process of the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]	Show Allelic Composition: Lrp5^tm1.2Vari/Lrp5^tm1.2Vari,Lrp6^tm1.1Vari/Lrp6^tm1.1Vari,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2Kem,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0008275	failure of endochondral bone ossification	"failure to initiate or a block in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]	Show Allelic Composition: Mef2c^tm1Eno/Mef2c⁺,Mef2d^tm1.1Eno/Mef2d⁺ Genetic Background: involves: 129S7/SvEvBrd
MP:0008395	abnormal osteoblast differentiation	"atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J Allelic Composition: Twist2^tm1(cre)Dor/Twist2⁺,Wnt7b^tm1Parr/Wnt7b^tm2Amc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Lrp5^tm1.2Vari/Lrp5^tm1.2Vari,Lrp6^tm1.1Vari/Lrp6^tm1.1Vari,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0008396	abnormal osteoclast differentiation	"atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgfr2^tm1Dor/Fgfr2^tm1.1Dor,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129X1/SvJ
MP:0008537	increased susceptibility to induced colitis	"increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0008751	abnormal interleukin level	"deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0008752	abnormal tumor necrosis factor level	"deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0008843	absent subcutaneous adipose tissue	"absence of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0008844	decreased subcutaneous adipose tissue amount	"reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Twist2^tm1(cre)Dor/Twist2^tm1(cre)Dor Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0009116	abnormal brown fat cell morphology	"any structural anomaly of cells from the thermogenic form of adipose tissue found in newborns of many species, including humans, and in hibernating mammals; brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation; brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria" [CL:0000449, GO:0050873, MESH:A.10.165.114.322]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0009250	abnormal appendicular skeleton morphology	"any structural anomaly of the bones of the limbs, shoulder and pelvic girdles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Fgfr2^tm1Dor/Fgfr2^tm1.1Dor,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129X1/SvJ
MP:0009571	abnormal right lung accessory lobe morphology		Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Sms,Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
MP:0009572	abnormal right lung cranial lobe morphology		Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Sms,Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
MP:0009573	abnormal right lung middle lobe morphology		Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Sms,Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0010678	abnormal skin adnexa morphology	"any structural anomaly of the tissue or structures associated with or embedded in the skin such as hair and hair follicles, sweat glands, sebaceous glands and claws or nails" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Twist2^tm1(cre)Dor/Twist2^tm1(cre)Dor Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0010743	delayed suture closure	"late onset of the fusion of the bones of the skull" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mmp14^tm1Stjw/Mmp14^tm1Stjw,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0010825	abnormal lung saccule morphology	"any structural anomaly of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [GO:0060430, ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfib^tm2Rmg/Nfib^tm2Rmg,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 Allelic Composition: Adam17^tm1.1Wesh/Adam17^tm1.1Wesh,Tg(Scgb1a1-rtTA)2Jaw/0,Tg(tetO-cre)1Jaw/0,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
MP:0010856	dilated respiratory conducting tubes	"expansion or widening of the lumens of the tubes of the respiratory system that allow passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd44^tm1Mak/Cd44⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0010880	small esophagus	"reduced size of the part of the digestive canal through which food passes from the pharynx to the stomach" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo2^tm1Rilm/Robo2^tm1Rilm,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129 * 129X1/SvJ
MP:0010975	abnormal lung lobe morphology	"any structural anomaly of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls of connective tissue)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Sms,Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Tgfbr2^tm1.2Hlm/Tgfbr2^tm1.2Hlm,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0010976	small lung lobe	"reduced size of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls of connective tissue)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Sms,Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
MP:0010988	abnormal bronchial cartilage morphology	"any structural anomaly of the hyaline cartilaginous structures that support the bronchi, present as irregular rings in the larger bronchi (and not as regular as in the trachea), and as small plates and islands in the smaller bronchi; as the branching continues through the bronchial tree, the amount of hyaline cartilage in the walls decreases until it is absent in the smallest bronchioles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tgfbr2^tm1.2Hlm/Tgfbr2^tm1.2Hlm,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0011024	abnormal branching involved in lung morphogenesis	"anomaly in the process in which the branched structure of the respiratory airway tree is generated and organized" [MGI:csmith]	Show Allelic Composition: Tgfbr2^tm1.2Hlm/Tgfbr2^tm1.2Hlm,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0011028	impaired branching involved in bronchus morphogenesis		Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Sms,Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Mef2c^tm1Eno/Mef2c⁺,Mef2d^tm1.1Eno/Mef2d⁺ Genetic Background: involves: 129S7/SvEvBrd
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Lrp5^tm1.1Vari/Lrp5^tm1.1Vari,Lrp6^tm1.1Vari/Lrp6^tm1.1Vari,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Lrp5^tm1.2Vari/Lrp5^tm1.2Vari,Lrp6^tm1.1Vari/Lrp6^tm1.1Vari,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: B6.129-Twist2^{tm1.1(cre)Dor} Pten^tm1Hwu
MP:0011088	partial neonatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Twist1^tm1Bhr/Twist1⁺,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129/Sv * 129X1/SvJ
MP:0011089	complete perinatal lethality	"death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Nfib^tm2Rmg/Nfib^tm2Rmg,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Tgfbr2^tm1.2Hlm/Tgfbr2^tm1.2Hlm,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0011109	partial lethality throughout fetal growth and development	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: B6.129-Twist2^{tm1.1(cre)Dor} Pten^tm1Hwu
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Prom2^{tm1.1(KOMP)Vlcg}/Prom2⁺ Genetic Background: C57BL/6N-Prom2^{tm1.1(KOMP)Vlcg}/J
MP:0011142	abnormal lung-associated mesenchyme development	"abnormality in the formation of the lung tissue comprised of multiple cell types (including connective tissue, endothelial cells, lymphatics, smooth muscle cells surrounding airways and blood vessels, myofibroblasts involved in septum formation, and cartilage-forming cells in the trachea), with most cells thought to be derived from the splanchnic mesenchyme, and other cells (endothelial, smooth muscle) believed to invade the lung as it expands; lung mesenchyme is a critical determinant of the shape and size of the developing lung, the extent and patterning of epithelial branching, and the formation of the pulmonary vasculature and interstitial mesenchymal components of the adult lung" [MGI:anna, PMID:18533146, PMID:20048339]	Show Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: B6.129-Twist2^{tm1.1(cre)Dor} Pten^tm1Hwu
MP:0011156	abnormal hypodermis fat layer morphology	"any structural anomaly of the superficial portion of the subcutaneous tissue which is specialized for fat storage" [ISBN:0-683-40008-8]	Show Allelic Composition: Mmp14^tm1Stjw/Mmp14^tm1Stjw,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0011237	decreased blood oxygen capacity	"a decrease in the maximum amount of oxygen that will combine chemically with a given amount of hemoglobin in a unit volume of blood" [ISBN:0-683-40008-8]	Show Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: B6.129-Twist2^{tm1.1(cre)Dor} Pten^tm1Hwu
MP:0011712	absent osteoblast differentiation		Show Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2Kem,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0011772	genital tubercle hypoplasia	"underdevelopment or reduced size of the embryonic anlage of the external genitalia, usually due to a reduced number of cells" [MGI:anna]	Show Allelic Composition: Fgfr1^tm1Jpa/Fgfr1^tm1Jpa,Fgfr2^tm1Dor/Fgfr2^tm1Dor,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0013389	Meibomian gland hypoplasia	"underdevelopment or reduced size of the meibum-secreting modified lobulated sebaceous glands located at the rim of the eyelids inside the tarsal plate, usually due to a reduced number of cells" [MGI:Anna]	Show Allelic Composition: Twist2^tm1(cre)Dor/Twist2^tm1(cre)Dor Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0020148	abnormal sensitivity to induced morbidity/mortality	"anomaly in the amount of an external agent required to cause death or diseased state" [GOC:NV]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0030009	increased bone marrow adipose tissue amount	"increased quantity of the bone marrow fat-storing cells/tissue" [PMID:27094502]	Show Allelic Composition: Mmp14^tm1Stjw/Mmp14^tm1Stjw,Twist2^{tm1.1(cre)Dor}/Twist2⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0030191	narrow snout	"decreased width of the anterior facial part of the face or muzzle containing the oral and nasal regions" [MGI:anna]	Show Allelic Composition: Twist2^tm1(cre)Dor/Twist2^tm1(cre)Dor Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0030393	delayed fontanelle closure	"late onset of closure of one or more of the membranous intervals at the margins of cranial bones" [MGI:anna]	Show Allelic Composition: Runx2^tm1Mjo/Runx2⁺,Twist2^tm1(cre)Dor/Twist2^tm1(cre)Dor Genetic Background: involves: 129X1/SvJ * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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