ENSMUSG00000007837


Mus musculus

Features
Gene ID: ENSMUSG00000007837
  
Biological name :Prrg2
  
Synonyms : proline-rich Gla (G-carboxyglutamic acid) polypeptide 2 / Prrg2 / Q8R182
  
Possible biological names infered from orthology : O14669 / proline rich and Gla domain 2
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B3
Gene start: 45053584
Gene end: 45062677
  
Corresponding Affymetrix probe sets: 10563068 (MoGene1.0st)   1424329_a_at (Mouse Genome 430 2.0 Array)   1432763_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147380
Ensembl peptide - ENSMUSP00000148121
Ensembl peptide - ENSMUSP00000148057
Ensembl peptide - ENSMUSP00000148014
Ensembl peptide - ENSMUSP00000147977
Ensembl peptide - ENSMUSP00000147844
Ensembl peptide - ENSMUSP00000147709
Ensembl peptide - ENSMUSP00000147598
Ensembl peptide - ENSMUSP00000007981
NCBI entrez gene - 65116     See in Manteia.
MGI - MGI:1929596
RefSeq - XM_017312220
RefSeq - NM_022999
RefSeq - XM_006541062
RefSeq - XM_006541063
RefSeq - XM_006541064
RefSeq - XM_011250888
RefSeq - XM_017312219
RefSeq Peptide - NP_075375
swissprot - Q8R182
swissprot - A0A1B0GSK7
swissprot - A0A1B0GS92
swissprot - A0A1B0GRY0
swissprot - A0A1B0GRN8
swissprot - A0A1B0GR55
swissprot - A0A1B0GSY3
swissprot - A0A1B0GSS9
Ensembl - ENSMUSG00000007837
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prrg2ENSDARG00000087193Danio rerio
 PRRG2ENSG00000126460Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prrg4 / Q8BGN6 / proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) / Q9BZD6* / proline rich and Gla domain 4*ENSMUSG0000002717131
Prrg1 / proline rich and Gla domain 1 / O14668*ENSMUSG0000004799625
Prrg3 / Q6PAQ9 / Transmembrane gamma-carboxyglutamic acid protein 3 / Q9BZD7* / proline rich and Gla domain 3*ENSMUSG0000003336122


Protein motifs (from Interpro)
Interpro ID Name
 IPR000294  Gamma-carboxyglutamic acid-rich (GLA) domain
 IPR017857  Coagulation factor-like, Gla domain superfamily
 IPR035972  Gamma-carboxyglutamic acid-rich (GLA) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0008150 biological_process ND
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane TAS
 molecular_functionGO:0004252 serine-type endopeptidase activity IBA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Prpf31tm1a(EUCOMM)Wtsi/Prpf31tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Prpf31tm1a(EUCOMM)Wtsi/Nju

 MP:0004646 decreased cervical vertebrae number "reduced number of the seven bony segments of the spine located anterior to the thoracic vertebrae and caudal to the skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Prpf31tm1a(EUCOMM)Wtsi/Prpf31tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Prpf31tm1a(EUCOMM)Wtsi/Nju

 MP:0004651 increased thoracic vertebrae number "increased number of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Prpf31tm1a(EUCOMM)Wtsi/Prpf31tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Prpf31tm1a(EUCOMM)Wtsi/Nju

 MP:0008810 increased circulating iron level "elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prpf31tm1a(EUCOMM)Wtsi/Prpf31tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Prpf31tm1a(EUCOMM)Wtsi/Nju

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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