ENSMUSG00000009596


Mus musculus

Features
Gene ID: ENSMUSG00000009596
  
Biological name :Taf7l
  
Synonyms : Q9D3R9 / Taf7l / Transcription initiation factor TFIID subunit 7-like
  
Possible biological names infered from orthology : Q5H9L4 / TATA-box binding protein associated factor 7 like
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: E3
Gene start: 134460118
Gene end: 134476490
  
Corresponding Affymetrix probe sets: 10606674 (MoGene1.0st)   1420433_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000009740
Ensembl peptide - ENSMUSP00000108849
NCBI entrez gene - 74469     See in Manteia.
MGI - MGI:1921719
RefSeq - XM_006528615
RefSeq - NM_028958
RefSeq - XM_006528611
RefSeq - XM_006528613
RefSeq - XM_006528614
RefSeq - XM_006528610
RefSeq Peptide - NP_083234
swissprot - Q9D3R9
swissprot - B1AV36
Ensembl - ENSMUSG00000009596
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TAF7LENSG00000102387Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
4933416C03Rik / RIKEN cDNA 4933416C03 gene / TAF7L* / Q5H9L4* / TATA-box binding protein associated factor 7 like*ENSMUSG0000007473447
Taf7 / Q9R1C0 / Transcription initiation factor TFIID subunit 7 / Q15545* / TATA-box binding protein associated factor 7*ENSMUSG0000005131634


Protein motifs (from Interpro)
Interpro ID Name
 IPR006751  TAFII55 protein, conserved region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030317 flagellated sperm motility IMP
 biological_processGO:0051123 RNA polymerase II transcriptional preinitiation complex assembly IBA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005669 transcription factor TFIID complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003713 transcription coactivator activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IBA
 molecular_functionGO:0035035 histone acetyltransferase binding IBA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IBA


Pathways (from Reactome)
Pathway description
RNA Polymerase II Pre-transcription Events
Regulation of TP53 Activity through Phosphorylation
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Initiation And Promoter Clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000733 abnormal muscle development "anomalous differentiation of muscle tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lpin1fld/Lpin1fld
Genetic Background: BALB/cByJ-Lpin1fld

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lpin1fld/Lpin1fld
Genetic Background: BALB/cByJ-Lpin1fld

Allelic Composition: Taf7ltm1.1Jw/Y
Genetic Background: 129X1.Cg-Taf7ltm1.1Jw

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lpin1fld/Lpin1fld
Genetic Background: BALB/cByJ-Lpin1fld

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Lpin1fld/Lpin1fld
Genetic Background: BALB/cByJ-Lpin1fld

Allelic Composition: Taf7ltm1.1Jw/Y
Genetic Background: 129X1.Cg-Taf7ltm1.1Jw

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
Show

Allelic Composition: Lpin1fld/Lpin1fld
Genetic Background: BALB/cByJ-Lpin1fld

Allelic Composition: Taf7ltm1.1Jw/Y
Genetic Background: 129X1.Cg-Taf7ltm1.1Jw

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lpin1fld/Lpin1fld
Genetic Background: BALB/cByJ-Lpin1fld

Allelic Composition: Taf7ltm1.1Jw/Y
Genetic Background: 129X1.Cg-Taf7ltm1.1Jw

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lpin1fld/Lpin1fld
Genetic Background: BALB/cByJ-Lpin1fld

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lpin1fld/Lpin1fld
Genetic Background: BALB/cByJ-Lpin1fld

Allelic Composition: Taf7ltm1.1Jw/Y
Genetic Background: 129X1.Cg-Taf7ltm1.1Jw

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lpin1fld/Lpin1fld
Genetic Background: BALB/cByJ-Lpin1fld

Allelic Composition: Taf7ltm1.1Jw/Y
Genetic Background: 129X1.Cg-Taf7ltm1.1Jw

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Lpin1fld/Lpin1fld
Genetic Background: BALB/cByJ-Lpin1fld

Allelic Composition: Taf7ltm1.1Jw/Y
Genetic Background: 129X1.Cg-Taf7ltm1.1Jw

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lpin1fld/Lpin1fld
Genetic Background: BALB/cByJ-Lpin1fld

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lpin1fld/Lpin1fld
Genetic Background: BALB/cByJ-Lpin1fld

Allelic Composition: Taf7ltm1.1Jw/Y
Genetic Background: 129X1.Cg-Taf7ltm1.1Jw

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lpin1fld/Lpin1fld
Genetic Background: BALB/cByJ-Lpin1fld

Allelic Composition: Taf7ltm1.1Jw/Y
Genetic Background: 129X1.Cg-Taf7ltm1.1Jw

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Lpin1fld/Lpin1fld
Genetic Background: BALB/cByJ-Lpin1fld

 MP:0009137 decreased brown fat lipid droplet number "reduction in the number of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lpin1fld/Lpin1fld
Genetic Background: BALB/cByJ-Lpin1fld

 MP:0009237 kinked sperm flagellum "a sharp bend or zigzag in the sperm tail" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lpin1fld/Lpin1fld
Genetic Background: BALB/cByJ-Lpin1fld

Allelic Composition: Taf7ltm1.1Jw/Y
Genetic Background: 129X1.Cg-Taf7ltm1.1Jw

 MP:0009243 hairpin sperm flagellum "a structural alteration where the sperm flagellum becomes bent back (folded) on itself to form a hairpin (loop) structure; a sharp hairpin-like bend formation can disrupt the axial structures and cause the sperm tail to become kinked" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lpin1fld/Lpin1fld
Genetic Background: BALB/cByJ-Lpin1fld

Allelic Composition: Taf7ltm1.1Jw/Y
Genetic Background: 129X1.Cg-Taf7ltm1.1Jw

 MP:0009295 decreased interscapular fat pad weight 
Show

Allelic Composition: Lpin1fld/Lpin1fld
Genetic Background: BALB/cByJ-Lpin1fld

 MP:0011170 abnormal brown fat cell differentiation "abnormal or arrest of differentiation of cells from the thermogenic form of adipose tissue found in newborns of many species, including humans, and in hibernating mammals" [CL:0000449, MGI:csmith]
Show

Allelic Composition: Lpin1fld/Lpin1fld
Genetic Background: BALB/cByJ-Lpin1fld

 MP:0011699 abnormal brown adipose tissue thermogenesis "any anomaly in the process of heat production in brown adipocytes" [MGI:smb]
Show

Allelic Composition: Lpin1fld/Lpin1fld
Genetic Background: BALB/cByJ-Lpin1fld

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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