ENSMUSG00000010067


Mus musculus

Features
Gene ID: ENSMUSG00000010067
  
Biological name :Rassf1
  
Synonyms : Q99MK9 / Ras association (RalGDS/AF-6) domain family member 1 / Rassf1
  
Possible biological names infered from orthology : Q9NS23 / Ras association domain family member 1
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F1
Gene start: 107551555
Gene end: 107562267
  
Corresponding Affymetrix probe sets: 10588669 (MoGene1.0st)   1441737_s_at (Mouse Genome 430 2.0 Array)   1448855_at (Mouse Genome 430 2.0 Array)   1456994_at (Mouse Genome 430 2.0 Array)   1457788_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000010211
Ensembl peptide - ENSMUSP00000117722
Ensembl peptide - ENSMUSP00000113252
Ensembl peptide - ENSMUSP00000091301
NCBI entrez gene - 56289     See in Manteia.
MGI - MGI:1928386
RefSeq - XM_006511770
RefSeq - NM_001243748
RefSeq - NM_019713
RefSeq Peptide - NP_001230677
RefSeq Peptide - NP_062687
swissprot - Q99MK9
swissprot - D6REH3
swissprot - A9YZW8
swissprot - B0QZV7
Ensembl - ENSMUSG00000010067
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rassf1ENSDARG00000004840Danio rerio
 RASSF1ENSGALG00000038951Gallus gallus
 Q9NS23ENSG00000068028Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q5EBH1 / Rassf5 / Ras association domain-containing protein 5 / Q8WWW0* / Ras association domain family member 5*ENSMUSG0000002643044
Q99P51 / Rassf3 / Ras association domain-containing protein 3 / Q86WH2* / Ras association domain family member 3*ENSMUSG0000002579528


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR011524  SARAH domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR033600  Ras association domain-containing protein 1
 IPR033614  C-terminal RASSF family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest ISS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007265 Ras protein signal transduction ISS
 biological_processGO:0031398 positive regulation of protein ubiquitination ISO
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0050821 protein stabilization ISS
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization IEA
 biological_processGO:0071157 negative regulation of cell cycle arrest ISS
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0015630 microtubule cytoskeleton ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity ISO
 molecular_functionGO:0047485 protein N-terminus binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nrp1tm1Ddg/Nrp1tm1Ddg,Nrp2tm1Ddg/Nrp2tm1Ddg
Genetic Background: involves: 129P2/OlaHsd

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
Show

Allelic Composition: Nrp1tm1Ddg/Nrp1tm1Ddg,Nrp2tm1Ddg/Nrp2tm1Ddg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Rassf1tm1Gpp/Rassf1+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3.1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hey1tm2Gess/Hey1tm2Gess
Genetic Background: B6.129-Hey1tm2Gess

 MP:0002957 intestinal adenocarcinoma "malignant neoplasm of epithelial cells in the intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3.1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003324 liver adenoma "benign epithelial neoplasm of the liver" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Sav1tm1.1Gpp/Sav1+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Rassf1tm1Gpp/Rassf1tm1Gpp,Sav1tm1.1Gpp/Sav1+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Sav1tm1.1Gpp/Sav1+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Rassf1tm1Gpp/Rassf1tm1Gpp,Sav1tm1.1Gpp/Sav1+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ

 MP:0003992 increased mortality induced by ionizing radiation "greater sensitivity to doses of ionizing radiation that include ultraviolet light, X-rays, or gamma rays" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3.1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004486 decreased response of heart to induced stress "decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nrp1tm1Ddg/Nrp1tm1Ddg,Nrp2tm1Ddg/Nrp2tm1Ddg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Rassf1tm1Gpp/Rassf1+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0004500 increased incidence of ionizing radiation-induced tumors "higher than normal frequency of tumor incidence induced by radiation in which the individual particle or photon carries sufficient energy to completely remove an electron from its orbit; common types of this radiation include gamma-rays and X-rays" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3.1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

 MP:0004839 bile duct hyperplasia "overdevelopment or increased size of the bile ducts, usually due to an increase in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rassf1tm1Gpp/Rassf1tm1Gpp,Sav1tm1.1Gpp/Sav1+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3.1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sav1tm1.1Gpp/Sav1+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Rassf1tm1Gpp/Rassf1tm1Gpp,Sav1tm1.1Gpp/Sav1+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ

 MP:0010040 abnormal oval cell morphology "any structural anomaly of adult liver-specific stem cells; a blast-like cell capable of self renewal and multipotent differentiation, the oval cell is capable of differentiating into mature hepatocytes or cholangiocytes" [PMID:16237666]
Show

Allelic Composition: Sav1tm1.1Gpp/Sav1+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Rassf1tm1Gpp/Rassf1tm1Gpp,Sav1tm1.1Gpp/Sav1+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ

 MP:0010054 hepatoblastoma "a malignant neoplasm occurring primarily in the liver and composed of tissue resembling embryonic or fetal hepatic epithelium, or mixed epithelial and mesenchymal tissues" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rassf1tm1Gpp/Rassf1tm1Gpp,Sav1tm1.1Gpp/Sav1+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ

 MP:0010383 increased adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C04.557.470.035]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3.1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3.1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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