ENSMUSG00000010592


Mus musculus

Features
Gene ID: ENSMUSG00000010592
  
Biological name :Dazl
  
Synonyms : Dazl / Deleted in azoospermia-like / Q64368
  
Possible biological names infered from orthology : Q92904
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: C
Gene start: 50279394
Gene end: 50293599
  
Corresponding Affymetrix probe sets: 10451721 (MoGene1.0st)   1419542_at (Mouse Genome 430 2.0 Array)   1449502_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000010736
NCBI entrez gene - 13164     See in Manteia.
MGI - MGI:1342328
RefSeq - XM_006523583
RefSeq - NM_001277863
RefSeq - NM_010021
RefSeq Peptide - NP_034151
RefSeq Peptide - NP_001264792
swissprot - Q64368
Ensembl - ENSMUSG00000010592
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dazlENSDARG00000036214Danio rerio
 DAZLENSGALG00000011243Gallus gallus
 DAZLENSG00000092345Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Boll / Q924M5 / Protein boule-like / Q8N9W6* / boule homolog, RNA binding protein*ENSMUSG0000002597728


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR034779  Deleted in azoospermia-like
 IPR035979  RNA-binding domain superfamily
 IPR037366  BOULE/DAZ family
 IPR037551  DAZ, RNA recognition motif, vertebrates


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001556 oocyte maturation IMP
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0007147 female meiosis II IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007281 germ cell development IMP
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045836 positive regulation of meiotic nuclear division IMP
 biological_processGO:0045948 positive regulation of translational initiation IEA
 biological_processGO:0048477 oogenesis IEA
 biological_processGO:0070935 3"-UTR-mediated mRNA stabilization IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005844 polysome IDA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IEA
 molecular_functionGO:0003730 mRNA 3"-UTR binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008494 translation activator activity IDA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dazltm1Hjc/Dazl+,Pum2Gt(XE772)Byg/Pum2Gt(XE772)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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