ENSMUSG00000010760


Mus musculus

Features
Gene ID: ENSMUSG00000010760
  
Biological name :Phlda2
  
Synonyms : O08969 / Phlda2 / Pleckstrin homology-like domain family A member 2
  
Possible biological names infered from orthology : Q53GA4
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F5
Gene start: 143501545
Gene end: 143503150
  
Corresponding Affymetrix probe sets: 10569437 (MoGene1.0st)   1417837_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146883
Ensembl peptide - ENSMUSP00000010904
NCBI entrez gene - 22113     See in Manteia.
MGI - MGI:1202307
RefSeq - NM_009434
RefSeq - XM_006508597
RefSeq Peptide - NP_033460
swissprot - A0A140LIM7
swissprot - O08969
Ensembl - ENSMUSG00000010760
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 phlda2ENSDARG00000042874Danio rerio
 PHLDA2ENSG00000181649Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Phlda1 / Q62392 / Pleckstrin homology-like domain family A member 1 / Q8WV24*ENSMUSG0000002020539
Phlda3 / Q9WV95 / Pleckstrin homology-like domain family A member 3 / Q9Y5J5*ENSMUSG0000004180137


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001890 placenta development IDA
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0010468 regulation of gene expression IDA
 biological_processGO:0030334 regulation of cell migration IDA
 biological_processGO:0045995 regulation of embryonic development IDA
 biological_processGO:0060721 regulation of spongiotrophoblast cell proliferation IMP
 biological_processGO:0070873 regulation of glycogen metabolic process IDA
 biological_processGO:1903547 regulation of growth hormone activity IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003123 paternal imprinting "specific loci are inactivated during spermatogenesis and are not expressed in offspring " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator, llw2:Linda Washburn, Mouse Genome Informatics Curator]
Show

Allelic Composition: Zbtb16lu/Zbtb16lu
Genetic Background: Not Specified

Allelic Composition: Phlda2tm2Bty/Phlda2tm2Bty
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004920 increased placenta weight "increase in the weight of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zbtb16lu/Zbtb16lu
Genetic Background: Not Specified

Allelic Composition: Phlda2tm2Bty/Phlda2tm2Bty
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Phlda2tm1Bty/Phlda2tm1Bty,Phlda3tm1Bty/Phlda3tm1Bty
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Phlda2tm2Bty/Phlda2tm2Bty,Phlda3tm1Bty/Phlda3tm1Bty
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004921 decreased placenta weight "reduction in the weight of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Phlda2tm2Bty/Phlda2tm2Bty
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm2Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Phlda2tm2Bty/Phlda2tm2Bty
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm1Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm2Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0012098 increased spongiotrophoblast size "greater size of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [MGI:csmith]
Show

Allelic Composition: Zbtb16lu/Zbtb16lu
Genetic Background: Not Specified

Allelic Composition: Phlda2tm2Bty/Phlda2tm2Bty
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm1Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm2Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0012108 increased trophoblast glycogen cell number "greater number of the glycogen-accumulating trophoblast cells that arise in the junctional zone of the placenta" [MGI:csmith]
Show

Allelic Composition: Zbtb16lu/Zbtb16lu
Genetic Background: Not Specified

Allelic Composition: Phlda2tm2Bty/Phlda2tm2Bty
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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