ENSMUSG00000011008


Mus musculus

Features
Gene ID: ENSMUSG00000011008
  
Biological name :Mcoln2
  
Synonyms : Mcoln2 / Mucolipin-2 / Q8K595
  
Possible biological names infered from orthology : Q8IZK6
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: H2
Gene start: 146149833
Gene end: 146195513
  
Corresponding Affymetrix probe sets: 10496771 (MoGene1.0st)   1431705_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000011152
Ensembl peptide - ENSMUSP00000096125
Ensembl peptide - ENSMUSP00000128900
NCBI entrez gene - 68279     See in Manteia.
MGI - MGI:1915529
RefSeq - XM_011240210
RefSeq - NM_001005846
RefSeq - NM_026656
RefSeq - XM_006501969
RefSeq - XM_011240209
RefSeq Peptide - NP_001005846
RefSeq Peptide - NP_080932
swissprot - Q8K595
swissprot - F7B2J7
Ensembl - ENSMUSG00000011008
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mcoln2ENSDARG00000098918Danio rerio
 MCOLN2ENSGALG00000008722Gallus gallus
 MCOLN2ENSG00000153898Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mcoln3 / Q8R4F0 / mucolipin 3 / Q8TDD5*ENSMUSG0000003685351
Mcoln1 / Q99J21 / Mucolipin-1 / Q9GZU1*ENSMUSG0000000456746


Protein motifs (from Interpro)
Interpro ID Name
 IPR013122  Polycystin cation channel, PKD1/PKD2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0032722 positive regulation of chemokine production IMP
 biological_processGO:0035926 chemokine (C-C motif) ligand 2 secretion IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0051259 protein complex oligomerization IDA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0071639 positive regulation of monocyte chemotactic protein-1 production IMP
 biological_processGO:0071642 positive regulation of macrophage inflammatory protein 1 alpha production IMP
 biological_processGO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production IMP
 biological_processGO:1905517 macrophage migration IMP
 biological_processGO:1990266 neutrophil migration IMP
 biological_processGO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production IMP
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0055037 recycling endosome IDA
 cellular_componentGO:0055038 recycling endosome membrane IEA
 molecular_functionGO:0005262 calcium channel activity IEA


Pathways (from Reactome)
Pathway description
TRP channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002419 abnormal innate immunity "anomaly in the function of the early phase of the response to infection; normally, it is present at all times, does not increase with exposure to specific pathogens, and does not discriminate between pathogens" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Clcn7tm2.1Mjec/Clcn7tm2.1Mjec
Genetic Background: C.129(Cg)-Clcn7tm2.1Mjec

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Clcn7tm2.1Mjec/Clcn7tm2.1Mjec
Genetic Background: C.129(Cg)-Clcn7tm2.1Mjec

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clcn7tm2.1Mjec/Clcn7tm2.1Mjec
Genetic Background: C.129(Cg)-Clcn7tm2.1Mjec

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
Show

Allelic Composition: Clcn7tm2.1Mjec/Clcn7tm2.1Mjec
Genetic Background: C.129(Cg)-Clcn7tm2.1Mjec

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
Show

Allelic Composition: Clcn7tm2.1Mjec/Clcn7tm2.1Mjec
Genetic Background: C.129(Cg)-Clcn7tm2.1Mjec

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr