ENSMUSG00000011114


Mus musculus

Features
Gene ID: ENSMUSG00000011114
  
Biological name :Tbrg1
  
Synonyms : Q3UB74 / Tbrg1 / Transforming growth factor beta regulator 1
  
Possible biological names infered from orthology : Q3YBR2
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A4
Gene start: 37648763
Gene end: 37657312
  
Corresponding Affymetrix probe sets: 10592342 (MoGene1.0st)   1452648_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000150375
Ensembl peptide - ENSMUSP00000112600
NCBI entrez gene - 21376     See in Manteia.
MGI - MGI:1100877
RefSeq - NM_025289
RefSeq Peptide - NP_079565
swissprot - A0A1L1STM2
swissprot - Q3UB74
Ensembl - ENSMUSG00000011114
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tbrg1ENSDARG00000074996Danio rerio
 TBRG1ENSG00000154144Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003888  FY-rich, N-terminal
 IPR003889  FY-rich, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication ISS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0050821 protein stabilization ISS
 biological_processGO:1990173 protein localization to nucleoplasm ISS
 cellular_componentGO:0005634 nucleus ISS
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Celsr1ctb/Celsr1ctb
Genetic Background: CByJ.Cg-Celsr1ctb/GrsrJ

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Celsr1ctb/Celsr1ctb
Genetic Background: CByJ.Cg-Celsr1ctb/GrsrJ

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Celsr1ctb/Celsr1ctb
Genetic Background: CByJ.Cg-Celsr1ctb/GrsrJ

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Celsr1ctb/Celsr1ctb
Genetic Background: CByJ.Cg-Celsr1ctb/GrsrJ

 MP:0002947 hemangioma "proliferation of blood vessels leading to a mass that resembles a neoplasm" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87544]
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Allelic Composition: Celsr1ctb/Celsr1ctb
Genetic Background: CByJ.Cg-Celsr1ctb/GrsrJ

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Celsr1ctb/Celsr1ctb
Genetic Background: CByJ.Cg-Celsr1ctb/GrsrJ

 MP:0008478 increased spleen white pulp amount "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Celsr1ctb/Celsr1ctb
Genetic Background: CByJ.Cg-Celsr1ctb/GrsrJ

 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Celsr1ctb/Celsr1ctb
Genetic Background: CByJ.Cg-Celsr1ctb/GrsrJ

Allelic Composition: Tbrg1tm1a(KOMP)Wtsi/Tbrg1+
Genetic Background: C57BL/6N-Tbrg1tm1a(KOMP)Wtsi

 MP:0013329 abnormal preputial gland morphology "any structural anomaly of the paired, lobulated, modified sebaceous glands located in the inguinal region adjacent to the penis and vagina, with pheromonal functions in male rodents; in males, the preputial gland empties into the preputial cavity and in females, the preputial (aka clitoral) gland duct empties into the clitoral fossa" [MGI:Anna]
Show

Allelic Composition: Celsr1ctb/Celsr1ctb
Genetic Background: CByJ.Cg-Celsr1ctb/GrsrJ

 MP:0013538 increased Harderian gland adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the Harderian gland, occurring in a specific population in a given time period " [MGI:Anna]
Show

Allelic Composition: Celsr1ctb/Celsr1ctb
Genetic Background: CByJ.Cg-Celsr1ctb/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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