ENSMUSG00000012396


Mus musculus

Features
Gene ID: ENSMUSG00000012396
  
Biological name :Nanog
  
Synonyms : Nanog / Nanog homeobox / Q80Z64
  
Possible biological names infered from orthology : Nanog homeobox retrogene P8 / NANOGP8 / Q9H9S0
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: F1
Gene start: 122707489
Gene end: 122714633
  
Corresponding Affymetrix probe sets: 10541524 (MoGene1.0st)   1429388_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000012540
Ensembl peptide - ENSMUSP00000108199
Ensembl peptide - ENSMUSP00000108200
NCBI entrez gene - 71950     See in Manteia.
MGI - MGI:1919200
RefSeq - XM_011241473
RefSeq - NM_001289828
RefSeq - NM_001289830
RefSeq - NM_001289831
RefSeq - NM_028016
RefSeq - XM_006506651
RefSeq Peptide - NP_001276759
RefSeq Peptide - NP_001276760
RefSeq Peptide - NP_082292
RefSeq Peptide - NP_001276757
swissprot - Q80Z64
swissprot - A2RS90
Ensembl - ENSMUSG00000012396
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NANOGENSGALG00000027772Gallus gallus
 NANOGENSG00000111704Homo sapiens
 NANOGP8ENSG00000255192Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001710 mesodermal cell fate commitment IGI
 biological_processGO:0001714 endodermal cell fate specification ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISO
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008283 cell proliferation ISO
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0008406 gonad development IEP
 biological_processGO:0009880 embryonic pattern specification IEP
 biological_processGO:0010033 response to organic substance IDA
 biological_processGO:0010454 negative regulation of cell fate commitment IGI
 biological_processGO:0010468 regulation of gene expression ISO
 biological_processGO:0017145 stem cell division IDA
 biological_processGO:0019827 stem cell population maintenance IEP
 biological_processGO:0030514 negative regulation of BMP signaling pathway IDA
 biological_processGO:0032526 response to retinoic acid IDA
 biological_processGO:0035019 somatic stem cell population maintenance ISO
 biological_processGO:0042664 negative regulation of endodermal cell fate specification TAS
 biological_processGO:0043697 cell dedifferentiation IDA
 biological_processGO:0045595 regulation of cell differentiation ISO
 biological_processGO:0045596 negative regulation of cell differentiation IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045931 positive regulation of mitotic cell cycle IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048863 stem cell differentiation IMP
 biological_processGO:2000035 regulation of stem cell division IDA
 biological_processGO:2000036 regulation of stem cell population maintenance IGI
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005730 nucleolus ISO
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0001010 transcription factor activity, sequence-specific DNA-binding transcription factor recruiting IDA
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0003714 transcription corepressor activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002582 disorganized extraembryonic tissue "a lack of the regular arrangement of the membranes involved with the embryo s protection and nutrition" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptstm1Thny/Ptstm1Thny
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002583 absent extraembryonic ectoderm "missing layer of the endoderm of the extraembryonic tissue" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptstm1Thny/Ptstm1Thny
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002718 abnormal inner cell mass "malformed or absent cells of the blastocyst that develop into the body of the embryo" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fndc3btm1Maim/Fndc3btm1Maim
Genetic Background: involves: 129S2/SvPas

Allelic Composition: NanogGt(D047A12)Wrst/NanogGt(D047A12)Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010380 inner cell mass apoptosis "the cells of the blastocyst that develop into the body of the embryo are undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fndc3btm1Maim/Fndc3btm1Maim
Genetic Background: involves: 129S2/SvPas

Allelic Composition: NanogGt(D047A12)Wrst/NanogGt(D047A12)Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Ptstm1Thny/Ptstm1Thny
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: NanogGt(D042B07)Wrst/NanogGt(D042B07)Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: NanogGt(D047A12)Wrst/NanogGt(D047A12)Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011184 absent embryonic epiblast "absence of the tissue derived from the inner cell mass that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper and to the extraembryonic mesoderm" [PMID:21123814]
Show

Allelic Composition: Ptstm1Thny/Ptstm1Thny
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011185 absent primitive endoderm "absence of the monolayer of cells derived from and located on the surface of inner cell mass, directly facing the blastocoele, and is separated from the more centrally located epiblast by basal lamina; the primitive endoderm give rises to the visceral endoderm and the parietal endoderm" [PMID:21123814]
Show

Allelic Composition: NanogGt(D042B07)Wrst/NanogGt(D042B07)Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: NanogGt(D047A12)Wrst/NanogGt(D047A12)Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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