ENSMUSG00000012428


Mus musculus

Features
Gene ID: ENSMUSG00000012428
  
Biological name :Steap4
  
Synonyms : Metalloreductase STEAP4 / Q923B6 / Steap4
  
Possible biological names infered from orthology : Q687X5 / STEAP4 metalloreductase
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: A1
Gene start: 7960457
Gene end: 7982213
  
Corresponding Affymetrix probe sets: 10519497 (MoGene1.0st)   1425829_a_at (Mouse Genome 430 2.0 Array)   1460197_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000111081
NCBI entrez gene - 117167     See in Manteia.
MGI - MGI:1923560
RefSeq - NM_054098
RefSeq Peptide - NP_473439
swissprot - Q923B6
Ensembl - ENSMUSG00000012428
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 steap4ENSDARG00000055901Danio rerio
 STEAP4ENSGALG00000008997Gallus gallus
 Q687X5ENSG00000127954Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BWB6 / Steap2 / six transmembrane epithelial antigen of prostate 2 / Q8NFT2* / STEAP2 metalloreductase*ENSMUSG0000001565346
Steap3 / STEAP family member 3 / Q658P3* / STEAP3 metalloreductase*ENSMUSG0000002638944
Steap1 / Q9CWR7 / Metalloreductase STEAP1 / Q9UHE8* / Q6NZ63* / STEAP1B* / STEAP family member 1* / STEAP family member 1B*ENSMUSG0000001565225


Protein motifs (from Interpro)
Interpro ID Name
 IPR013130  Ferric reductase transmembrane component-like domain
 IPR028939  Pyrroline-5-carboxylate reductase, catalytic, N-terminal
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0015677 copper ion import IDA
 biological_processGO:0045444 fat cell differentiation IEP
 biological_processGO:0055072 iron ion homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IDA
 biological_processGO:0098706 ferric iron import across plasma membrane IDA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 molecular_functionGO:0008823 cupric reductase activity IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0052851 ferric-chelate reductase (NADPH) activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000180 abnormal circulating cholesterol level "anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Btbd9Gt(RRE078)Byg/Btbd9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Btbd9Gt(RRE078)Byg/Btbd9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Btbd9Gt(RRE078)Byg/Btbd9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Btbd9Gt(RRE078)Byg/Btbd9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lepob/Lepob,Steap4tm1Dgen/Steap4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Btbd9Gt(RRE078)Byg/Btbd9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002970 abnormal white fat morphology "structural aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Btbd9Gt(RRE078)Byg/Btbd9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Btbd9Gt(RRE078)Byg/Btbd9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
Show

Allelic Composition: Btbd9Gt(RRE078)Byg/Btbd9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Btbd9Gt(RRE078)Byg/Btbd9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Btbd9Gt(RRE078)Byg/Btbd9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Btbd9Gt(RRE078)Byg/Btbd9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Btbd9Gt(RRE078)Byg/Btbd9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
Show

Allelic Composition: Btbd9Gt(RRE078)Byg/Btbd9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lepob/Lepob,Steap4tm1Dgen/Steap4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Btbd9Gt(RRE078)Byg/Btbd9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lepob/Lepob,Steap4tm1Dgen/Steap4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Btbd9Gt(RRE078)Byg/Btbd9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Btbd9Gt(RRE078)Byg/Btbd9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010934 increased subcutaneous adipose tissue amount "increase in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Btbd9Gt(RRE078)Byg/Btbd9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0030017 decreased adipocyte glucose uptake "reduced ability of adipocytes to take in glucose" [MGI:anna]
Show

Allelic Composition: Btbd9Gt(RRE078)Byg/Btbd9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0030022 decreased muscle cell glucose uptake "reduced ability of muscle cells to take in glucose" [MGI:anna]
Show

Allelic Composition: Btbd9Gt(RRE078)Byg/Btbd9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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