ENSMUSG00000012819


Mus musculus

Features
Gene ID: ENSMUSG00000012819
  
Biological name :Cdh23
  
Synonyms : Cadherin-23 / Cdh23 / Q99PF4
  
Possible biological names infered from orthology : cadherin related 23 / Q9H251
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B4
Gene start: 60302748
Gene end: 60696490
  
Corresponding Affymetrix probe sets: 10369307 (MoGene1.0st)   10338541 (MoGene1.0st)   10339147 (MoGene1.0st)   10341723 (MoGene1.0st)   10342262 (MoGene1.0st)   10343411 (MoGene1.0st)   1432346_a_at (Mouse Genome 430 2.0 Array)   1452028_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101104
Ensembl peptide - ENSMUSP00000072973
Ensembl peptide - ENSMUSP00000101101
Ensembl peptide - ENSMUSP00000101102
Ensembl peptide - ENSMUSP00000101103
NCBI entrez gene - 22295     See in Manteia.
MGI - MGI:1890219
RefSeq - XM_017313927
RefSeq - XM_017313926
RefSeq - XM_017313928
RefSeq - NM_001252635
RefSeq - NM_023370
RefSeq - XM_017313930
RefSeq Peptide - NP_075859
RefSeq Peptide - NP_001239564
swissprot - Q99PF4
swissprot - F8WIF5
swissprot - E9Q7M6
swissprot - K4DI74
Ensembl - ENSMUSG00000012819
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdh23ENSDARG00000094454Danio rerio
 cdh23ENSDARG00000007561Danio rerio
 ENSGALG00000036824Gallus gallus
 ENSGALG00000004653Gallus gallus
 CDH23ENSG00000107736Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fat4 / Q2PZL6 / Protocadherin Fat 4 / Q6V0I7* / FAT atypical cadherin 4*ENSMUSG0000004674327
Fat1 / FAT atypical cadherin 1 / Q14517*ENSMUSG0000007004727
Fat3 / FAT atypical cadherin 3 / Q8TDW7*ENSMUSG0000007450526
Dchs1 / E9PVD3 / Protocadherin-16 / Q96JQ0* / dachsous cadherin-related 1*ENSMUSG0000003686225
Fat2 / Q5F226 / Protocadherin Fat 2 / Q9NYQ8* / FAT atypical cadherin 2*ENSMUSG0000005533325
Dchs2 / Mus musculus dachsous cadherin related 2 (Dchs2), mRNA.ENSMUSG0000010269224
Celsr1 / O35161 / Cadherin EGF LAG seven-pass G-type receptor 1 / Q9NYQ6*ENSMUSG0000001602815
Celsr2 / cadherin EGF LAG seven-pass G-type receptor 2 isoform 2 / Q9HCU4* / cadherin EGF LAG seven-pass G-type receptor 2*ENSMUSG0000006874015
Celsr3 / Q91ZI0 / Cadherin EGF LAG seven-pass G-type receptor 3 / Q9NYQ7*ENSMUSG0000002347314


Protein motifs (from Interpro)
Interpro ID Name
 IPR002126  Cadherin
 IPR015919  Cadherin-like
 IPR020894  Cadherin conserved site
 IPR033030  Cadherin-23


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006816 calcium ion transport ISO
 biological_processGO:0007155 cell adhesion TAS
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0007605 sensory perception of sound ISO
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ISS
 biological_processGO:0042472 inner ear morphogenesis IMP
 biological_processGO:0042491 inner ear auditory receptor cell differentiation IMP
 biological_processGO:0045494 photoreceptor cell maintenance ISO
 biological_processGO:0048563 post-embryonic animal organ morphogenesis IMP
 biological_processGO:0048839 inner ear development IMP
 biological_processGO:0050953 sensory perception of light stimulus ISO
 biological_processGO:0050957 equilibrioception ISO
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration ISO
 biological_processGO:0060088 auditory receptor cell stereocilium organization IMP
 biological_processGO:0060122 inner ear receptor cell stereocilium organization IMP
 cellular_componentGO:0001917 photoreceptor inner segment IDA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032420 stereocilium IDA
 cellular_componentGO:0032426 stereocilium tip IDA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0060091 kinocilium IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000023 abnormal ear distance/ position "anomaly in the space between or the placement of the outer ears " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atp8a2wl-2J/Atp8a2wl-2J
Genetic Background: involves: DBA/2JCri

 MP:0000026 abnormal inner ear morphology "malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Cdh23v-7J/Cdh23v-7J
Genetic Background: CByJ(Cg)-Cdh23v-7J/GrsrJ

 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
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Allelic Composition: Cdh23v-bus/Cdh23v-bus
Genetic Background: involves: KYF/MsIdr

 MP:0000042 abnormal organ of Corti "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Snrpntm2.1Kaj/Snrpn+,Alpltm1(cre)Nagy/Alpl+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cdh23v-bus/Cdh23v-bus
Genetic Background: involves: KYF/MsIdr

 MP:0000043 organ of Corti degeneration "a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdh23v-7J/Cdh23v-7J
Genetic Background: CByJ(Cg)-Cdh23v-7J/GrsrJ

Allelic Composition: Cdh23sals/Cdh23sals
Genetic Background: involves: C57BL/6J

Allelic Composition: Cdh23v-11J/Cdh23v-11J
Genetic Background: B6(Cg)-Cdh23v-11J/J

Allelic Composition: Cdh23ahl/Cdh23ahl
Genetic Background: C57BL/6J

Allelic Composition: Cdh23Jera/Cdh23Jera
Genetic Background: involves: C57BL/6

Allelic Composition: Cdh23v-df/Cdh23v-df
Genetic Background: Not Specified

Allelic Composition: Cdh2312J/Cdh2312J
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0000048 abnormal stria vascularis "anomalous structure of the layer of highly vascularized pigmented granular cells on the outer wall of the cochlear duct" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atp8a2wl-2J/Atp8a2wl-2J
Genetic Background: involves: DBA/2JCri

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdh23v/Cdh23v
Genetic Background: involves: fanciers stocks

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
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Allelic Composition: Cdh23v-bus/Cdh23v-bus
Genetic Background: KYF/MsIdr

 MP:0001388 abnormal stationary movement "altered ability or inability to change body posture or shift a body part" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adartm1Knk/Adartm1Knk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Cdh23v/Cdh23v
Genetic Background: involves: fanciers stocks

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Espnje/Espnje
Genetic Background: involves: fanciers stocks

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: at-42J/?
Genetic Background: C57BL/6J-at-42J

Allelic Composition: Cdh23v-J/Cdh23v-J
Genetic Background: B6.C-H2-Kbm1/ByJ

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Msh4tm1Wed/Msh4tm1Wed,Msh5tm1Rak/Msh5tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Cdh23v-9J/Cdh23v-9J
Genetic Background: C57BL/6J-Cdh23v-9J/J

Allelic Composition: Cdh23v-10J/Cdh23v-10J
Genetic Background: involves: BALB/cByJ * C57BL/6

Allelic Composition: Cdh23v-2J/Cdh23v-2J
Genetic Background: B6(V)-Cdh23v-2J/J

Allelic Composition: Cdh23v-7J/Cdh23v-7J
Genetic Background: CByJ(Cg)-Cdh23v-7J/GrsrJ

Allelic Composition: Cdh23v-ngt/Cdh23v-ngt
Genetic Background: involves: ICR * MSM

Allelic Composition: Cdh23v-5J/Cdh23v-5J
Genetic Background: SENCARA/PtJ

Allelic Composition: Cdh23v/Cdh23v
Genetic Background: involves: fanciers stocks

Allelic Composition: Cdh23v-11J/Cdh23v-11J
Genetic Background: B6(Cg)-Cdh23v-11J/J

Allelic Composition: Cdh23v-4J/Cdh23v-4J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Cdh23v-bus/Cdh23v-bus
Genetic Background: involves: KYF/MsIdr

 MP:0001395 bi-directional circling "circling behavior exhibited in both clockwise and counterclockwise directions" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdh23v-7J/Cdh23v-7J
Genetic Background: CByJ(Cg)-Cdh23v-7J/GrsrJ

Allelic Composition: Cdh23v-bus/Cdh23v-bus
Genetic Background: KYF/MsIdr

Allelic Composition: Cdh23v-4J/Cdh23v-4J
Genetic Background: involves: C57BLKS/J

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Cdh23v/Cdh23v
Genetic Background: involves: fanciers stocks

 MP:0001410 head bobbing "compulsive up and down movement of the head" [J:17123]
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Allelic Composition: Cdh23v-5J/Cdh23v-5J
Genetic Background: SENCARA/PtJ

Allelic Composition: Cdh23v-11J/Cdh23v-11J
Genetic Background: B6(Cg)-Cdh23v-11J/J

Allelic Composition: Cdh23v-4J/Cdh23v-4J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Cdh23m1Btlr/Cdh23m1Btlr
Genetic Background: C57BL/6J-Cdh23m1Btlr

 MP:0001442 decreased grooming behavior "reduced amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdh23v/Cdh23v
Genetic Background: involves: fanciers stocks

 MP:0001486 abnormal startle reflex "abberant threshold or reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Pjvksti/Pjvksti
Genetic Background: involves: C57BL/6J

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
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Allelic Composition: Cdh23v-2J/Cdh23v-2J
Genetic Background: B6(V)-Cdh23v-2J/J

Allelic Composition: Cdh23v/Cdh23v
Genetic Background: mixed

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdh23v-2J/Cdh23v-2J
Genetic Background: B6(V)-Cdh23v-2J/J

 MP:0001963 abnormal hearing "anomaly in the ability to receive auditory stimuli" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pjvksti/Pjvksti
Genetic Background: involves: C57BL/6J

 MP:0001967 deafness "inability to hear" [J:57651]
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Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdh23v-8J/Cdh23v-8J
Genetic Background: C57BL/6J-Cdh23v-8J/J

Allelic Composition: Cdh23v-9J/Cdh23v-9J
Genetic Background: C57BL/6J-Cdh23v-9J/J

Allelic Composition: Cdh23v-10J/Cdh23v-10J
Genetic Background: involves: BALB/cByJ * C57BL/6

Allelic Composition: Cdh23v-7J/Cdh23v-7J
Genetic Background: CByJ(Cg)-Cdh23v-7J/GrsrJ

Allelic Composition: Adgrv1frings/Adgrv1frings,Cdh23ahl/Cdh23ahl
Genetic Background: involves: BUB/BnJ * CAST/EiJ

Allelic Composition: Adgrv1frings/Adgrv1frings,Cdh23ahl/Cdh23ahl
Genetic Background: involves: BUB/BnJ * MOLD/RkJ

Allelic Composition: Atp2b2dfw-2J/Atp2b2+,Cdh23ahl/Cdh23ahl
Genetic Background: involves: CAST/Ei * BALB/cByJ

Allelic Composition: Atp2b2dfw-2J/Atp2b2+,Cdh23ahl/Cdh23ahl
Genetic Background: involves: BALB/cByJ * MOLF

Allelic Composition: Cdh23ahl/Cdh23ahl,Adgrv1frings/Adgrv1frings
Genetic Background: involves: BUB/BnJ * RB/1

Allelic Composition: Cdh23v-ngt/Cdh23v-ngt
Genetic Background: involves: ICR * MSM

Allelic Composition: Cdh23v-5J/Cdh23v-5J
Genetic Background: SENCARA/PtJ

Allelic Composition: Cdh23v/Cdh23+,Myo7ash1/Myo7a+
Genetic Background: involves: BALB

Allelic Composition: Cdh23v/Cdh23v
Genetic Background: involves: fanciers stocks

Allelic Composition: Cdh23v-11J/Cdh23v-11J
Genetic Background: B6(Cg)-Cdh23v-11J/J

Allelic Composition: Cdh23sals/Cdh23v-2J
Genetic Background: involves: C57BL/6J

Allelic Composition: Cdh23v-4J/Cdh23v-4J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Cdh2312J/Cdh2312J
Genetic Background: involves: C57BL/6J

Allelic Composition: Cdh23v-df/Cdh23v-df
Genetic Background: Not Specified

Allelic Composition: Cdh2312J/Cdh2312J
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp8a2wl-2J/Atp8a2wl-2J
Genetic Background: involves: DBA/2JCri

 MP:0002102 abnormal ear morphology "structural or developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdh23v-2J/Cdh23v-2J
Genetic Background: B6(V)-Cdh23v-2J/J

 MP:0002622 abnormal cochlear hair cell morphology "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdh23sals/Cdh23sals
Genetic Background: involves: C57BL/6J

Allelic Composition: Cdh23v-bus/Cdh23v-bus
Genetic Background: involves: KYF/MsIdr

 MP:0002730 head shaking "compulsive movement of the head in the horizontal plane" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:274]
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Allelic Composition: Cdh23v-ngt/Cdh23v-ngt
Genetic Background: involves: ICR * MSM

Allelic Composition: Cdh23v/Cdh23v
Genetic Background: involves: fanciers stocks

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cdh23v/Cdh23v
Genetic Background: involves: fanciers stocks

 MP:0002855 abnormal cochlear ganglion morphology "malformation, malfunction or absence of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdh23Jera/Cdh23Jera
Genetic Background: involves: C57BL/6

Allelic Composition: Cdh23v-bus/Cdh23v-bus
Genetic Background: involves: KYF/MsIdr

Allelic Composition: Cdh23v-df/Cdh23v-df
Genetic Background: Not Specified

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdh23v-7J/Cdh23v-7J
Genetic Background: CByJ(Cg)-Cdh23v-7J/GrsrJ

Allelic Composition: Cdh23sals/Cdh23sals
Genetic Background: involves: C57BL/6J

Allelic Composition: Cdh23v-2J/Cdh23+,Pcdh15av-3J/Pcdh15+
Genetic Background: C57BL/6J-Cdh23v-2J Pcdh15av-3J

Allelic Composition: Cdh23v/Cdh23v
Genetic Background: mixed

 MP:0002894 abnormal otoliths "malformed crystalline calciferous particles adhering to the otolithic membrane" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Cdh23v-J/Cdh23v-J
Genetic Background: B6.C-H2-Kbm1/ByJ

 MP:0003107 abnormal response to novelty "alteration in amount of exploration/investigation of a novel object, situation or environment" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Cdh23v/Cdh23v
Genetic Background: involves: fanciers stocks

 MP:0003308 abnormal cochlear sensory epithelium 
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Allelic Composition: Cdh23v-bus/Cdh23v-bus
Genetic Background: involves: KYF/MsIdr

 MP:0003637 cochlear ganglion hypoplasia "reduced numbers of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdh23ahl/Cdh23ahl
Genetic Background: C57BL/6J

 MP:0003866 abnormal defecation "anomaly in the production and excretion of feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdh23v/Cdh23v
Genetic Background: involves: fanciers stocks

 MP:0003878 abnormal ear physiology "anomolous function of the ear, not due to an anatomical defect" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:100987]
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Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdh23v-2J/Cdh23v-2J
Genetic Background: B6(V)-Cdh23v-2J/J

 MP:0004329 saccular degeneration "degeneration or loss of the smaller of the two sacs in the vestibule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23v-7J/Cdh23v-7J
Genetic Background: CByJ(Cg)-Cdh23v-7J/GrsrJ

 MP:0004331 saccular macula degeneration "degeneration or loss of the oval neuroepithelial sensory receptor in the anterior wall of the saccule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23v/Cdh23v
Genetic Background: mixed

 MP:0004362 cochlear hair cell degeneration "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23sals/Cdh23sals
Genetic Background: involves: C57BL/6J

Allelic Composition: Cdh23v-2J/Cdh23+,Pcdh15av-3J/Pcdh15+
Genetic Background: C57BL/6J-Cdh23v-2J Pcdh15av-3J

Allelic Composition: Cdh23v/Cdh23v
Genetic Background: mixed

Allelic Composition: Cdh23Jera/Cdh23Jera
Genetic Background: involves: C57BL/6

Allelic Composition: Cdh2312J/Cdh2312J
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Cdh23ahl/Cdh23ahl
Genetic Background: C57BL/6NJ

Allelic Composition: Cdh23ahl/Cdh23ahl,MahlC57BL/6J/MahlC57BL/6J
Genetic Background: 129S1.B6-(rs3696307-rs257098870)/Kjn

 MP:0004363 stria vascularis degeneration "degeneration or loss of the stratified, secretory epithelium which lines the upper part of the cochlear spiral ligament and maintains potassium ion homeostasis in the endolymph" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23v-7J/Cdh23v-7J
Genetic Background: CByJ(Cg)-Cdh23v-7J/GrsrJ

 MP:0004396 decreased cochlear inner hair cell number "decreased number (or less than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey2tm1Gess/Hey2tm1Gess
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cdh2312J/Cdh2312J
Genetic Background: involves: C57BL/6J

Allelic Composition: Cdh23tm1.1Kjn/Cdh23tm1.1Kjn
Genetic Background: 129S/Sv-Cdh23tm1.1Kjn/Kjn

 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh2312J/Cdh2312J
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Cdh23ahl/Cdh23ahl
Genetic Background: C57BL/6NJ

 MP:0004399 abnormal cochlear outer hair cell morphology "any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there are three rows of columnar outer hair cells largely surrounded by cortilymph and supporting phalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a V-shaped pattern extend from the cell s surface through the cuticular plate into the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdh23v-2J/Cdh23v-2J
Genetic Background: B6(V)-Cdh23v-2J/J

Allelic Composition: Cdh23v-ngt/Cdh23v-ngt
Genetic Background: involves: ICR * MSM

Allelic Composition: Cdh23tm1.2Ugds/Cdh23tm1.2Ugds
Genetic Background: involves: 129S1/SvImJ * BALB/c * C57BL/6

 MP:0004402 decreased cochlear outer hair cell number "decreased number (or less than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey2tm1Gess/Hey2tm1Gess
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cdh23v/Cdh23+,Myo7a4626SB/Myo7a+
Genetic Background: involves: BALB/cRl * 47BS/Rl * CBA/Ca

Allelic Composition: Cdh2312J/Cdh2312J
Genetic Background: involves: C57BL/6J

Allelic Composition: Cdh23tm1.1Kjn/Cdh23tm1.1Kjn
Genetic Background: 129S/Sv-Cdh23tm1.1Kjn/Kjn

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23Jera/Cdh23Jera
Genetic Background: involves: C57BL/6

Allelic Composition: Cdh2312J/Cdh2312J
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Cdh23ahl/Cdh23ahl
Genetic Background: C57BL/6NJ

 MP:0004408 decreased cochlear hair cell number "decreased number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23v-bus/Cdh23v-bus
Genetic Background: involves: KYF/MsIdr

Allelic Composition: Cdh23tm1.1Kjn/Cdh23tm1.1Kjn
Genetic Background: 129S/Sv-Cdh23tm1.1Kjn/Kjn

 MP:0004413 absent cochlear microphonics "absence or loss of the bioelectric potentials produced by the hair cells of the organ of Corti in response to sound" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23tm1.1Ugds/Cdh23tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0004415 abnormal cochlear nerve compound action potential "anomaly in the combined potentials resulting from activation of the auditory division of the eighth cranial nerve; these potentials represent the summed activity of multiple cochlear afferent fibers discharging synchronously and thus assess the combined functional state of OHCs, IHCs, and their primary afferent innervation" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey2tm1Gess/Hey2tm1Gess
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cdh23v/Cdh23+,Myo7a4626SB/Myo7a+
Genetic Background: involves: BALB/cRl * 47BS/Rl * CBA/Ca

 MP:0004431 abnormal hair cell mechanoelectric transduction "anomalous conversion of mechanical energy into electric(al) energy by sensory cells, such as auditory and vestibular hair cells, required for auditory sensation" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo15tm1.1(cre)Ugds/Myo15+,Ush1gtm1.1Ugds/Ush1gtm1.1Ugds
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0004432 abnormal cochlear hair cell physiology "anomalies in processes pertinent to the integrated function of cochlear hair cells i.e. the sensory cells in the spiral organ which are in synaptic contact with sensory as well as efferent fibers of the cochlear (auditory) nerve " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23sals/Cdh23sals
Genetic Background: involves: C57BL/6J

Allelic Composition: Cdh23v-2J/Cdh23v-2J
Genetic Background: involves: C57BL/6J

 MP:0004434 abnormal cochlear outer hair cell physiology "anomalies in processes pertinent to the function of cochlear OHCs which are known to enhance the performance of the cochlea, both qualitatively (increased selectivity) and quantitatively (increased sensitivity); in addition to the mechanoelectric transduction required for auditory sensation, OHCs also perform electromechanical transduction, whereby transmembrane voltage drives rapid changes in the length and stiffness of OHCs at audio frequencies in vitro (electromotility)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh2312J/Cdh2312J
Genetic Background: involves: C57BL/6J

 MP:0004491 abnormal orientation of outer hair cell stereociliary bundles "misorientation or rotation of outer hair cell (OHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23v-bus/Cdh23v-bus
Genetic Background: involves: KYF/MsIdr

 MP:0004492 abnormal orientation of inner hair cell stereociliary bundles "misorientation or rotation of inner hair cell (IHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23v-bus/Cdh23v-bus
Genetic Background: involves: KYF/MsIdr

 MP:0004515 abnormal vestibular hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical staircase-like arrangement of the mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of vestibular hair cells of the utricle and saccule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdh23v-2J/Cdh23v-2J
Genetic Background: B6(V)-Cdh23v-2J/J

 MP:0004521 abnormal cochlear hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical pattern of arrangement of mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh2312J/Cdh2312J
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0004522 abnormal orientation of cochlear hair cell stereociliary bundles "misorientation or rotation of inner and/or outer hair cell stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23v-2J/Cdh23v-2J
Genetic Background: B6(V)-Cdh23v-2J/J

 MP:0004523 decreased cochlear hair cell stereocilia number "decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh2312J/Cdh2312J
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0004527 abnormal outer hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical V or W-like pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear OHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest (outermost) row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdh23v-2J/Cdh23v-2J
Genetic Background: B6(V)-Cdh23v-2J/J

Allelic Composition: Cdh23v-ngt/Cdh23v-ngt
Genetic Background: involves: ICR * MSM

Allelic Composition: Cdh23v/Cdh23v
Genetic Background: involves: CBA/Ca

Allelic Composition: Cdh23v/Cdh23v,Myo7a4626SB/Myo7a+
Genetic Background: mixed

Allelic Composition: Cdh23v/Cdh23+,Myo7a4626SB/Myo7a4626SB
Genetic Background: mixed

Allelic Composition: Cdh23v/Cdh23v,Myo7a4626SB/Myo7a4626SB
Genetic Background: mixed

Allelic Composition: Cdh23v-2J/Cdh23+,Pcdh15av-3J/Pcdh15+
Genetic Background: C57BL/6J-Cdh23v-2J Pcdh15av-3J

Allelic Composition: Cdh23v/Cdh23+
Genetic Background: involves: BALB/cRl * 47BS/Rl * CBA/Ca

Allelic Composition: Cdh23v/Cdh23+,Myo7a4626SB/Myo7a+
Genetic Background: involves: BALB/cRl * 47BS/Rl * CBA/Ca

Allelic Composition: Cdh23tm1.2Ugds/Cdh23tm1.2Ugds
Genetic Background: involves: 129S1/SvImJ * BALB/c * C57BL/6

Allelic Composition: Cdh23tm1.1Ugds/Cdh23tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Cdh23v-bus/Cdh23v-bus
Genetic Background: involves: KYF/MsIdr

Allelic Composition: Cdh2312J/Cdh2312J
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0004529 decreased outer hair cell stereocilia number "decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdh23v-2J/Cdh23v-2J
Genetic Background: B6(V)-Cdh23v-2J/J

Allelic Composition: Cdh23v/Cdh23+
Genetic Background: involves: BALB/cRl * 47BS/Rl * CBA/Ca

Allelic Composition: Cdh23v/Cdh23+,Myo7a4626SB/Myo7a+
Genetic Background: involves: BALB/cRl * 47BS/Rl * CBA/Ca

Allelic Composition: Cdh23tm1.1Ugds/Cdh23tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0004530 absent outer hair cell stereocilia "complete absence of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdh23v-2J/Cdh23v-2J
Genetic Background: B6(V)-Cdh23v-2J/J

 MP:0004531 short outer hair cell stereocilia "reduced length of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23tm1.1Ugds/Cdh23tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0004532 abnormal inner hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typically linear or U-shaped pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear IHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdh23v-2J/Cdh23v-2J
Genetic Background: B6(V)-Cdh23v-2J/J

Allelic Composition: Cdh23v/Cdh23v
Genetic Background: involves: CBA/Ca

Allelic Composition: Cdh23v-2J/Cdh23+,Pcdh15av-3J/Pcdh15+
Genetic Background: C57BL/6J-Cdh23v-2J Pcdh15av-3J

Allelic Composition: Cdh23tm1.1Ugds/Cdh23tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Cdh23Jera/Cdh23Jera
Genetic Background: involves: C57BL/6

Allelic Composition: Cdh23v-bus/Cdh23v-bus
Genetic Background: involves: KYF/MsIdr

 MP:0004534 decreased inner hair cell stereocilia number "decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23tm1.1Ugds/Cdh23tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0004536 short inner hair cell stereocilia "reduced length of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23tm1.1Ugds/Cdh23tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0004577 abnormal cochlear hair cell inter-stereocilial links "any structural abnormality in the morphologically and biochemically distinct link types that extend between the stereocilia of cochlear hair bundles; link types can be distinguished by their relative sensitivities to treatment with calcium chelators and the protease subtilisin; in the mature mouse cochlea, tip links and horizontal top connectors are the only inter-stereocilial links associated with the hair bundle; ankle links and transient lateral links are both prominent features of developing auditory hair bundles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23v-2J/Cdh23v-2J
Genetic Background: B6(V)-Cdh23v-2J/J

 MP:0004578 abnormal cochlear hair bundle tip links "any structural abnormality in single, three-stranded interrow filaments that extend obliquely from the tip of one stereocilium to the lateral side of an adjacent taller stereocilium; in the mouse, tip links are already detectable prenatally and persist throughout life; tips links are thought to gate the mechanotransducer channel, are lost from the cell surface after exposure to either calcium chelator BAPTA or lanthanum, and resist degradation by the protease subtilisin" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23v-2J/Cdh23v-2J
Genetic Background: B6(V)-Cdh23v-2J/J

Allelic Composition: Cdh23sals/Cdh23sals
Genetic Background: involves: C57BL/6J

Allelic Composition: Cdh23tm1.1Ugds/Cdh23tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Cdh2312J/Cdh2312J
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0004597 increased susceptibility to noise-induced hearing loss "greater than normal reduction in hearing sensitivity following exposure to acute noise that is injurious to the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23v/Cdh23+
Genetic Background: involves: BALB/cRl * 47BS/Rl * CBA/Ca

 MP:0004736 abnormal distortion product otoacoustic emission "any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http://www.emedicine.com/ent/topic372.htm, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23Ahl+/Cdh23Ahl+,Ush2atm1Tili/Ush2atm1Tili
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CAST/EiJ * CBA/CaJ

Allelic Composition: Cdh2312J/Cdh2312J
Genetic Background: involves: C57BL/6J

Allelic Composition: Cdh2312J/Cdh2312J
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0004737 absent distortion product otoacoustic emissions "failure to create mechanical distortions in the inner ear when two primary tones are presented, indicating failure of outer hair cells to amplify basilar membrane motion" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23sals/Cdh23sals
Genetic Background: involves: C57BL/6J

Allelic Composition: Cdh23tm1.1Ugds/Cdh23tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Cdh2312J/Cdh2312J
Genetic Background: involves: C57BL/6J

 MP:0004738 abnormal brainstem auditory evoked potential "anomaly in the electrical activity generated in response to short tone bursts; may be used to evaluate sensorineural hearing function" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23v-8J/Cdh23v-8J
Genetic Background: C57BL/6J-Cdh23v-8J/J

Allelic Composition: Cdh23v-9J/Cdh23v-9J
Genetic Background: C57BL/6J-Cdh23v-9J/J

Allelic Composition: Cdh23v-10J/Cdh23v-10J
Genetic Background: involves: BALB/cByJ * C57BL/6

Allelic Composition: Cdh2312J/Cdh2312J
Genetic Background: involves: C57BL/6J

 MP:0004742 abnormal vestibular system physiology "any functional anomaly of the sensory system responsible for the sense of head position and movement of the body through space; such anomalies may include impaired balance, dizziness, poor regulation of postural muscle tone and inability to detect quick movements of the head " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: at-42J/?
Genetic Background: C57BL/6J-at-42J

 MP:0004748 increased susceptibility to age-related hearing loss "greater than normal loss of hearing associated with advancing age, manifest as reduced ability to perceive or discriminate sounds; the pattern and age of onset vary" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob,Npy5rtm1Rpa/Npy5rtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Atp2b2dfw-2J/Atp2b2+,Cdh23ahl/Cdh23ahl
Genetic Background: involves: CAST/Ei * BALB/cByJ

Allelic Composition: Cdh23ahl/Cdh23ahl,Adgrv1frings/Adgrv1frings
Genetic Background: involves: BUB/BnJ * RB/1

Allelic Composition: Cdh23v/Cdh23+
Genetic Background: mixed

Allelic Composition: Cdh23v-2J/Cdh23+
Genetic Background: mixed

Allelic Composition: Cdh23v/Cdh23+,Myo7a4626SB/Myo7a+
Genetic Background: mixed

Allelic Composition: Cdh23v-2J/Cdh23+,Myo7a4626SB/Myo7a+
Genetic Background: mixed

Allelic Composition: Cdh23v-2J/Cdh23+,Pcdh15av-3J/Pcdh15+
Genetic Background: C57BL/6J-Cdh23v-2J Pcdh15av-3J

Allelic Composition: Cdh23v/Cdh23+
Genetic Background: involves: BALB/cRl * 47BS/Rl * CBA/Ca

Allelic Composition: Fscn2ahl8/Fscn2ahl8,Cdh23ahl/Cdh23ahl
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Cdh23ahl/Cdh23ahl,mt-Trm1
Genetic Background: either: A/J X (A/J x CAST/Ei)F1 or A/J X (CAST/Ei x A/J)F1

Allelic Composition: Cdh23ahl/Cdh23ahl,mt-Trm2
Genetic Background: either: NOD/LtJ X (NOD/LtJ x CAST/Ei)F1 or SKH2/J X (SKH2/J x CAST/Ei)F1

 MP:0004813 absent linear vestibular evoked potential "absence of the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal s head)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23v-2J/Cdh23v-2J
Genetic Background: B6(V)-Cdh23v-2J/J

 MP:0005191 head tilt "condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdh23v-8J/Cdh23v-8J
Genetic Background: C57BL/6J-Cdh23v-8J/J

Allelic Composition: Cdh23v-10J/Cdh23v-10J
Genetic Background: involves: BALB/cByJ * C57BL/6

Allelic Composition: Cdh23v-bus/Cdh23v-bus
Genetic Background: involves: KYF/MsIdr

 MP:0005307 head tossing "compulsive flailing of the head in multiple directions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdh23v-7J/Cdh23v-7J
Genetic Background: CByJ(Cg)-Cdh23v-7J/GrsrJ

Allelic Composition: Cdh23v-J/Cdh23v-J
Genetic Background: B6.C-H2-Kbm1/ByJ

Allelic Composition: Cdh23v-bus/Cdh23v-bus
Genetic Background: involves: KYF/MsIdr

 MP:0005357 retropulsion "when placed in a new environment, mice will walk backwards and then may walk forwards, whereas wild type mice will immediately walk forward, or freeze momentarily and then walk forward" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:79604]
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Allelic Composition: Cdh23v-J/Cdh23v-J
Genetic Background: B6.C-H2-Kbm1/ByJ

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Cdh23v-2J/Cdh23v-2J
Genetic Background: B6(V)-Cdh23v-2J/J

Allelic Composition: Cdh23v/Cdh23v
Genetic Background: involves: CBA/Ca

Allelic Composition: Cdh23v/Cdh23v,Myo7a4626SB/Myo7a4626SB
Genetic Background: involves: 47BS/Rl * CBA/Ca

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23sals/Cdh23sals
Genetic Background: involves: C57BL/6J

Allelic Composition: Cdh23v/Cdh23+
Genetic Background: involves: BALB/cRl * 47BS/Rl * CBA/Ca

Allelic Composition: Cdh23tm1.1Ugds/Cdh23tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Cdh23Jera/Cdh23Jera
Genetic Background: involves: C57BL/6

Allelic Composition: Cdh2312J/Cdh2312J
Genetic Background: involves: C57BL/6J

 MP:0006335 abnormal hearing electrophysiology "anomaly in auditory function as it relates to electrical phenomena" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23tm1.1Ugds/Cdh23tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0006358 absent pinna reflex "complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23v-ngt/Cdh23v-ngt
Genetic Background: involves: ICR * MSM

Allelic Composition: Cdh23v/Cdh23+
Genetic Background: mixed

Allelic Composition: Cdh23v-2J/Cdh23+
Genetic Background: mixed

Allelic Composition: Cdh23v/Cdh23+,Myo7a4626SB/Myo7a+
Genetic Background: mixed

Allelic Composition: Cdh23v-2J/Cdh23+,Myo7a4626SB/Myo7a+
Genetic Background: mixed

Allelic Composition: Cdh2312J/Cdh2312J
Genetic Background: involves: C57BL/6J

Allelic Composition: Cdh23v-df/Cdh23v-df
Genetic Background: Not Specified

 MP:0006359 absent startle reflex "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23v-bus/Cdh23v-bus
Genetic Background: involves: KYF/MsIdr

 MP:0011061 abnormal inner hair cell kinocilium morphology "any structural anomaly of the nonmotile primary cilium that is found at the apical surface of inner hair cells" [GO:0060091]
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Allelic Composition: Cdh23v-2J/Cdh23v-2J
Genetic Background: B6(V)-Cdh23v-2J/J

 MP:0011062 abnormal outer hair cell kinocilium morphology "any structural anomaly of the nonmotile primary cilium that is found at the apical surface of outer hair cells" [GO:0060091]
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Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdh23v-2J/Cdh23v-2J
Genetic Background: B6(V)-Cdh23v-2J/J

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Cdh23v-2J/Cdh23v-2J
Genetic Background: B6(V)-Cdh23v-2J/J

Allelic Composition: Atp2b2dfw-2J/Atp2b2+,Cdh23ahl/Cdh23ahl
Genetic Background: involves: CAST/Ei * BALB/cByJ

Allelic Composition: Atp2b2dfw-2J/Atp2b2+,Cdh23ahl/Cdh23ahl
Genetic Background: involves: BALB/cByJ * MOLF

Allelic Composition: Cdh23sals/Cdh23sals
Genetic Background: involves: C57BL/6J

Allelic Composition: Cdh23v-6J/Cdh23v-6J
Genetic Background: B10.A-H2h4/(4R)SgDvEgJ-Cdh23v-6J/J

Allelic Composition: Cdh23v-2J/Cdh23+,Pcdh15av-3J/Pcdh15+
Genetic Background: C57BL/6J-Cdh23v-2J Pcdh15av-3J

Allelic Composition: Cdh23v-3J/Cdh23+
Genetic Background: C57BL/6J-Cdh23v-3J

Allelic Composition: Cdh23v-J/Cdh23v-J
Genetic Background: B6.C-H2-Kbm1/ByJ

Allelic Composition: Cdh23v-11J/Cdh23v-11J
Genetic Background: B6(Cg)-Cdh23v-11J/J

Allelic Composition: Fscn2ahl8/Fscn2ahl8,Cdh23ahl/Cdh23ahl
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Cdh23ahl/Cdh23ahl,mt-Trm1
Genetic Background: either: A/J X (A/J x CAST/Ei)F1 or A/J X (CAST/Ei x A/J)F1

Allelic Composition: Cdh23ahl/Cdh23ahl,mt-Trm2
Genetic Background: either: NOD/LtJ X (NOD/LtJ x CAST/Ei)F1 or SKH2/J X (SKH2/J x CAST/Ei)F1

Allelic Composition: Cdh23tm1.1Ugds/Cdh23tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Cdh23Jera/Cdh23Jera
Genetic Background: involves: C57BL/6

Allelic Composition: Cdh23Jera/Cdh23+
Genetic Background: involves: C57BL/6

Allelic Composition: Cdh23v-2J/Cdh23+,Myo7ash1-8J/Myo7a+
Genetic Background: B6.Cg-Myo7ash1-8J Cdh23v-2J

Allelic Composition: Cdh23v-2J/Cdh23+
Genetic Background: B6(V)-Cdh23v-2J/J

Allelic Composition: Cdh2312J/Cdh23v-2J
Genetic Background: involves: C57BL/6J

Allelic Composition: Cdh2312J/Cdh2312J
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Cdh23tm1.1Kjn/Cdh23tm1.1Kjn
Genetic Background: 129S/Sv-Cdh23tm1.1Kjn/Kjn

Allelic Composition: Cdh23ahl/Cdh23ahl,MahlC57BL/6J/MahlC57BL/6J
Genetic Background: 129S1.B6-(rs3696307-rs257098870)/Kjn

Allelic Composition: Cdh23ahl/Cdh23tm1.1Kjn,MahlC57BL/6J/Mahl129S1/SvImJ
Genetic Background: (129S1.B6-(rs3696307-rs257098870)/Kjn x 129S/Sv-Cdh23tm1.1Kjn/Kjn)F1

 MP:0012148 decreased a wave implicit time "decrease in the time from the onset of light stimulus to the peak of the a wave" [MGI:smb]
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Allelic Composition: Cdh23v-2J/Cdh23v-2J
Genetic Background: B6(V)-Cdh23v-2J/J

 MP:0012149 decreased b wave implicit time "decrease in the time from the onset of light stimulus to the peak of the b wave" [MGI:smb]
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Allelic Composition: Cdh23v-2J/Cdh23v-2J
Genetic Background: B6(V)-Cdh23v-2J/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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