ENSMUSG00000014543


Mus musculus

Features
Gene ID: ENSMUSG00000014543
  
Biological name :Klra17
  
Synonyms : Klra17
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F3
Gene start: 129831154
Gene end: 129876672
  
Corresponding Affymetrix probe sets: 10548437 (MoGene1.0st)   1425888_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000014687
Ensembl peptide - ENSMUSP00000114108
NCBI entrez gene - 170733     See in Manteia.
MGI - MGI:2180674
RefSeq - XM_006505664
RefSeq - NM_133203
RefSeq Peptide - NP_573466
swissprot - Q9JMA4
Ensembl - ENSMUSG00000014543
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Klra7 / Q60654 / Killer cell lectin-like receptor 7 ENSMUSG0000006759961
Klra5 / Q60652 / Killer cell lectin-like receptor 5 ENSMUSG0000003017360
Klra9ENSMUSG0000003302459
Klra6 / Q60653 / Killer cell lectin-like receptor 6 ENSMUSG0000006176959
Klra1ENSMUSG0000007985359
Klra10ENSMUSG0000007271858
Klra8 / Q60682 / Killer cell lectin-like receptor 8 ENSMUSG0000008972758
Klra3 / Q64329 / Killer cell lectin-like receptor 3 ENSMUSG0000006759157
Klra4 / Q60651 / Mus musculus killer cell lectin-like receptor, subfamily A, member 18 (Klra18), mRNA.ENSMUSG0000007985255
Klra2ENSMUSG0000003018749
Gm156 / Mus musculus predicted 156 (Gm156), transcript variant 2, mRNA.ENSMUSG0000007115819


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR013600  Ly49-like, N-terminal
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR033992  Natural killer cell receptor-like, C-type lectin-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0042288 MHC class I protein binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk,Rorctm2Litt/Rorc+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk,Rorctm2Litt/Rorc+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008524 increased plasmacytoid dendritic cell number "greater number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15596797]
Show

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk,Rorctm2Litt/Rorc+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008563 decreased interferon-alpha secretion "increase in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
Show

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk,Rorctm2Litt/Rorc+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008574 decreased circulating interferon-alpha level "reduction in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
Show

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk,Rorctm2Litt/Rorc+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008618 decreased circulating interleukin-12 level "reduction in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk,Rorctm2Litt/Rorc+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk,Rorctm2Litt/Rorc+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008769 abnormal plasmacytoid dendritic cell physiology "any functional anomaly of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli; plasmacytoid dendritic cells are found in the thymic medulla and lymph node T cell areas and are responsible for immune tolerance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk,Rorctm2Litt/Rorc+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr