ENSMUSG00000015165


Mus musculus

Features
Gene ID: ENSMUSG00000015165
  
Biological name :Hnrnpl
  
Synonyms : Heteroous nuclear ribonucleoprotein L / Hnrnpl / Q8R081
  
Possible biological names infered from orthology : heterogeneous nuclear ribonucleoprotein L / P14866
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B1
Gene start: 28808541
Gene end: 28822266
  
Corresponding Affymetrix probe sets: 10551600 (MoGene1.0st)   1424101_at (Mouse Genome 430 2.0 Array)   1445594_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134734
Ensembl peptide - ENSMUSP00000049407
Ensembl peptide - ENSMUSP00000133728
Ensembl peptide - ENSMUSP00000133932
Ensembl peptide - ENSMUSP00000133952
Ensembl peptide - ENSMUSP00000134271
NCBI entrez gene - 15388     See in Manteia.
MGI - MGI:104816
RefSeq - XM_006539560
RefSeq - NM_177301
RefSeq - XM_006539556
RefSeq - XM_006539557
RefSeq - XM_006539558
RefSeq - XM_006539559
RefSeq Peptide - NP_796275
swissprot - Q8R081
swissprot - G3UYY3
swissprot - G5E924
swissprot - G3UY56
swissprot - G3UY38
Ensembl - ENSMUSG00000015165
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hnrnplENSDARG00000035324Danio rerio
 hnrnpl2ENSDARG00000059303Danio rerio
 ENSGALG00000043929Gallus gallus
 HNRNPLENSG00000104824Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q921F4 / Hnrnpll / Heteroous nuclear ribonucleoprotein L-like / Q8WVV9* / heterogeneous nuclear ribonucleoprotein L like*ENSMUSG0000002409550
Ptbp1 / polypyrimidine tract binding protein 1 / P26599*ENSMUSG0000000649825
Ptbp3 / Q8BHD7 / Polypyrimidine tract-binding protein 3 / O95758*ENSMUSG0000002838224
Ptbp2 / Q91Z31 / Polypyrimidine tract-binding protein 2 / Q9UKA9*ENSMUSG0000002813423


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR006536  HnRNP-L/PTB
 IPR034816  hnRNP-L, RNA recognition motif 3
 IPR034817  hnRNP-L, RNA recognition motif 4
 IPR035005  hnRNP-L, RNA recognition motif 1
 IPR035008  hnRNP-L, RNA recognition motif 2
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000381 regulation of alternative mRNA splicing, via spliceosome ISO
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0034198 cellular response to amino acid starvation IEA
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0048025 negative regulation of mRNA splicing, via spliceosome IEA
 biological_processGO:1901652 response to peptide IEA
 biological_processGO:1902416 positive regulation of mRNA binding IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0035770 ribonucleoprotein granule ISS
 cellular_componentGO:0045120 pronucleus IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003730 mRNA 3"-UTR binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISS
 molecular_functionGO:0097157 pre-mRNA intronic binding ISS
 molecular_functionGO:1990715 mRNA CDS binding IEA


Pathways (from Reactome)
Pathway description
mRNA Splicing - Major Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Sec63tm1Som/Sec63tm1Som,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sec63tm1Som/Sec63tm1Som,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,Hnrnpltm1.1Tmo/Hnrnpltm1.1Tmo,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sec63tm1Som/Sec63tm1Som,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Sec63tm1Som/Sec63tm1Som,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Sec63tm1Som/Sec63tm1Som,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sec63tm1Som/Sec63tm1Som,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sec63tm1Som/Sec63tm1Som,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sec63tm1Som/Sec63tm1Som,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Sec63tm1Som/Sec63tm1Som,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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