ENSMUSG00000015605


Mus musculus

Features
Gene ID: ENSMUSG00000015605
  
Biological name :Srf
  
Synonyms : Q9JM73 / Serum response factor / Srf
  
Possible biological names infered from orthology : P11831
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: C
Gene start: 46546839
Gene end: 46556162
  
Corresponding Affymetrix probe sets: 10451363 (MoGene1.0st)   1418255_s_at (Mouse Genome 430 2.0 Array)   1418256_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000015749
NCBI entrez gene - 20807     See in Manteia.
MGI - MGI:106658
RefSeq - XM_011246336
RefSeq - NM_020493
RefSeq - XM_006523957
RefSeq Peptide - NP_065239
swissprot - Q9JM73
Ensembl - ENSMUSG00000015605
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 srfaENSDARG00000053918Danio rerio
 srfbENSDARG00000102867Danio rerio
 SRFENSGALG00000032029Gallus gallus
 SRFENSG00000112658Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002100  Transcription factor, MADS-box
 IPR033897  MADS SRF-like
 IPR036879  Transcription factor, MADS-box superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IMP
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001707 mesoderm formation IMP
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0001829 trophectodermal cell differentiation IEA
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0002011 morphogenesis of an epithelial sheet IMP
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis IEA
 biological_processGO:0002521 leukocyte differentiation IMP
 biological_processGO:0003257 positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007015 actin filament organization IMP
 biological_processGO:0007160 cell-matrix adhesion IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007369 gastrulation IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0007616 long-term memory IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008306 associative learning IMP
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0010669 epithelial structure maintenance IMP
 biological_processGO:0010735 positive regulation of transcription via serum response element binding IEA
 biological_processGO:0021766 hippocampus development IMP
 biological_processGO:0022028 tangential migration from the subventricular zone to the olfactory bulb IMP
 biological_processGO:0030036 actin cytoskeleton organization IMP
 biological_processGO:0030038 contractile actin filament bundle assembly IMP
 biological_processGO:0030155 regulation of cell adhesion IMP
 biological_processGO:0030168 platelet activation IMP
 biological_processGO:0030220 platelet formation IMP
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0030878 thyroid gland development IMP
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0031175 neuron projection development IMP
 biological_processGO:0033561 regulation of water loss via skin IMP
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0035855 megakaryocyte development IMP
 biological_processGO:0035912 dorsal aorta morphogenesis IMP
 biological_processGO:0042789 mRNA transcription by RNA polymerase II IDA
 biological_processGO:0043149 stress fiber assembly IMP
 biological_processGO:0043589 skin morphogenesis IMP
 biological_processGO:0045059 positive thymic T cell selection IMP
 biological_processGO:0045214 sarcomere organization IMP
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0045773 positive regulation of axon extension IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0045987 positive regulation of smooth muscle contraction IEA
 biological_processGO:0046016 positive regulation of transcription by glucose IEA
 biological_processGO:0046716 muscle cell cellular homeostasis IMP
 biological_processGO:0048538 thymus development IMP
 biological_processGO:0048589 developmental growth IMP
 biological_processGO:0048821 erythrocyte development IMP
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051491 positive regulation of filopodium assembly IMP
 biological_processGO:0055003 cardiac myofibril assembly IMP
 biological_processGO:0060218 hematopoietic stem cell differentiation IMP
 biological_processGO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter IEA
 biological_processGO:0060292 long term synaptic depression IMP
 biological_processGO:0060324 face development IMP
 biological_processGO:0060347 heart trabecula formation IMP
 biological_processGO:0060425 lung morphogenesis IMP
 biological_processGO:0060532 bronchus cartilage development IMP
 biological_processGO:0060534 trachea cartilage development IMP
 biological_processGO:0060947 cardiac vascular smooth muscle cell differentiation IMP
 biological_processGO:0061029 eyelid development in camera-type eye IMP
 biological_processGO:0061145 lung smooth muscle development IMP
 biological_processGO:0070830 bicellular tight junction assembly IMP
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0090009 primitive streak formation IMP
 biological_processGO:0090136 epithelial cell-cell adhesion IMP
 biological_processGO:0090398 cellular senescence IEA
 biological_processGO:0098609 cell-cell adhesion IMP
 biological_processGO:1900222 negative regulation of amyloid-beta clearance IEA
 biological_processGO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II IDA
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IDA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001076 transcription factor activity, RNA polymerase II transcription factor binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IGI
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0010736 serum response element binding IEA
 molecular_functionGO:0031490 chromatin DNA binding IDA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070878 primary miRNA binding IDA


Pathways (from Reactome)
Pathway description
RHO GTPases Activate Formins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Nrg1tm1Lwr/Nrg1+
Genetic Background: involves: 129/Sv

 MP:0000277 abnormal heart shape "malformation of the form or the patterning of the heart" [J:18048]
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Allelic Composition: Srftm1Zli/Srftm1Zli
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Srftm1Zli/Srftm1Zli
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Srftm1Rmn/Srftm1Rmn,Tg(Tagln-cre)1Jomm/0
Genetic Background: involves: CD-1

Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Srftm1Rjs/Srftm1Rjs
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000288 abnormal pericardium morphology "malformation of the fibroserous membrane covering the heart and beginning of the great vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:54408]
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Allelic Composition: Srftm1Rjs/Srftm1Rjs
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
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Allelic Composition: Srftm1Rjs/Srftm1Rjs
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
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Allelic Composition: Srftm1Zli/Srftm1Zli
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000460 mandible hypoplasia "arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J * SJL

 MP:0000705 athymia "absence of the primary lymphoid organ" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Srftm1Rmn/Srftm1Rmn,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0001404 no spontaneous movement "failure to make any change in position or posture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Nrg1tm1Lwr/Nrg1+
Genetic Background: involves: 129/Sv

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Nrg1tm1Lwr/Nrg1+
Genetic Background: involves: 129/Sv

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
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Allelic Composition: Srftm1Zli/Srftm1Zli
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
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Allelic Composition: Srftm1Rjs/Srftm1Rjs
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
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Allelic Composition: Srftm1Zli/Srftm1Zli
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
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Allelic Composition: Rps6tm1Om/Rps6tm1Om
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0001693 failure of primitive streak formation "inability to form the epiblast ridge from which arises the germ layers of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]
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Allelic Composition: Rps6tm1Om/Rps6tm1Om
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rps6tm1Om/Rps6tm1Om
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Srftm1Rjs/Srftm1Rjs
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Rps6tm1Om/Rps6tm1Om
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Srftm1Rjs/Srftm1Rjs
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nrg1tm1Lwr/Nrg1+
Genetic Background: involves: 129/Sv

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Nrg1tm1Lwr/Nrg1+
Genetic Background: involves: 129/Sv

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adcy3Jll/Adcy3Jll
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Srftm1Zli/Srftm1Zli
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Srftm1.1Wtp/Srftm1.1Wtp
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL * Swiss Webster

 MP:0002190 disorganized myocardium "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]
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Allelic Composition: Srftm1Zli/Srftm1Zli
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002279 abnormal diaphragm morphology "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nrg1tm1Lwr/Nrg1+
Genetic Background: involves: 129/Sv

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Srftm1Rmn/Srftm1Rmn,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Srftm1Zli/Srftm1Zli
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0002976 vascular smooth muscle hypotrophy "decrease in size or thickness of the smooth muscle of the vascular wall" [RGD:Rat Genome Database submission]
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Allelic Composition: Srftm1Rmn/Srftm1Rmn,Tg(Tagln-cre)1Jomm/0
Genetic Background: involves: CD-1

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nrg1tm1Lwr/Nrg1+
Genetic Background: involves: 129/Sv

Allelic Composition: Srftm2.1Nor/Srftm2.1Nor,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Srftm1Rjs/Srftm1Rjs
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Srftm1Zli/Srftm1Zli
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Srftm1Nor/Srftm1Nor
Genetic Background: involves: 129P2/OlaHsd

 MP:0004032 abnormal interventricular groove "malformation of the intendation dividing the two ventricles, comprised of the sulcus interventricularis anterior and the sulcus interventricularis posterior" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Srftm1Rjs/Srftm1Rjs
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004084 abnormal cardiac muscle relaxation "altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0004091 abnormal Z lines "any structural abnormality in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nrg1tm1Lwr/Nrg1+
Genetic Background: involves: 129/Sv

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Srftm2Nor/Srftm2Nor,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nrg1tm1Lwr/Nrg1+
Genetic Background: involves: 129/Sv

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Srftm1Rjs/Srftm1Rjs
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Srftm1Rjs/Srftm1Rjs
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005314 absent thyroid gland " missing endocrine gland that is normally located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30559]
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Allelic Composition: Srftm1Rmn/Srftm1Rmn,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Srftm1Rjs/Srftm1Rjs
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0006107 abnormal atrioventricular canal morphology "malformation or anomaly in development of the common canal connecting the primordial atrium and ventricle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93610]
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Allelic Composition: Srftm1Rjs/Srftm1Rjs
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0006267 abnormal intercalated disc morphology "any structural abnormality in the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:64280]
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Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0008022 dilated heart ventricles "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008171 abnormal mature B cell morphology "any structural anomaly of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Srftm2Nor/Srftm2Nor,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008183 absent marginal zone B cells "absence of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Srftm2Nor/Srftm2Nor,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Nrg1tm1Lwr/Nrg1+
Genetic Background: involves: 129/Sv

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Srftm1Rmn/Srftm1Rmn,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0010579 increased heart left ventricle size "greater than average size of the left ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0010725 thin interventricular septum "decreased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Srftm1Zli/Srftm1Zli
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Srftm2.1Nor/Srftm2.1Nor,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Nrg1tm1Lwr/Nrg1+
Genetic Background: involves: 129/Sv

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Srftm1Zli/Srftm1Zli
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Srftm1Rjs/Srftm1Rjs
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Srftm1Rmn/Srftm1Rmn,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Srftm1Rmn/Srftm1Rmn,Tg(Tagln-cre)1Jomm/0
Genetic Background: involves: CD-1

Allelic Composition: Srftm1Nor/Srftm1Nor
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Srftm1Rjs/Srftm2.1Nor,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000035236 Scai / Q8C8N2 / Protein SCAI / Q8N9R8* / suppressor of cancer cell invasion*  / complex / reaction
 ENSMUSG00000042292 Mkl1 / Q8K4J6 / MKL/myocardin-like protein 1 / Q969V6* / megakaryoblastic leukemia (translocation) 1*  / complex / reaction






 

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