ENSMUSG00000016024


Mus musculus

Features
Gene ID: ENSMUSG00000016024
  
Biological name :Lbp
  
Synonyms : Lbp / Lipopolysaccharide-binding protein / Q61805
  
Possible biological names infered from orthology : P18428
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H1
Gene start: 158306493
Gene end: 158332852
  
Corresponding Affymetrix probe sets: 10478048 (MoGene1.0st)   1447520_at (Mouse Genome 430 2.0 Array)   1448550_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105117
Ensembl peptide - ENSMUSP00000118297
Ensembl peptide - ENSMUSP00000016168
NCBI entrez gene - 16803     See in Manteia.
MGI - MGI:1098776
RefSeq - NM_008489
RefSeq Peptide - NP_032515
swissprot - Q61805
swissprot - A2AC65
swissprot - F6XKX9
Ensembl - ENSMUSG00000016024
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000006756Gallus gallus
 LBPENSG00000129988Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bpi / Q67E05 / Mus musculus bactericidal permeablility increasing protein (Bpi), transcript variant 2, mRNA. / P17213* / bactericidal/permeability-increasing protein*ENSMUSG0000005292238
Pltp / P55065 / phospholipid transfer protein / P55058*ENSMUSG0000001775425
Bpifc / BPI fold containing family C / Q8NFQ6*ENSMUSG0000005010822


Protein motifs (from Interpro)
Interpro ID Name
 IPR001124  Lipid-binding serum glycoprotein, C-terminal
 IPR017942  Lipid-binding serum glycoprotein, N-terminal
 IPR017943  Bactericidal permeability-increasing protein, alpha/beta domain superfamily
 IPR017954  Lipid-binding serum glycoprotein, conserved site
 IPR030180  Lipopolysaccharide-binding protein
 IPR030675  Lipid binding protein BPI/LBP
 IPR032942  BPI/LBP/Plunc family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002232 leukocyte chemotaxis involved in inflammatory response IMP
 biological_processGO:0002281 macrophage activation involved in immune response IDA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0006953 acute-phase response IEA
 biological_processGO:0008228 opsonization IC
 biological_processGO:0015920 lipopolysaccharide transport IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0032490 detection of molecule of bacterial origin IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IEA
 biological_processGO:0032722 positive regulation of chemokine production IMP
 biological_processGO:0032755 positive regulation of interleukin-6 production IEA
 biological_processGO:0032757 positive regulation of interleukin-8 production IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0033036 macromolecule localization IEA
 biological_processGO:0034145 positive regulation of toll-like receptor 4 signaling pathway IEA
 biological_processGO:0042535 positive regulation of tumor necrosis factor biosynthetic process IMP
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0043032 positive regulation of macrophage activation IEA
 biological_processGO:0044130 negative regulation of growth of symbiont in host IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045919 positive regulation of cytolysis IEA
 biological_processGO:0050829 defense response to Gram-negative bacterium IEA
 biological_processGO:0050830 defense response to Gram-positive bacterium IMP
 biological_processGO:0060265 positive regulation of respiratory burst involved in inflammatory response IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071223 cellular response to lipoteichoic acid IEA
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0001530 lipopolysaccharide binding IEA
 molecular_functionGO:0005102 signaling receptor binding IDA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0070891 lipoteichoic acid binding IEA
 molecular_functionGO:0071723 lipopeptide binding IEA


Pathways (from Reactome)
Pathway description
Toll Like Receptor 4 (TLR4) Cascade
Transfer of LPS from LBP carrier to CD14
Regulation of TLR by endogenous ligand


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pax6tm2Pgr/Pax6+,Tg(CAG-EGFP,-Pax6*5a,-lacZ)1Stoy/0,Tg(Dct-cre)1Apdn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abca5tm1Akya/Abca5tm1Akya
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * ICR

 MP:0002419 abnormal innate immunity "anomaly in the function of the early phase of the response to infection; normally, it is present at all times, does not increase with exposure to specific pathogens, and does not discriminate between pathogens" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0002498 abnormal acute inflammation "aberrant early and often transient reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0002723 abnormal immune serum protein physiology "abnormal concentration or function of circulating immune proteins" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6tm2Pgr/Pax6+,Tg(CAG-EGFP,-Pax6*5a,-lacZ)1Stoy/0,Tg(Dct-cre)1Apdn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003957 abnormal nitric oxide homeostasis "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stk4tm1.2Wtao/Stk4tm1.2Wtao
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pax6tm2Pgr/Pax6+,Tg(CAG-EGFP,-Pax6*5a,-lacZ)1Stoy/0,Tg(Dct-cre)1Apdn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stk4tm1.2Wtao/Stk4tm1.2Wtao
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

 MP:0008556 abnormal tumor necrosis factor secretion "anomaly in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Pax6tm2Pgr/Pax6+,Tg(CAG-EGFP,-Pax6*5a,-lacZ)1Stoy/0,Tg(Dct-cre)1Apdn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6tm2Pgr/Pax6+,Tg(CAG-EGFP,-Pax6*5a,-lacZ)1Stoy/0,Tg(Dct-cre)1Apdn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Lamb3tm1b(KOMP)Wtsi/Lamb3tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lamb3tm1b(KOMP)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000051439 Cd14 / P10810 / Monocyte differentiation antigen CD14 / P08571* / CD14 molecule*  / reaction






 

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