ENSMUSG00000017165


Mus musculus
increasedGaststomachcirculatinglevelcellgastrincholecystokininhormonereceptorsignalingpathwayactivityextracellularsignallingglucosedigestivesecretioninsulinincidencepeptideconservedsitesignaltransductiong-proteincoupledregulationresponsefoodregion

Features
Gene ID: ENSMUSG00000017165
  
Biological name :Gast
  
Synonyms : Gast / Gastrin Gastrin-71 Big gastrin Gastrin / P48757
  
Possible biological names infered from orthology : gastrin / P01350
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 100334407
Gene end: 100336996
  
Corresponding Affymetrix probe sets: 10381118 (MoGene1.0st)   1422915_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000017309
NCBI entrez gene - 14459     See in Manteia.
MGI - MGI:104768
RefSeq - NM_010257
RefSeq Peptide - NP_034387
swissprot - P48757
Ensembl - ENSMUSG00000017165
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GASTENSG00000184502Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001651  Gastrin/cholecystokinin peptide hormone
 IPR013152  Gastrin/cholecystokinin, conserved site


Gene Ontology (GO)
cell communicationcellular response to stimulusregulation of molecular functionresponse to external stimulusresponse to chemicalcell communicationcellular response to stimulusregulation of molecular functionresponse to external stimulusresponse to chemicalcell communicationcellular response to stimulusregulation of molecular functionresponse to external stimulusresponse to chemicalcell communicationcellular response to stimulusregulation of molecular functionresponse to external stimulusresponse to chemicalcell communicationcellular response to stimulusregulation of molecular functionresponse to external stimulusresponse to chemicalcell communicationcellular response to stimulusregulation of molecular functionresponse to external stimulusresponse to chemicalcell communicationcellular response to stimulusregulation of molecular functionresponse to external stimulusresponse to chemicalcell communicationcellular response to stimulusregulation of molecular functionresponse to external stimulusresponse to chemicalcell communicationcellular response to stimulusregulation of molecular functionresponse to external stimulusresponse to chemicalcell communicationcellular response to stimulusregulation of molecular functionresponse to external stimulusresponse to chemicalcell communicationcell communicationcellular response to stimulucellular response to stimulusregulation of molecular funcregulation of molecular functionresponse to external stimuluresponse to external stimulusresponse to chemicalresponse to chemical
protein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingprotein bindingreceptor regulator activityreceptor regulator activity
extracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0032094 response to food IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0005179 hormone activity IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPK


Phenotype (from MGI, Zfin or HPO)
homeostasis/metabolism phenotypedigestive/alimentary phenotypeimmune system phenotypeendocrine/exocrine gland phenotypetumorigenesishomeostasis/metabolism phenotypedigestive/alimentary phenotypeimmune system phenotypeendocrine/exocrine gland phenotypetumorigenesishomeostasis/metabolism phenotypedigestive/alimentary phenotypeimmune system phenotypeendocrine/exocrine gland phenotypetumorigenesishomeostasis/metabolism phenotypedigestive/alimentary phenotypeimmune system phenotypeendocrine/exocrine gland phenotypetumorigenesishomeostasis/metabolism phenotypedigestive/alimentary phenotypeimmune system phenotypeendocrine/exocrine gland phenotypetumorigenesishomeostasis/metabolism phenotypedigestive/alimentary phenotypeimmune system phenotypeendocrine/exocrine gland phenotypetumorigenesishomeostasis/metabolism phenotypedigestive/alimentary phenotypeimmune system phenotypeendocrine/exocrine gland phenotypetumorigenesishomeostasis/metabolism phenotypedigestive/alimentary phenotypeimmune system phenotypeendocrine/exocrine gland phenotypetumorigenesishomeostasis/metabolism phenotypedigestive/alimentary phenotypeimmune system phenotypeendocrine/exocrine gland phenotypetumorigenesishomeostasis/metabolism phenotypedigestive/alimentary phenotypeimmune system phenotypeendocrine/exocrine gland phenotypetumorigenesishomeostasis/metabolism phenohomeostasis/metabolism phenotypedigestive/alimentary phenotydigestive/alimentary phenotypeimmune system phenotypeimmune system phenotypeendocrine/exocrine gland pheendocrine/exocrine gland phenotypetumorigenesistumorigenesis
IDPhenotypeDefinition Genetic BG
 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pou4f2tm1Rsd/Pou4f2tm1Rsd
Genetic Background: involves: 129S4/SvJae

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gasttm1Tcw/Gasttm1Tcw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000501 abnormal digestive secretion "malfunction of the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from a cell or a gland of the digestive system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Gasttm1Tcw/Gasttm1Tcw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gasttm1Lcs/Gast+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gasttm1Tcw/Gasttm1Tcw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001873 stomach inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Gasttm1Tcw/Gasttm1Tcw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pou4f2tm1Rsd/Pou4f2tm1Rsd
Genetic Background: involves: 129S4/SvJae

 MP:0003564 abnormal insulin secretion "aberrant release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou4f2tm1Rsd/Pou4f2tm1Rsd
Genetic Background: involves: 129S4/SvJae

 MP:0003892 abnormal gastric gland "anomaly of any of the branched tubular glands in the mucosa of the fundus and body of the stomach that contain parietal cells that secrete hydrocholric acid and zymogenic cells that produce pepsin " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gasttm1Tcw/Gasttm1Tcw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Atp4btm1Ird/Atp4btm1Ird,Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cCrSlc

 MP:0004138 abnormal mucous neck cell morphology "malformation of the mucin-producing epithelial cells present in the the neck of the gastric glands " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gasttm1Tcw/Gasttm1Tcw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004139 abnormal parietal cell morphology "malformation of the gastric acid producing epithelial cells that are distributed throughout the length of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gasttm1Tcw/Gasttm1Tcw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Atp4btm1Ird/Atp4btm1Ird,Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cCrSlc

 MP:0004140 abnormal chief cell morphology "malformation of the pepsinogen producing epithelial cells that are clustered at the base of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gasttm1Tcw/Gasttm1Tcw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Atp4btm1Ird/Atp4btm1Ird,Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cCrSlc

 MP:0004151 hypoferremia "less than the normal concentration of this metallic element in the blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cckbrtm1Tom/Cckbr+
Genetic Background: B6.129S4-Cckbrtm1Tom

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pou4f2tm1Rsd/Pou4f2tm1Rsd
Genetic Background: involves: 129S4/SvJae

 MP:0005637 abnormal iron homeostasis "anomaly in the state of equilibrium in the body with respect to this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64456]
Show

Allelic Composition: Cckbrtm1Tom/Cckbr+
Genetic Background: B6.129S4-Cckbrtm1Tom

 MP:0008006 increased stomach pH "change in the function of the secretory and buffer systems of the stomach that control the relative acidity or alkalinity, such that the acidity is decreased, as indicated by the decreased concentration of hydrogen ion" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gasttm1Tcw/Gasttm1Tcw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010301 increased stomach tumor incidence "greater than the expected number of neoplasms in the gastric tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010792 abnormal stomach mucosa morphology "any structural anomaly of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gasttm1Tcw/Gasttm1Tcw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Atp4btm1Ird/Atp4btm1Ird,Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cCrSlc

 MP:0011896 increased circulating unsaturated transferrin level "increase in the concentration of transferrin that is not saturated (bound) with iron; this represents the reserve capacity of transferrin and is often measured by the Unsaturated Iron Binding Capacity (UIBC) test" [MGI:csmith]
Show

Allelic Composition: Cckbrtm1Tom/Cckbr+
Genetic Background: B6.129S4-Cckbrtm1Tom

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030898 Cckbr / P56481 / Gastrin/cholecystokinin type B receptor / P32239* / cholecystokinin B receptor*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   


© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr