ENSMUSG00000017195


Mus musculus

Features
Gene ID: ENSMUSG00000017195
  
Biological name :Zpbp2
  
Synonyms : Q6X786 / zona pellucida binding protein 2 / Zpbp2
  
Possible biological names infered from orthology : Q6X784
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 98551097
Gene end: 98558665
  
Corresponding Affymetrix probe sets: 10380944 (MoGene1.0st)   1429512_at (Mouse Genome 430 2.0 Array)   1460503_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000079822
Ensembl peptide - ENSMUSP00000103135
Ensembl peptide - ENSMUSP00000103137
Ensembl peptide - ENSMUSP00000017339
Ensembl peptide - ENSMUSP00000103133
NCBI entrez gene - 69376     See in Manteia.
MGI - MGI:1916626
RefSeq - NM_001166495
RefSeq - NM_001166494
RefSeq - NM_027061
RefSeq - NM_199419
RefSeq Peptide - NP_081337
RefSeq Peptide - NP_001159966
RefSeq Peptide - NP_001159967
RefSeq Peptide - NP_955451
swissprot - Q5FWC7
swissprot - A2A4X9
swissprot - Q6X786
Ensembl - ENSMUSG00000017195
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ZPBP2ENSGALG00000013484Gallus gallus
 ZPBP2ENSG00000186075Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Zpbp / zona pellucida binding protein / Q9BS86*ENSMUSG0000002019331


Protein motifs (from Interpro)
Interpro ID Name
 IPR010857  Zona-pellucida-binding
 IPR013783  Immunoglobulin-like fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001675 acrosome assembly IMP
 biological_processGO:0007339 binding of sperm to zona pellucida IDA
 cellular_componentGO:0001669 acrosomal vesicle IDA
 cellular_componentGO:0002199 zona pellucida receptor complex IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0044297 cell body IDA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Zpbptm1Zuk/Zpbp+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Hba-a1tm1Shs/Hba-a1+
Genetic Background: involves: C57BL/6CrSlc

Allelic Composition: Zpbptm1Zuk/Zpbp+,Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Zpbptm1Zuk/Zpbp+,Zpbp2tm1Zuk/Zpbp2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Zpbptm1Zuk/Zpbptm1Zuk,Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zpbptm1Zuk/Zpbptm1Zuk,Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002686 globozoospermia "malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Zpbptm1Zuk/Zpbptm1Zuk,Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zpbptm1Zuk/Zpbptm1Zuk,Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005411 delayed fertilization "a lag in the normal time of onset of the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hba-a1tm1Shs/Hba-a1+
Genetic Background: involves: C57BL/6CrSlc

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hba-a1tm1Shs/Hba-a1+
Genetic Background: involves: C57BL/6CrSlc

Allelic Composition: Zpbptm1Zuk/Zpbptm1Zuk,Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Zpbptm1Zuk/Zpbp+,Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Zpbptm1Zuk/Zpbp+,Zpbp2tm1Zuk/Zpbp2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zpbptm1Zuk/Zpbptm1Zuk,Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008839 absent acrosome "mature spermatozoa lack the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zpbptm1Zuk/Zpbptm1Zuk,Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
Show

Allelic Composition: Zpbptm1Zuk/Zpbptm1Zuk,Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008893 detached sperm flagellum "fragmentation of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility from the sperm head" [MESH:A05.360.490.890.840, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zpbptm1Zuk/Zpbptm1Zuk,Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008898 abnormal acrosome morphology "any structural anomaly of the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100]
Show

Allelic Composition: Zpbptm1Zuk/Zpbptm1Zuk,Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009232 abnormal sperm nucleus morphology "any structural abnormality of the sperm head nucleus, including an abnormal nuclear shape or defects in the compaction of nuclear chromatin" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zpbptm1Zuk/Zpbptm1Zuk,Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009238 coiled sperm flagellum "abnormal twisting of the sperm flagellum into coils or spirals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zpbptm1Zuk/Zpbptm1Zuk,Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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