ENSMUSG00000018286


Mus musculus

Features
Gene ID: ENSMUSG00000018286
  
Biological name :Psmb6
  
Synonyms : Proteasome subunit beta type-6 / Psmb6 / Q60692
  
Possible biological names infered from orthology : P28072 / proteasome subunit beta 6
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B3
Gene start: 70525367
Gene end: 70527858
  
Corresponding Affymetrix probe sets: 10377851 (MoGene1.0st)   1448822_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018430
NCBI entrez gene - 19175     See in Manteia.
MGI - MGI:104880
RefSeq - NM_008946
RefSeq Peptide - NP_032972
swissprot - Q60692
Ensembl - ENSMUSG00000018286
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psmb6ENSDARG00000002240Danio rerio
 PSMB6ENSG00000142507Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Psmb9 / proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) / P28065* / proteasome subunit beta 9*ENSMUSG0000009672755


Protein motifs (from Interpro)
Interpro ID Name
 IPR000243  Peptidase T1A, proteasome beta-subunit
 IPR001353  Proteasome, subunit alpha/beta
 IPR016050  Proteasome beta-type subunit, conserved site
 IPR023333  Proteasome B-type subunit
 IPR029055  Nucleophile aminohydrolases, N-terminal
 IPR035140  Proteasome subunit beta 6


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IEA
 cellular_componentGO:0000502 proteasome complex ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005839 proteasome core complex IDA
 cellular_componentGO:0019774 proteasome core complex, beta-subunit complex ISS
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004298 threonine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
AUF1 (hnRNP D0) binds and destabilizes mRNA
ABC-family proteins mediated transport
Antigen processing: Ubiquitination & Proteasome degradation
Activation of NF-kappaB in B cells
Asymmetric localization of PCP proteins
CDK-mediated phosphorylation and removal of Cdc6
CLEC7A (Dectin-1) signaling
Degradation of DVL
Degradation of GLI1 by the proteasome
Cross-presentation of soluble exogenous antigens (endosomes)
Degradation of beta-catenin by the destruction complex
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Downstream TCR signaling
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
Interleukin-1 signaling
MAPK6/MAPK4 signaling
Neddylation
Orc1 removal from chromatin
Regulation of PTEN stability and activity
Regulation of ornithine decarboxylase (ODC)
Regulation of RUNX2 expression and activity
Regulation of RAS by GAPs
SCF(Skp2)-mediated degradation of p27/p21
Regulation of RUNX3 expression and activity
TNFR2 non-canonical NF-kB pathway
Ub-specific processing proteases
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
UCH proteinases
Ubiquitin-dependent degradation of Cyclin D1
Separation of Sister Chromatids
NIK-->noncanonical NF-kB signaling
APC/C:Cdc20 mediated degradation of Securin
Autodegradation of the E3 ubiquitin ligase COP1
SCF-beta-TrCP mediated degradation of Emi1
Autodegradation of Cdh1 by Cdh1:APC/C
CDT1 association with the CDC6:ORC:origin complex
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
FCERI mediated NF-kB activation
Hedgehog ligand biogenesis
The role of GTSE1 in G2/M progression after G2 checkpoint
G2/M Checkpoints
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Dectin-1 mediated noncanonical NF-kB signaling
Degradation of AXIN
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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