ENSMUSG00000018893


Mus musculus

Features
Gene ID: ENSMUSG00000018893
  
Biological name :Mb
  
Synonyms : Mb / myoglobin / P04247
  
Possible biological names infered from orthology : P02144
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: D3
Gene start: 77015487
Gene end: 77050670
  
Corresponding Affymetrix probe sets: 10430140 (MoGene1.0st)   1422420_at (Mouse Genome 430 2.0 Array)   1451203_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000155252
Ensembl peptide - ENSMUSP00000019037
Ensembl peptide - ENSMUSP00000125995
Ensembl peptide - ENSMUSP00000128399
Ensembl peptide - ENSMUSP00000154870
Ensembl peptide - ENSMUSP00000155115
NCBI entrez gene - 17189     See in Manteia.
MGI - MGI:96922
RefSeq - NM_001164047
RefSeq - NM_001164048
RefSeq - NM_013593
RefSeq Peptide - NP_001157519
RefSeq Peptide - NP_001157520
RefSeq Peptide - NP_038621
swissprot - P04247
swissprot - Q3UVB1
Ensembl - ENSMUSG00000018893
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mbENSDARG00000031952Danio rerio
 MBENSGALG00000012541Gallus gallus
 MBENSG00000198125Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cygb / Q9CX80 / Cytoglobin / Q8WWM9*ENSMUSG0000002081027


Protein motifs (from Interpro)
Interpro ID Name
 IPR000971  Globin
 IPR002335  Myoglobin
 IPR009050  Globin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0015671 oxygen transport IEA
 biological_processGO:0031444 slow-twitch skeletal muscle fiber contraction IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0043353 enucleate erythrocyte differentiation IMP
 biological_processGO:0050873 brown fat cell differentiation IDA
 molecular_functionGO:0005344 oxygen carrier activity IEA
 molecular_functionGO:0019825 oxygen binding IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Intracellular oxygen transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

 MP:0001574 abnormal oxygen level "anomalous concentration of this gaseous element, essential for animal and plant life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdx1tm1Ted/Pdx1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mbtm1Wlm/Mbtm1Wlm
Genetic Background: either: (involves: 129/Sv) or (involves: C57BL/6)

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Pdx1tm1Ted/Pdx1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Mbtm1Wlm/Mb+
Genetic Background: either: (involves: 129/Sv) or (involves: C57BL/6)

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Pdx1tm1Ted/Pdx1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pdx1tm1Ted/Pdx1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Mbtm1Wlm/Mb+
Genetic Background: either: (involves: 129/Sv) or (involves: C57BL/6)

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Mbtm1Wlm/Mb+
Genetic Background: either: (involves: 129/Sv) or (involves: C57BL/6)

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pdx1tm1Ted/Pdx1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003022 increased coronary flow rate "elevated rate of blood flow in the blood vessels supplying the heart" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

 MP:0003081 abnormal soleus morphology "anomaly in the the superficial flat broad muscle of the calf that is responsible for plantar flexion of the foot" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp)c35Cwe/0
Genetic Background: Not Specified

 MP:0003646 muscle fatigue "increased muscle exhaustion or increased susceptibility to muscle exhaustion" [J:96306]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp)c35Cwe/0
Genetic Background: Not Specified

 MP:0003957 abnormal nitric oxide homeostasis "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mbtm1Wlm/Mbtm1Wlm
Genetic Background: B6.Cg-Mbtm1Wlm

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mbtm1Wlm/Mbtm1Wlm
Genetic Background: either: (involves: 129/Sv) or (involves: C57BL/6)

Allelic Composition: Mbtm1Wlm/Mb+
Genetic Background: either: (involves: 129/Sv) or (involves: C57BL/6)

 MP:0005039 hypoxia "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp)c35Cwe/0
Genetic Background: Not Specified

Allelic Composition: Mbtm1Wlm/Mbtm1Wlm
Genetic Background: either: (involves: 129/Sv) or (involves: C57BL/6)

Allelic Composition: Mbtm1Wlm/Mbtm1Wlm
Genetic Background: B6.Cg-Mbtm1Wlm

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp)c35Cwe/0
Genetic Background: Not Specified

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mbtm1Wlm/Mbtm1Wlm
Genetic Background: either: (involves: 129/Sv) or (involves: C57BL/6)

Allelic Composition: Mbtm1Wlm/Mb+
Genetic Background: either: (involves: 129/Sv) or (involves: C57BL/6)

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp)c35Cwe/0
Genetic Background: Not Specified

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Mbtm1Wlm/Mbtm1Wlm
Genetic Background: B6.Cg-Mbtm1Wlm

 MP:0005601 increased angiogenesis "enhanced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp)c35Cwe/0
Genetic Background: Not Specified

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mbtm1Wlm/Mbtm1Wlm
Genetic Background: either: (involves: 129/Sv) or (involves: C57BL/6)

Allelic Composition: Mbtm1Wlm/Mb+
Genetic Background: either: (involves: 129/Sv) or (involves: C57BL/6)

 MP:0008788 abnormal fetal cardiomyocyte morphology "any structural anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [PMID:17429040]
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Allelic Composition: Mbtm1Wlm/Mbtm1Wlm
Genetic Background: either: (involves: 129/Sv) or (involves: C57BL/6)

 MP:0009409 abnormal skeletal muscle fiber type ratio "deviation from the standard ratios of fiber types in a given skeletal muscle compared to control samples" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp)c35Cwe/0
Genetic Background: Not Specified

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Mbtm1Wlm/Mbtm1Wlm
Genetic Background: either: (involves: 129/Sv) or (involves: C57BL/6)

Allelic Composition: Mbtm1Wlm/Mb+
Genetic Background: either: (involves: 129/Sv) or (involves: C57BL/6)

 MP:0020330 increased capillary density "increase in the number of capillaries in a given cross-sectional area of a tissue" [ORCID: orcid.org/0000-0003-4606-0597, PMID:20705734]
Show

Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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