ENSMUSG00000019936


Mus musculus
leucine-richrepeatEpycdomainextracellulardecreasedn-terminaltypicalsubtypeepiphycansuperfamilyaxonogenesisregionspaceproteinbindingbodyweightshortfemurosteoarthritisosteophytescollagenlevel

Features
Gene ID: ENSMUSG00000019936
  
Biological name :Epyc
  
Synonyms : Epiphycan / Epyc / P70186
  
Possible biological names infered from orthology : Q99645
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C3
Gene start: 97644068
Gene end: 97682454
  
Corresponding Affymetrix probe sets: 10365991 (MoGene1.0st)   1421114_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020094
Ensembl peptide - ENSMUSP00000100922
NCBI entrez gene - 13516     See in Manteia.
MGI - MGI:107942
RefSeq - NM_007884
RefSeq Peptide - NP_031910
swissprot - P70186
Ensembl - ENSMUSG00000019936
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 epycENSDARG00000056950Danio rerio
 EPYCENSGALG00000011269Gallus gallus
 EPYCENSG00000083782Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Optc / opticin isoform 4 / Q9UBM4* / opticin*ENSMUSG0000001031141
Ogn / Q62000 / osteoglycin / P20774*ENSMUSG0000002139034


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR027217  Epiphycan
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
cellular component organizationanatomical structure developmentcellular developmental processcellular component organizationanatomical structure developmentcellular developmental processcellular component organizationanatomical structure developmentcellular developmental processcellular component organizationanatomical structure developmentcellular developmental processcellular component organizationanatomical structure developmentcellular developmental processcellular component organizationanatomical structure developmentcellular developmental processcellular component organizationanatomical structure developmentcellular developmental processcellular component organizationanatomical structure developmentcellular developmental processcellular component organizationanatomical structure developmentcellular developmental processcellular component organizationanatomical structure developmentcellular developmental processcellular component organizationcellular component organizationanatomical structure developmentanatomical structure developmentcellular developmental processcellular developmental process
protein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein binding
extracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0007409 axonogenesis IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
growth/size phenotypeskeleton phenotypelimbs/digits/tail phenotypeimmune system phenotypehomeostasis/metabolism phenotypegrowth/size phenotypeskeleton phenotypelimbs/digits/tail phenotypeimmune system phenotypehomeostasis/metabolism phenotypegrowth/size phenotypeskeleton phenotypelimbs/digits/tail phenotypeimmune system phenotypehomeostasis/metabolism phenotypegrowth/size phenotypeskeleton phenotypelimbs/digits/tail phenotypeimmune system phenotypehomeostasis/metabolism phenotypegrowth/size phenotypeskeleton phenotypelimbs/digits/tail phenotypeimmune system phenotypehomeostasis/metabolism phenotypegrowth/size phenotypeskeleton phenotypelimbs/digits/tail phenotypeimmune system phenotypehomeostasis/metabolism phenotypegrowth/size phenotypeskeleton phenotypelimbs/digits/tail phenotypeimmune system phenotypehomeostasis/metabolism phenotypegrowth/size phenotypeskeleton phenotypelimbs/digits/tail phenotypeimmune system phenotypehomeostasis/metabolism phenotypegrowth/size phenotypeskeleton phenotypelimbs/digits/tail phenotypeimmune system phenotypehomeostasis/metabolism phenotypegrowth/size phenotypeskeleton phenotypelimbs/digits/tail phenotypeimmune system phenotypehomeostasis/metabolism phenotypegrowth/size phenotypegrowth/size phenotypeskeleton phenotypeskeleton phenotypelimbs/digits/tail phenotypelimbs/digits/tail phenotypeimmune system phenotypeimmune system phenotypehomeostasis/metabolism phenohomeostasis/metabolism phenotype
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Epyctm1Mhok/Epyctm1Mhok
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0003560 osteoarthritis "a type of arthritis that is caused by the breakdown and eventual loss of the cartilage of one or more joints" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95374]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Epyctm1Mhok/Epyctm1Mhok
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0013304 osteophytes "bony projections that form along joint margins at bone edges, including the spine; these are frequently found in areas affected by arthritis such as the disc or joint spaces where cartilage has deteriorated" [MGI:mlaw]
Show

Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Epyctm1Mhok/Epyctm1Mhok
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0020254 decreased collagen level "decreased level of the main structural protein of the various connective tissues in animals" [GOC:NV, PMID:11704682]
Show

Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Epyctm1Mhok/Epyctm1Mhok
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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