ENSMUSG00000020087


Mus musculus

Features
Gene ID: ENSMUSG00000020087
  
Biological name :Tysnd1
  
Synonyms : Q9DBA6 / trypsin domain containing 1 / Tysnd1
  
Possible biological names infered from orthology : Q2T9J0
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B4
Gene start: 61695514
Gene end: 61702773
  
Corresponding Affymetrix probe sets: 10363522 (MoGene1.0st)   1428689_at (Mouse Genome 430 2.0 Array)   1428690_at (Mouse Genome 430 2.0 Array)   1441856_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151532
Ensembl peptide - ENSMUSP00000151548
Ensembl peptide - ENSMUSP00000020284
Ensembl peptide - ENSMUSP00000151511
NCBI entrez gene - 71767     See in Manteia.
MGI - MGI:1919017
RefSeq - NM_001272090
RefSeq - NM_001272091
RefSeq - NM_001272092
RefSeq - NM_027912
RefSeq Peptide - NP_001259021
RefSeq Peptide - NP_082188
RefSeq Peptide - NP_001259019
RefSeq Peptide - NP_001259020
swissprot - A0A1W2P741
swissprot - A0A1W2P7A9
swissprot - Q9DBA6
swissprot - A0A1W2P754
Ensembl - ENSMUSG00000020087
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tysnd1ENSDARG00000074895Danio rerio
 TYSND1ENSGALG00000033807Gallus gallus
 Q2T9J0ENSG00000156521Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009003  Peptidase S1, PA clan
 IPR017345  Peptidase S1A, Tysnd1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis ISO
 biological_processGO:0016485 protein processing IEA
 biological_processGO:0031998 regulation of fatty acid beta-oxidation IEA
 biological_processGO:0051260 protein homooligomerization IEA
 cellular_componentGO:0005777 peroxisome IBA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
Peroxisomal protein import
TYSND1 cleaves peroxisomal proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002686 globozoospermia "malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008898 abnormal acrosome morphology "any structural anomaly of the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100]
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Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009647 decreased fertilization frequency "he number of secondary oocytes each penetrated by a spermatozoon followed by fusion of the male and female pronuclei are fewer than expected" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009832 abnormal sperm mitochondrial sheath morphology "any structural anomaly or impairment of the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum" [PMID:14581499]
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Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009838 abnormal sperm axoneme morphology "any structural abnormality of the central core of the sperm flagellum, composed of a ring of 9 outer microtubule doublets surrounding a central pair; inner and outer dynein arms project from each of the outer 9 doublets, and these arms are responsible for generating the motive force of the flagellum; in addition, 9 radial spokes, each of which originates from 1 of the 9 outer microtubular doublet pairs, project inward toward the central pair in a helical fashion" [PMID:14581499]
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Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011971 increased circulating lactate dehydrogenase level "elevated blood level of the tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of lactate and pyruvate; measurements of circulating levels are used clinically as a diagnostic indicator of tissue breakdown, some forms of cancer or particular infection types" [MeSH:D08.811.682.047.551.400, MGI:csmith]
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Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0012216 decreased plasmalogen level "reduction in the amount of the glycerophospholipid class of lipids that contain a vinyl ether moiety at the sn-1-position of the glycerol backbone and are and enriched in polyunsaturated fatty acids at the sn-2 position of the glycerol backbone" [PMID:19519379, PMID:22627108]
Show

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024507 P51660 / Hsd17b4 / hydroxysteroid (17-beta) dehydrogenase 4 / P51659*  / reaction
 ENSMUSG00000026664 Phyh / O35386 / phytanoyl-CoA hydroxylase / O14832* / phytanoyl-CoA 2-hydroxylase*  / reaction
 ENSMUSG00000036138 Acaa1a / Q921H8 / acetyl-Coenzyme A acyltransferase 1A / ACAA1* / P09110* / acetyl-CoA acyltransferase 1*  / reaction
 ENSMUSG00000028603 Scp2 / P32020 / sterol carrier protein 2, liver / P22307* / sterol carrier protein 2*  / reaction






 

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