ENSMUSG00000020166


Mus musculus
regulationCnot2transcriptionrnacellmembranepolymeraseiimrnadna-templatedtranslationpathwayccr-notcomplexnuclear-transcribedcatabolicprocessdeadenylation-dependentdecaytrophectodermaldifferentiationmulticellularorganismdevelopmentcytoplasmicprocessingbodyassemblygenesilencing

Features
Gene ID: ENSMUSG00000020166
  
Biological name :Cnot2
  
Synonyms : Cnot2 / Mus musculus CCR4-NOT transcription complex, subunit 2 (Cnot2), transcript variant 6, mRNA. / Q8C5L3
  
Possible biological names infered from orthology : CCR4-NOT transcription complex subunit 2 / Q9NZN8
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D2
Gene start: 116485161
Gene end: 116581511
  
Corresponding Affymetrix probe sets: 10372534 (MoGene1.0st)   1436980_x_at (Mouse Genome 430 2.0 Array)   1445017_at (Mouse Genome 430 2.0 Array)   1447212_at (Mouse Genome 430 2.0 Array)   1454602_s_at (Mouse Genome 430 2.0 Array)   1454603_a_at (Mouse Genome 430 2.0 Array)   1456576_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130192
Ensembl peptide - ENSMUSP00000128837
Ensembl peptide - ENSMUSP00000132152
Ensembl peptide - ENSMUSP00000151847
Ensembl peptide - ENSMUSP00000151501
Ensembl peptide - ENSMUSP00000132315
Ensembl peptide - ENSMUSP00000020374
Ensembl peptide - ENSMUSP00000100900
Ensembl peptide - ENSMUSP00000100902
Ensembl peptide - ENSMUSP00000127830
Ensembl peptide - ENSMUSP00000128720
NCBI entrez gene - 72068     See in Manteia.
MGI - MGI:1919318
RefSeq - XM_017314113
RefSeq - XM_006514179
RefSeq - XM_006514180
RefSeq - XM_006514181
RefSeq - XM_006514182
RefSeq - XM_006514183
RefSeq - XM_006514184
RefSeq - XM_006514186
RefSeq - XM_006514188
RefSeq - XM_006514189
RefSeq - XM_006514190
RefSeq - XM_006514191
RefSeq - XM_017314106
RefSeq - XM_017314107
RefSeq - XM_017314108
RefSeq - XM_017314109
RefSeq - XM_017314111
RefSeq - XM_017314112
RefSeq - NM_001037846
RefSeq - NM_001037847
RefSeq - NM_001037848
RefSeq - NM_001359247
RefSeq - NM_001359248
RefSeq - NM_001359249
RefSeq - NM_001359250
RefSeq - NM_001359251
RefSeq - NM_001359252
RefSeq - NM_028082
RefSeq - XM_006514174
RefSeq - XM_006514175
RefSeq - XM_006514177
RefSeq Peptide - NP_001032936
RefSeq Peptide - NP_001346177
RefSeq Peptide - NP_001346178
RefSeq Peptide - NP_001346179
RefSeq Peptide - NP_001346180
RefSeq Peptide - NP_001346181
RefSeq Peptide - NP_082358
RefSeq Peptide - NP_001032935
RefSeq Peptide - NP_001032937
RefSeq Peptide - NP_001346176
swissprot - E9Q8D5
swissprot - E9Q7M5
swissprot - H7BWX6
swissprot - E9Q027
swissprot - A0A1W2P771
swissprot - E9Q8R6
swissprot - Q8C5L3
Ensembl - ENSMUSG00000020166
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cnot2ENSDARG00000061802Danio rerio
 CNOT2ENSGALG00000010042Gallus gallus
 CNOT2ENSG00000111596Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007282  NOT2/NOT3/NOT5


Gene Ontology (GO)
nitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcatabolic processanatomical structure developmentcellular developmental processcellular component organizationcellular component biogenesiscell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcatabolic processanatomical structure developmentcellular developmental processcellular component organizationcellular component biogenesiscell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcatabolic processanatomical structure developmentcellular developmental processcellular component organizationcellular component biogenesiscell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcatabolic processanatomical structure developmentcellular developmental processcellular component organizationcellular component biogenesiscell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcatabolic processanatomical structure developmentcellular developmental processcellular component organizationcellular component biogenesiscell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcatabolic processanatomical structure developmentcellular developmental processcellular component organizationcellular component biogenesiscell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcatabolic processanatomical structure developmentcellular developmental processcellular component organizationcellular component biogenesiscell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcatabolic processanatomical structure developmentcellular developmental processcellular component organizationcellular component biogenesiscell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcatabolic processanatomical structure developmentcellular developmental processcellular component organizationcellular component biogenesiscell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcatabolic processanatomical structure developmentcellular developmental processcellular component organizationcellular component biogenesiscell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusmaintenance of cell numbernitrogen nitrogen compound metabolic processbiosynthebiosynthetic processcellular cellular metabolic processprimary mprimary metabolic processorganic sorganic substance metabolic processcataboliccatabolic processanatomicaanatomical structure developmentcellular cellular developmental processcellular cellular component organizationcellular cellular component biogenesiscell commcell communicationresponse response to endogenous stimulusresponse response to chemicalcellular cellular response to stimulusmaintenanmaintenance of cell number
protein bindinghydrolase activitycatalytic activity, acting on RNAprotein bindinghydrolase activitycatalytic activity, acting on RNAprotein bindinghydrolase activitycatalytic activity, acting on RNAprotein bindinghydrolase activitycatalytic activity, acting on RNAprotein bindinghydrolase activitycatalytic activity, acting on RNAprotein bindinghydrolase activitycatalytic activity, acting on RNAprotein bindinghydrolase activitycatalytic activity, acting on RNAprotein bindinghydrolase activitycatalytic activity, acting on RNAprotein bindinghydrolase activitycatalytic activity, acting on RNAprotein bindinghydrolase activitycatalytic activity, acting on RNAprotein bindingprotein bindinghydrolase activityhydrolase activitycatalytic activity, acting on RNAcatalytic activity, acting on RNA
cellprotein-containing complexorganellemembranecellprotein-containing complexorganellemembranecellprotein-containing complexorganellemembranecellprotein-containing complexorganellemembranecellprotein-containing complexorganellemembranecellprotein-containing complexorganellemembranecellprotein-containing complexorganellemembranecellprotein-containing complexorganellemembranecellprotein-containing complexorganellemembranecellprotein-containing complexorganellemembranecellcellprotein-containing complexprotein-containing complexorganelleorganellemembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
 biological_processGO:0001829 trophectodermal cell differentiation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010606 positive regulation of cytoplasmic mRNA processing body assembly ISO
 biological_processGO:0017148 negative regulation of translation IBA
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0033147 negative regulation of intracellular estrogen receptor signaling pathway ISS
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 biological_processGO:2000036 regulation of stem cell population maintenance IMP
 cellular_componentGO:0000932 P-body IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030014 CCR4-NOT complex ISO
 cellular_componentGO:0030015 CCR4-NOT core complex IBA
 molecular_functionGO:0001226 RNA polymerase II transcription corepressor binding ISO
 molecular_functionGO:0004535 poly(A)-specific ribonuclease activity ISO


Pathways (from Reactome)
Pathway description
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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