ENSMUSG00000020300


Mus musculus

Features
Gene ID: ENSMUSG00000020300
  
Biological name :Cpeb4
  
Synonyms : Cpeb4 / Cytoplasmic polyadenylation element-binding protein 4 / Q7TN98
  
Possible biological names infered from orthology : Q17RY0
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A4
Gene start: 31872211
Gene end: 31935634
  
Corresponding Affymetrix probe sets: 10375002 (MoGene1.0st)   1420617_at (Mouse Genome 430 2.0 Array)   1420618_at (Mouse Genome 430 2.0 Array)   1449931_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020543
Ensembl peptide - ENSMUSP00000105039
Ensembl peptide - ENSMUSP00000116753
NCBI entrez gene - 67579     See in Manteia.
MGI - MGI:1914829
RefSeq - XM_006514793
RefSeq - NM_001290676
RefSeq - NM_001290678
RefSeq - NM_026252
RefSeq Peptide - NP_001277607
RefSeq Peptide - NP_080528
RefSeq Peptide - NP_001277605
swissprot - Q5SU47
swissprot - Q5SU48
swissprot - Q7TN98
Ensembl - ENSMUSG00000020300
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cpeb4aENSDARG00000056691Danio rerio
 cpeb4bENSDARG00000100499Danio rerio
 CPEB4ENSGALG00000033512Gallus gallus
 CPEB4ENSG00000113742Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cpeb3 / Q7TN99 / Cytoplasmic polyadenylation element-binding protein 3 / Q8NE35*ENSMUSG0000003965259
Cpeb2 / cytoplasmic polyadenylation element-binding protein 2 isoform 1 / Q7Z5Q1* / cytoplasmic polyadenylation element binding protein 2*ENSMUSG0000003978257
Cpeb1 / P70166 / Mus musculus cytoplasmic polyadenylation element binding protein 1 (Cpeb1), transcript variant 4, mRNA. / RPS17* / P08708* / Q9BZB8* / AC245033.1* / ribosomal protein S17* ...ENSMUSG0000002558624


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR032296  Cytoplasmic polyadenylation element-binding protein, ZZ domain
 IPR034819  Cytoplasmic polyadenylation element-binding protein
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002931 response to ischemia IDA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0035235 ionotropic glutamate receptor signaling pathway ISS
 biological_processGO:0036294 cellular response to decreased oxygen levels ISS
 biological_processGO:0042149 cellular response to glucose starvation ISS
 biological_processGO:0043524 negative regulation of neuron apoptotic process ISS
 biological_processGO:0071230 cellular response to amino acid stimulus ISS
 biological_processGO:2000766 negative regulation of cytoplasmic translation IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:1990124 messenger ribonucleoprotein complex IBA
 molecular_functionGO:0000900 translation repressor activity, mRNA regulatory element binding IBA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IDA
 molecular_functionGO:0003730 mRNA 3"-UTR binding IBA
 molecular_functionGO:0008135 translation factor activity, RNA binding IBA
 molecular_functionGO:0043022 ribosome binding IBA
 molecular_functionGO:0045182 translation regulator activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5tm3.1Mwc
Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
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Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5tm3.1Mwc
Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5tm3.1Mwc
Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5tm3.1Mwc
Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5tm3.1Mwc
Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5tm3.1Mwc
Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5tm3.1Mwc
Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
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Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5tm3.1Mwc
Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc

 MP:0003795 abnormal bone structure 
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Allelic Composition: Cisd2tm1a(EUCOMM)Wtsi/Cisd2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cisd2tm1a(EUCOMM)Wtsi/H

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5tm3.1Mwc
Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc

 MP:0008415 abnormal neurite morphology "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
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Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5tm3.1Mwc
Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5tm3.1Mwc
Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5tm3.1Mwc
Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Pkd1tm2Ggg/Pkd1tm2Ggg,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5tm3.1Mwc
Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5tm3.1Mwc
Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc

 MP:0011112 partial lethality during fetal growth through weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5tm3.1Mwc
Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc

 MP:0011240 abnormal fetal derived definitive erythrocyte morphology "any structural anomaly of a fetal liver derived enucleated erythrocyte, which matures in macrophage islands within the liver, enucleates, and then enters the bloodstream; these resemble adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemoglobins" [CL:0002357, PMID:18282515]
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Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5tm3.1Mwc
Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc

 MP:0011243 decreased fetal derived definitive erythrocyte cell number "reduced number of fetal liver derived enucleated erythrocytes, which mature in macrophage islands within the liver, enucleate, and then enter the bloodstream; these resemble adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemoglobins" [CL:0002357, PMID:18282515]
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Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5tm3.1Mwc
Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc

 MP:0012055 abnormal phrenic nerve innervation pattern to diaphragm "any changes in the placement, morphology or number of the portion of phrenic nerve fibers providing motor supply to the diaphragm" [MGI:csmith]
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Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5tm3.1Mwc
Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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