ENSMUSG00000020319


Mus musculus

Features
Gene ID: ENSMUSG00000020319
  
Biological name :Wdpcp
  
Synonyms : Q8C456 / Wdpcp / WD repeat containing planar cell polarity effector
  
Possible biological names infered from orthology : O95876
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A3.1
Gene start: 21572235
Gene end: 21898989
  
Corresponding Affymetrix probe sets: 10374529 (MoGene1.0st)   1426280_at (Mouse Genome 430 2.0 Array)   1441470_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120122
Ensembl peptide - ENSMUSP00000020568
NCBI entrez gene - 216560     See in Manteia.
MGI - MGI:2144467
RefSeq - XM_017314435
RefSeq - XM_006514639
RefSeq - XM_006514641
RefSeq - XM_011243680
RefSeq - XM_017314434
RefSeq - NM_145425
RefSeq - XM_006514631
RefSeq - XM_006514632
RefSeq - XM_006514635
RefSeq - XM_006514636
RefSeq - XM_006514637
RefSeq - XM_006514638
RefSeq Peptide - NP_663400
swissprot - B1ATQ4
swissprot - B1ATJ7
swissprot - Q8C456
Ensembl - ENSMUSG00000020319
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wdpcpENSDARG00000074590Danio rerio
 WDPCPENSGALG00000008866Gallus gallus
 WDPCPENSG00000143951Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR024511  WD repeat-containing and planar cell polarity effector protein Fritz
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0002093 auditory receptor cell morphogenesis IMP
 biological_processGO:0007224 smoothened signaling pathway IMP
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0010762 regulation of fibroblast migration IMP
 biological_processGO:0016476 regulation of embryonic cell shape ISS
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0032185 septin cytoskeleton organization ISS
 biological_processGO:0032880 regulation of protein localization ISS
 biological_processGO:0042733 embryonic digit morphogenesis IMP
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0044782 cilium organization IMP
 biological_processGO:0045184 establishment of protein localization IMP
 biological_processGO:0048568 embryonic organ development IGI
 biological_processGO:0051893 regulation of focal adhesion assembly IMP
 biological_processGO:0055123 digestive system development IMP
 biological_processGO:0060021 roof of mouth development IMP
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:0060541 respiratory system development IMP
 biological_processGO:0072358 cardiovascular system development IMP
 biological_processGO:0090521 glomerular visceral epithelial cell migration IMP
 biological_processGO:1900027 regulation of ruffle assembly IMP
 biological_processGO:2000114 regulation of establishment of cell polarity IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0005930 axoneme ISS
 cellular_componentGO:0005938 cell cortex ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0097541 axonemal basal plate IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Wdpcptm1.1Clo/Wdpcptm1.1Clo
Genetic Background: involves: 129

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Wdpcptm1.1Clo/Wdpcptm1.1Clo
Genetic Background: involves: 129

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Wdpcptm1.1Clo/Wdpcptm1.1Clo
Genetic Background: involves: 129

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
Show

Allelic Composition: Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Wdpcptm1.1Clo/Wdpcptm1.1Clo
Genetic Background: involves: 129

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Ptch1tm1Mps/Ptch1tm1Mps,Wdpcpcys40/Wdpcpcys40
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002622 abnormal cochlear hair cell morphology "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003125 abnormal septation of the cloaca "absence of or reduction in the separation of the single opening of the digestive, urinary, and reproductive tracts (cloaca) into mutliple isolated openings during development, may result in hypospadia, reduced anogenital distance, or persistent cloaca" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91491]
Show

Allelic Composition: Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003321 tracheoesophageal fistula "an abnormal passage between the esophagus and the trachea, acquired or congenital, often associated with esophageal atresia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Wdpcptm1.1Clo/Wdpcptm1.1Clo
Genetic Background: involves: 129

 MP:0004017 duplex kidney "a kidney that is split into two separate collecting systems; there may be a duplex ureter or a single ureter; may present unilaterally or bilaterally" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Wdpcptm1.1Clo/Wdpcptm1.1Clo
Genetic Background: involves: 129

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004754 abnormal kidney collecting duct "any structural anomaly of the duct that drains fluid from the nephron and either allows bodily reabsorbtion of water or allows the fluid to drain to the bladder via the ureter; the collecting duct system also maintains acid-base homeostasis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Wdpcptm1.1Clo/Wdpcptm1.1Clo
Genetic Background: involves: 129

 MP:0006130 pulmonary valve atresia "congenital closure of the pulmonary valve" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008797 facial cleft "a cleft resulting from incomplete merging or fusion of any of the embryonic facial processes that normally unite to form the face" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0010412 atrioventricular septal defect "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
Show

Allelic Composition: Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0010454 abnormal truncus arteriosis septation "anomaly in the process of dividing the common arterial trunk arising out of both heart ventricles to divide into the aorta and pulmonary artery during development" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011060 abnormal kinocilium morphology "any structural anomaly of the nonmotile primary cilium that is found at the apical surface of auditory receptor cells" [GO:0060091]
Show

Allelic Composition: Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Wdpcptm1.1Clo/Wdpcptm1.1Clo
Genetic Background: involves: 129

 MP:0011682 renal glomerulus cysts "abnormal membranous sacs in any portion of the renal glomerulus" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011707 impaired fibroblast cell migration "failure of cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011865 abnormal podocyte motility "any anomaly in the ability of podocyte foot processes (FPs) to retract or elongate and hence move quickly along the glomerular basement membrane (GBM); motility refers to the dynamic reorganization of the interdigitating FP structure in vivo , and to the cell migration of cultured podocytes in vitro that is seen as surrogate for the former; alterations in podocyte motility are considered to underlie foot process effacement, with changes in the leading edge of the cell and its interactions with the GBM; a rather stationary podocyte phenotype is believed to reflect a stable FP structure with intact slit diaphragms, whereas hypermotility is believed to promote the development of FP effacement and proteinuria" [MGI:anna]
Show

Allelic Composition: Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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