ENSMUSG00000020473


Mus musculus

Features
Gene ID: ENSMUSG00000020473
  
Biological name :Aebp1
  
Synonyms : Adipocyte enhancer-binding protein 1 / Aebp1 / Q640N1
  
Possible biological names infered from orthology : AE binding protein 1 / Q8IUX7
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A1
Gene start: 5861947
Gene end: 5872088
  
Corresponding Affymetrix probe sets: 10374083 (MoGene1.0st)   1422514_at (Mouse Genome 430 2.0 Array)   1450637_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099987
Ensembl peptide - ENSMUSP00000105454
NCBI entrez gene - 11568     See in Manteia.
MGI - MGI:1197012
RefSeq - NM_001291857
RefSeq - NM_009636
RefSeq Peptide - NP_001278786
RefSeq Peptide - NP_033766
swissprot - Q640N1
Ensembl - ENSMUSG00000020473
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aebp1ENSDARG00000091726Danio rerio
 si:ch1073-459j12.1ENSDARG00000006901Danio rerio
 AEBP1ENSGALG00000041834Gallus gallus
 AEBP1ENSG00000106624Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cpxm2 / carboxypeptidase X, M14 family member 2 / Q8N436*ENSMUSG0000003086235
Cpxm1 / Q9Z100 / Probable carboxypeptidase X1 / Q96SM3* / carboxypeptidase X, M14 family member 1*ENSMUSG0000002740832
Cpd / O89001 / Carboxypeptidase D / O75976*ENSMUSG0000002084121
Cpz / Q8R4V4 / carboxypeptidase Z / Q66K79*ENSMUSG0000003659618
Cpn1 / Q9JJN5 / carboxypeptidase N, polypeptide 1 / P15169* / carboxypeptidase N subunit 1*ENSMUSG0000002519616
Cpe / Q00493 / Carboxypeptidase E / P16870*ENSMUSG0000003785216
Cpm / Q80V42 / carboxypeptidase M / P14384*ENSMUSG0000002018312


Protein motifs (from Interpro)
Interpro ID Name
 IPR000421  Coagulation factor 5/8 C-terminal domain
 IPR000834  Peptidase M14, carboxypeptidase A
 IPR008969  Carboxypeptidase-like, regulatory domain superfamily
 IPR008979  Galactose-binding-like domain superfamily
 IPR034243  AEBP1/CPX, carboxypeptidase domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006518 peptide metabolic process IBA
 biological_processGO:0016485 protein processing IBA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0031012 extracellular matrix ISO
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0004180 carboxypeptidase activity IDA
 molecular_functionGO:0004181 metallocarboxypeptidase activity IBA
 molecular_functionGO:0004185 serine-type carboxypeptidase activity IBA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
Show

Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000757 herniated abdominal wall "protrusions through and/or into the abdominal wall often resulting in the extrusion of viscera" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
Show

Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Mc4rm1Btlr/Mc4rm1Btlr
Genetic Background: C57BL/6J-Mc4rm1Btlr

 MP:0001382 abnormal nursing "females do not nurse pups or nurse pups infrequently" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mc4rm1Btlr/Mc4rm1Btlr
Genetic Background: C57BL/6J-Mc4rm1Btlr

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mc4rm1Btlr/Mc4rm1Btlr
Genetic Background: C57BL/6J-Mc4rm1Btlr

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mc4rm1Btlr/Mc4rm1Btlr
Genetic Background: C57BL/6J-Mc4rm1Btlr

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mc4rm1Btlr/Mc4rm1Btlr
Genetic Background: C57BL/6J-Mc4rm1Btlr

 MP:0002970 abnormal white fat morphology "structural aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mc4rm1Btlr/Mc4rm1Btlr
Genetic Background: C57BL/6J-Mc4rm1Btlr

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mc4rm1Btlr/Mc4rm1Btlr
Genetic Background: C57BL/6J-Mc4rm1Btlr

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Mc4rm1Btlr/Mc4rm1Btlr
Genetic Background: C57BL/6J-Mc4rm1Btlr

 MP:0006271 abnormal involution of the mammary gland "anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mc4rm1Btlr/Mc4rm1Btlr
Genetic Background: C57BL/6J-Mc4rm1Btlr

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009115 abnormal fat cell morphology "any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
Show

Allelic Composition: Mc4rm1Btlr/Mc4rm1Btlr
Genetic Background: C57BL/6J-Mc4rm1Btlr

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mc4rm1Btlr/Mc4rm1Btlr
Genetic Background: C57BL/6J-Mc4rm1Btlr

Allelic Composition: Aebp1tm1Hsro/Aebp1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Mc4rm1Btlr/Mc4rm1Btlr
Genetic Background: C57BL/6J-Mc4rm1Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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