ENSMUSG00000020525


Mus musculus

Features
Gene ID: ENSMUSG00000020525
  
Biological name :Ppm1d
  
Synonyms : Ppm1d / Protein phosphatase 1D / Q9QZ67
  
Possible biological names infered from orthology : O15297 / protein phosphatase, Mg2+/Mn2+ dependent 1D
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: C
Gene start: 85311244
Gene end: 85347066
  
Corresponding Affymetrix probe sets: 10379891 (MoGene1.0st)   1434142_at (Mouse Genome 430 2.0 Array)   1449092_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115606
Ensembl peptide - ENSMUSP00000020835
NCBI entrez gene - 53892     See in Manteia.
MGI - MGI:1858214
RefSeq - NM_016910
RefSeq Peptide - NP_058606
swissprot - B1B0B1
swissprot - Q9QZ67
Ensembl - ENSMUSG00000020525
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppm1daENSDARG00000009273Danio rerio
 ppm1dbENSDARG00000021380Danio rerio
 PPM1DENSGALG00000035610Gallus gallus
 PPM1DENSG00000170836Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ppm1g / Q61074 / Protein phosphatase 1G / O15355* / protein phosphatase, Mg2+/Mn2+ dependent 1G*ENSMUSG0000002914715


Protein motifs (from Interpro)
Interpro ID Name
 IPR000222  PPM-type phosphatase, divalent cation binding
 IPR001932  PPM-type phosphatase domain
 IPR015655  Protein phosphatase 2C family
 IPR036457  PPM-type phosphatase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IMP
 biological_processGO:0006306 DNA methylation IDA
 biological_processGO:0006342 chromatin silencing IDA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0009267 cellular response to starvation IEA
 biological_processGO:0009617 response to bacterium IMP
 biological_processGO:0035970 peptidyl-threonine dephosphorylation IEA
 biological_processGO:0045814 negative regulation of gene expression, epigenetic IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISS
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IEA
 molecular_functionGO:0004724 magnesium-dependent protein serine/threonine phosphatase activity ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0043169 cation binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IEA


Pathways (from Reactome)
Pathway description
Transcriptional regulation by RUNX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000688 lymphoid hyperplasia "increased cell number in lymphatic tissues" [J:62478]
Show

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
Show

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
Show

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
Show

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Ppm1dtm1Lad/Ppm1dtm1Lad,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129 * C57BL * FVB/N * SJL

Allelic Composition: Ppm1dtm1Lad/Ppm1dtm1Lad,Tg(IghMyc)22Bri/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129 * C57BL * FVB/N * SJL

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ppm1dtm1Lad/Ppm1d+,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL * FVB/N * SJL

Allelic Composition: Ppm1dtm1Lad/Ppm1dtm1Lad,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL * FVB/N * SJL

Allelic Composition: Mapk14tm1.1Dvb/Mapk14+,Ppm1dtm1Lad/Ppm1dtm1Lad,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL * FVB/N * SJL

Allelic Composition: Cdkn2atm1Cjs/Cdkn2a+,Ppm1dtm1Lad/Ppm1dtm1Lad,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129 * C57BL * FVB/N * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Ppm1dtm1Lad/Ppm1d+,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL * FVB/N * SJL

Allelic Composition: Ppm1dtm1Lad/Ppm1dtm1Lad,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL * FVB/N * SJL

Allelic Composition: Mapk14tm1.1Dvb/Mapk14+,Ppm1dtm1Lad/Ppm1dtm1Lad,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL * FVB/N * SJL

Allelic Composition: Cdkn2atm1Cjs/Cdkn2a+,Ppm1dtm1Lad/Ppm1dtm1Lad,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129 * C57BL * FVB/N * SJL

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Ppm1dtm1Lad/Ppm1dtm1Lad,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129 * C57BL * FVB/N * SJL

Allelic Composition: Ppm1dtm1Lad/Ppm1dtm1Lad,Tg(IghMyc)22Bri/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129 * C57BL * FVB/N * SJL

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002499 chronic inflammation "persistent inflammatory response, often caused by persistent infection or during an autoimmune response" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rps7Zma/Rps7+,Tg(Dct-lacZ)IPav/0
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J * FVB/N

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011820 decreased pancreatic beta cell proliferation "reduction in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169]
Show

Allelic Composition: Rps7Zma/Rps7+,Tg(Dct-lacZ)IPav/0
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031885 Cbfb / Q08024 / Core-binding factor subunit beta / Q13951* / core-binding factor beta subunit*  / reaction
 ENSMUSG00000039153 Runx2 / Q08775 / runt related transcription factor 2 / Q13950*  / reaction






 

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