ENSMUSG00000020657


Mus musculus

Features
Gene ID: ENSMUSG00000020657
  
Biological name :Dnajc27
  
Synonyms : Dnajc27 / DnaJ homolog subfamily C member 27 / Q8CFP6
  
Possible biological names infered from orthology : DnaJ heat shock protein family (Hsp40) member C27 / Q9NZQ0
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A1.1
Gene start: 4082583
Gene end: 4110606
  
Corresponding Affymetrix probe sets: 10394245 (MoGene1.0st)   1434946_at (Mouse Genome 430 2.0 Array)   1435117_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020986
Ensembl peptide - ENSMUSP00000106803
Ensembl peptide - ENSMUSP00000151848
NCBI entrez gene - 217378     See in Manteia.
MGI - MGI:2443036
RefSeq - NM_153082
RefSeq - XM_006515052
RefSeq Peptide - NP_694722
swissprot - Q8CFP6
Ensembl - ENSMUSG00000020657
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6IMK3ENSDARG00000070916Danio rerio
 Q6IMM1ENSGALG00000028967Gallus gallus
 Q9NZQ0ENSG00000115137Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rab21 / P35282 / RAB21, member RAS oncogene family / Q9UL25*ENSMUSG0000002013223
Rab5c / P35278 / RAB5C, member RAS oncogene family / P51148*ENSMUSG0000001917322
Rab5b / P61021 / RAB5B, member RAS oncogene family / P61020*ENSMUSG0000000071121
Rab5a / Q9CQD1 / Ras-related protein Rab-5A / P20339* / RAB5A, member RAS oncogene family*ENSMUSG0000001783121
Rab17 / P35292 / Ras-related protein Rab-17 / Q9H0T7* / RAB17, member RAS oncogene family*ENSMUSG0000002630421
Rab31 / RAB31, member RAS oncogene family / Q13636*ENSMUSG0000005651521
P35285 / Rab22a / RAB22A, member RAS oncogene family / Q9UL26*ENSMUSG0000002751920
Rab20 / P35295 / Ras-related protein Rab-20 / Q9NX57* / RAB20, member RAS oncogene family*ENSMUSG0000003150416


Protein motifs (from Interpro)
Interpro ID Name
 IPR001623  DnaJ domain
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036869  Chaperone J-domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0043410 positive regulation of MAPK cascade IDA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0071701 regulation of MAPK export from nucleus IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005739 mitochondrion IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Pax5tm3Mbu/Pax5+,Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax5tm3Mbu/Pax5+,Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax5tm3Mbu/Pax5+,Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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