ENSMUSG00000020676


Mus musculus

Features
Gene ID: ENSMUSG00000020676
  
Biological name :Ccl11
  
Synonyms : Ccl11 / Eotaxin / P48298
  
Possible biological names infered from orthology : C-C motif chemokine ligand 11 / P51671
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: C
Gene start: 82057823
Gene end: 82062955
  
Corresponding Affymetrix probe sets: 10379524 (MoGene1.0st)   1417789_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000342
NCBI entrez gene - 20292     See in Manteia.
MGI - MGI:103576
RefSeq - NM_011330
RefSeq Peptide - NP_035460
swissprot - P48298
Ensembl - ENSMUSG00000020676
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CCL11ENSG00000172156Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ccl12 / Q62401 / C-C motif chemokine 12 / CCL8* / P80075* / C-C motif chemokine ligand 8*ENSMUSG0000003535249
Ccl2 / P10148 / C-C motif chemokine 2 / P13500* / C-C motif chemokine ligand 2*ENSMUSG0000003538549
Ccl7 / Q03366 / C-C motif chemokine 7 / P80098* / C-C motif chemokine ligand 7*ENSMUSG0000003537346
Ccl8 / Q9Z121 / C-C motif chemokine 8 / P80075* / C-C motif chemokine ligand 8*ENSMUSG0000000918541
Ccl24 / Q9JKC0 / C-C motif chemokine 24 / O00175* / C-C motif chemokine ligand 24*ENSMUSG0000000481432


Protein motifs (from Interpro)
Interpro ID Name
 IPR000827  CC chemokine, conserved site
 IPR001811  Chemokine interleukin-8-like domain
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0002544 chronic inflammatory response IEA
 biological_processGO:0002548 monocyte chemotaxis IBA
 biological_processGO:0002551 mast cell chemotaxis IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IBA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030593 neutrophil chemotaxis IBA
 biological_processGO:0030838 positive regulation of actin filament polymerization IEA
 biological_processGO:0035962 response to interleukin-13 IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0048245 eosinophil chemotaxis IEA
 biological_processGO:0048247 lymphocyte chemotaxis IBA
 biological_processGO:0060444 branching involved in mammary gland duct morphogenesis IMP
 biological_processGO:0060763 mammary duct terminal end bud growth IMP
 biological_processGO:0070098 chemokine-mediated signaling pathway IBA
 biological_processGO:0070371 ERK1 and ERK2 cascade IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:0070670 response to interleukin-4 IEA
 biological_processGO:0071346 cellular response to interferon-gamma IBA
 biological_processGO:0071347 cellular response to interleukin-1 IBA
 biological_processGO:0071356 cellular response to tumor necrosis factor IBA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0008009 chemokine activity IBA
 molecular_functionGO:0031728 CCR3 chemokine receptor binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0048018 receptor ligand activity IEA
 molecular_functionGO:0048020 CCR chemokine receptor binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata1tm6Sho/Gata1tm6Sho
Genetic Background: involves: 129S1/Sv * BALB/c

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer
Genetic Background: 129S.129S6-Ccl11tm1Mer

Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: involves: 129S6/SvEvTac

 MP:0008723 impaired eosinophil recruitment "reduced diffusion or accumulation of eosinophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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