ENSMUSG00000020695


Mus musculus

Features
Gene ID: ENSMUSG00000020695
  
Biological name :Mrc2
  
Synonyms : C-type mannose receptor 2 / Mrc2 / Q64449
  
Possible biological names infered from orthology : mannose receptor C type 2 / Q9UBG0
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E1
Gene start: 105292643
Gene end: 105351139
  
Corresponding Affymetrix probe sets: 10381898 (MoGene1.0st)   1421044_at (Mouse Genome 430 2.0 Array)   1421045_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000097909
Ensembl peptide - ENSMUSP00000021038
NCBI entrez gene - 17534     See in Manteia.
MGI - MGI:107818
RefSeq - NM_008626
RefSeq - XM_006532406
RefSeq Peptide - NP_032652
swissprot - A2AAA9
swissprot - Q64449
Ensembl - ENSMUSG00000020695
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mrc2ENSDARG00000078135Danio rerio
 MRC2ENSGALG00000000461Gallus gallus
 MRC2ENSG00000011028Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mrc1 / Q61830 / mannose receptor, C type 1 / P22897*ENSMUSG0000002671233
Pla2r1 / Q62028 / Secretory phospholipase A2 receptor Soluble secretory phospholipase A2 receptor / Q13018* / phospholipase A2 receptor 1*ENSMUSG0000005458032
Ly75 / Q60767 / Lymphocyte antigen 75 / O60449* / LY75-CD302* / LY75-CD302 readthrough*ENSMUSG0000002698030


Protein motifs (from Interpro)
Interpro ID Name
 IPR000562  Fibronectin type II domain
 IPR000772  Ricin B, lectin domain
 IPR001304  C-type lectin-like
 IPR013806  Kringle-like fold
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR018378  C-type lectin, conserved site
 IPR033989  CD209-like, C-type lectin-like domain
 IPR035992  Ricin B-like lectins
 IPR036943  Fibronectin type II domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0030574 collagen catabolic process IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IBA
 molecular_functionGO:0005518 collagen binding IEA
 molecular_functionGO:0030246 carbohydrate binding IEA


Pathways (from Reactome)
Pathway description
Cross-presentation of soluble exogenous antigens (endosomes)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gusbmps/Gusbmps
Genetic Background: involves: C57BL/6By

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nr4a2tm1Tpe/Nr4a2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011708 decreased fibroblast cell migration "reduced frequency of or less rapid cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith]
Show

Allelic Composition: Mrc1tm1Mnz/Mrc1tm1Mnz,Mrc2tm1Cmi/Mrc2tm1Cmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr