ENSMUSG00000020720


Mus musculus

Features
Gene ID: ENSMUSG00000020720
  
Biological name :Psmd12
  
Synonyms : proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 / Psmd12 / Q9D8W5
  
Possible biological names infered from orthology : O00232 / proteasome 26S subunit, non-ATPase 12
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E1
Gene start: 107479484
Gene end: 107504362
  
Corresponding Affymetrix probe sets: 10382139 (MoGene1.0st)   1448492_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102363
Ensembl peptide - ENSMUSP00000021063
Ensembl peptide - ENSMUSP00000102361
NCBI entrez gene - 66997     See in Manteia.
MGI - MGI:1914247
RefSeq - NM_025894
RefSeq Peptide - NP_080170
swissprot - B1AT36
swissprot - Q3TRH2
swissprot - Q9D8W5
Ensembl - ENSMUSG00000020720
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psmd12ENSDARG00000052377Danio rerio
 PSMD12ENSGALG00000026225Gallus gallus
 O00232ENSG00000197170Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000717  Proteasome component (PCI) domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR035297  26S Proteasome non-ATPase regulatory subunit 12
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 cellular_componentGO:0000502 proteasome complex ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005838 proteasome regulatory particle IDA
 cellular_componentGO:0008541 proteasome regulatory particle, lid subcomplex IBA
 cellular_componentGO:0022624 proteasome accessory complex IDA
 cellular_componentGO:0031595 nuclear proteasome complex IBA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
AUF1 (hnRNP D0) binds and destabilizes mRNA
ABC-family proteins mediated transport
Antigen processing: Ubiquitination & Proteasome degradation
Activation of NF-kappaB in B cells
Asymmetric localization of PCP proteins
CDK-mediated phosphorylation and removal of Cdc6
CLEC7A (Dectin-1) signaling
Degradation of DVL
Degradation of GLI1 by the proteasome
Cross-presentation of soluble exogenous antigens (endosomes)
Degradation of beta-catenin by the destruction complex
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Downstream TCR signaling
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
Interleukin-1 signaling
MAPK6/MAPK4 signaling
Neddylation
Orc1 removal from chromatin
Neutrophil degranulation
Regulation of PTEN stability and activity
Regulation of ornithine decarboxylase (ODC)
Regulation of RUNX2 expression and activity
Regulation of RAS by GAPs
SCF(Skp2)-mediated degradation of p27/p21
Regulation of RUNX3 expression and activity
TNFR2 non-canonical NF-kB pathway
Ub-specific processing proteases
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
UCH proteinases
Ubiquitin-dependent degradation of Cyclin D1
Separation of Sister Chromatids
NIK-->noncanonical NF-kB signaling
APC/C:Cdc20 mediated degradation of Securin
Autodegradation of the E3 ubiquitin ligase COP1
SCF-beta-TrCP mediated degradation of Emi1
Autodegradation of Cdh1 by Cdh1:APC/C
CDT1 association with the CDC6:ORC:origin complex
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
FCERI mediated NF-kB activation
Hedgehog ligand biogenesis
The role of GTSE1 in G2/M progression after G2 checkpoint
G2/M Checkpoints
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Dectin-1 mediated noncanonical NF-kB signaling
Degradation of AXIN
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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