ENSMUSG00000020776


Mus musculus
circulatinglevelFbf1increasedcelljunctioncholesteroldecreasedapicalassemblytotalglucosefas-bindingfactorprojectionorganizationciliumestablishmentepithelialpolarityspindlepolecytoplasmcentrosomecentriolecytoskeletoncomplexkeratinfilamentciliarytransition

Features
Gene ID: ENSMUSG00000020776
  
Biological name :Fbf1
  
Synonyms : A2A870 / Fas-binding factor 1 / Fbf1
  
Possible biological names infered from orthology : Q8TES7
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 116142285
Gene end: 116168166
  
Corresponding Affymetrix probe sets: 10393136 (MoGene1.0st)   1425979_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114893
Ensembl peptide - ENSMUSP00000099320
Ensembl peptide - ENSMUSP00000102043
Ensembl peptide - ENSMUSP00000114558
NCBI entrez gene - 217335     See in Manteia.
MGI - MGI:1922033
RefSeq - XM_006533096
RefSeq - XM_011248950
RefSeq - XM_011248951
RefSeq - XM_011248953
RefSeq - XM_017314491
RefSeq - NM_172571
RefSeq - XM_006533092
RefSeq - XM_006533093
RefSeq - XM_006533094
RefSeq - XM_006533097
RefSeq - XM_006533098
RefSeq - XM_006533099
RefSeq - XM_006533100
RefSeq - XM_006533101
RefSeq - XM_011248948
RefSeq - XM_011248949
RefSeq Peptide - NP_766159
swissprot - A2A872
swissprot - A2A870
swissprot - Z4YLK3
Ensembl - ENSMUSG00000020776
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FBF1ENSGALG00000002179Gallus gallus
 FBF1ENSG00000188878Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR033561  Fas-binding factor 1


Gene Ontology (GO)
cellular component organizationcellular component biogenesisestablishment or maintenance of cell polaritycellular component organizationcellular component biogenesisestablishment or maintenance of cell polaritycellular component organizationcellular component biogenesisestablishment or maintenance of cell polaritycellular component organizationcellular component biogenesisestablishment or maintenance of cell polaritycellular component organizationcellular component biogenesisestablishment or maintenance of cell polaritycellular component organizationcellular component biogenesisestablishment or maintenance of cell polaritycellular component organizationcellular component biogenesisestablishment or maintenance of cell polaritycellular component organizationcellular component biogenesisestablishment or maintenance of cell polaritycellular component organizationcellular component biogenesisestablishment or maintenance of cell polaritycellular component organizationcellular component biogenesisestablishment or maintenance of cell polaritycellular component organizationcellular component organizationcellular component biogenesiscellular component biogenesisestablishment or maintenance of cell polarityestablishment or maintenance of cell polarity
protein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein binding
cellorganellecell junctionsupramolecular complexprotein-containing complexcellorganellecell junctionsupramolecular complexprotein-containing complexcellorganellecell junctionsupramolecular complexprotein-containing complexcellorganellecell junctionsupramolecular complexprotein-containing complexcellorganellecell junctionsupramolecular complexprotein-containing complexcellorganellecell junctionsupramolecular complexprotein-containing complexcellorganellecell junctionsupramolecular complexprotein-containing complexcellorganellecell junctionsupramolecular complexprotein-containing complexcellorganellecell junctionsupramolecular complexprotein-containing complexcellorganellecell junctionsupramolecular complexprotein-containing complexcellcellorganelleorganellecell junctioncell junctionsupramolecular complexsupramolecular complexprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0043297 apical junction assembly ISO
 biological_processGO:0060271 cilium assembly ISO
 biological_processGO:0090162 establishment of epithelial cell polarity ISO
 cellular_componentGO:0000922 spindle pole ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005814 centriole ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043296 apical junction complex ISO
 cellular_componentGO:0045095 keratin filament ISO
 cellular_componentGO:0097539 ciliary transition fiber ISO
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Anchoring of the basal body to the plasma membrane


Phenotype (from MGI, Zfin or HPO)
limbs/digits/tail phenotypehomeostasis/metabolism phenotypeskeleton phenotypeimmune system phenotypehematopoietic system phenotypelimbs/digits/tail phenotypehomeostasis/metabolism phenotypeskeleton phenotypeimmune system phenotypehematopoietic system phenotypelimbs/digits/tail phenotypehomeostasis/metabolism phenotypeskeleton phenotypeimmune system phenotypehematopoietic system phenotypelimbs/digits/tail phenotypehomeostasis/metabolism phenotypeskeleton phenotypeimmune system phenotypehematopoietic system phenotypelimbs/digits/tail phenotypehomeostasis/metabolism phenotypeskeleton phenotypeimmune system phenotypehematopoietic system phenotypelimbs/digits/tail phenotypehomeostasis/metabolism phenotypeskeleton phenotypeimmune system phenotypehematopoietic system phenotypelimbs/digits/tail phenotypehomeostasis/metabolism phenotypeskeleton phenotypeimmune system phenotypehematopoietic system phenotypelimbs/digits/tail phenotypehomeostasis/metabolism phenotypeskeleton phenotypeimmune system phenotypehematopoietic system phenotypelimbs/digits/tail phenotypehomeostasis/metabolism phenotypeskeleton phenotypeimmune system phenotypehematopoietic system phenotypelimbs/digits/tail phenotypehomeostasis/metabolism phenotypeskeleton phenotypeimmune system phenotypehematopoietic system phenotypelimbs/digits/tail phenotypelimbs/digits/tail phenotypehomeostasis/metabolism phenohomeostasis/metabolism phenotypeskeleton phenotypeskeleton phenotypeimmune system phenotypeimmune system phenotypehematopoietic system phenotyhematopoietic system phenotype
IDPhenotypeDefinition Genetic BG
 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0003443 increased circulating glycerol level "higher than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0005296 abnormal humerus morphology "malformation of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0008806 increased circulating amylase level "greater concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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