ENSMUSG00000020978


Mus musculus

Features
Gene ID: ENSMUSG00000020978
  
Biological name :Klhdc2
  
Synonyms : Kelch domain-containing protein 2 / Klhdc2 / Q4G5Y1
  
Possible biological names infered from orthology : kelch domain containing 2 / Q9Y2U9
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: C2
Gene start: 69296681
Gene end: 69310687
  
Corresponding Affymetrix probe sets: 10396094 (MoGene1.0st)   1435020_at (Mouse Genome 430 2.0 Array)   1435086_s_at (Mouse Genome 430 2.0 Array)   1442596_at (Mouse Genome 430 2.0 Array)   1460678_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021362
NCBI entrez gene - 69554     See in Manteia.
MGI - MGI:1916804
RefSeq - NM_027117
RefSeq Peptide - NP_081393
swissprot - Q4G5Y1
Ensembl - ENSMUSG00000020978
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 klhdc2ENSDARG00000104864Danio rerio
 KLHDC2ENSGALG00000012244Gallus gallus
 KLHDC2ENSG00000165516Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Klhdc1 / Q80YG3 / Kelch domain-containing protein 1 / Q8N7A1* / kelch domain containing 1*ENSMUSG0000005189043
Hcfc1 / Q61191 / Host cell factor 1 HCF N-terminal chain 1 HCF N-terminal chain 2 HCF N-terminal chain 3 HCF N-terminal chain 4 HCF N-terminal chain 5 HCF N-terminal chain 6 HCF C-terminal c...ENSMUSG0000003138623
Hcfc2 / host cell factor C2 / Q9Y5Z7*ENSMUSG0000002024622
Q8VCH5 / Rabepk / Rab9 effector protein with kelch motifs / Q7Z6M1*ENSMUSG0000007095319
Lztr1 / Q9CQ33 / Mus musculus leucine-zipper-like transcriptional regulator, 1 (Lztr1), transcript variant 2, mRNA. / Q8N653* / leucine zipper like transcription regulator 1*ENSMUSG0000002276118
Q6PAR0 / Klhdc10 / Kelch domain-containing protein 10 / Q6PID8* / kelch domain containing 10*ENSMUSG0000002977517
Klhdc3 / kelch domain containing 3 / Q9BQ90*ENSMUSG0000006357617


Protein motifs (from Interpro)
Interpro ID Name
 IPR011043  Galactose oxidase/kelch, beta-propeller
 IPR015915  Kelch-type beta propeller


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008150 biological_process ND
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Kdm8tm1b(EUCOMM)Wtsi/Kdm8tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kdm8tm1b(EUCOMM)Wtsi/Ics

 MP:0000432 abnormal head morphology "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kdm8tm1b(EUCOMM)Wtsi/Kdm8tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kdm8tm1b(EUCOMM)Wtsi/Ics

 MP:0000443 abnormal snout morphology "anomalous structure or development of the anterior facial part of the muzzle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kdm8tm1b(EUCOMM)Wtsi/Kdm8tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kdm8tm1b(EUCOMM)Wtsi/Ics

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
Show

Allelic Composition: Kdm8tm1b(EUCOMM)Wtsi/Kdm8tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kdm8tm1b(EUCOMM)Wtsi/Ics

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Kdm8tm1b(EUCOMM)Wtsi/Kdm8tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kdm8tm1b(EUCOMM)Wtsi/Ics

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Kdm8tm1b(EUCOMM)Wtsi/Kdm8tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kdm8tm1b(EUCOMM)Wtsi/Ics

 MP:0011953 prolonged PQ interval "increase in the length of time between the beginning of atrial depolarization and the end of atrial repolarization (or recovery), measured by the interval from the beginning of the P wave to the end of the Q wave" [MPD:Molly]
Show

Allelic Composition: Kdm8tm1b(EUCOMM)Wtsi/Kdm8tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kdm8tm1b(EUCOMM)Wtsi/Ics

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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