Manteia

ENSMUSG00000020988

Mus musculus

Features

Gene ID:	ENSMUSG00000020988

Biological name :	L2hgdh

Synonyms :	L2hgdh / L-2-hydroxyglutarate dehydrogenase, mitochondrial / Q91YP0

Possible biological names infered from orthology :	L-2-hydroxyglutarate dehydrogenase / Q9H9P8

Species:	Mus musculus

Chr. number:	12
Strand:	-1
Band:	C2
Gene start:	69690433
Gene end:	69724873

Corresponding Affymetrix probe sets:	10400742 (MoGene1.0st) 10608676 (MoGene1.0st) 1424858_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000152394 Ensembl peptide - ENSMUSP00000021370 NCBI entrez gene - 217666 See in Manteia. MGI - MGI:2384968 RefSeq - NM_145443 RefSeq Peptide - NP_663418 swissprot - A0A1Y7VJE8 swissprot - Q91YP0 Ensembl - ENSMUSG00000020988

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
l2hgdh	ENSDARG00000060500	Danio rerio
L2HGDH	ENSGALG00000012282	Gallus gallus
L2HGDH	ENSG00000087299	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR006076	FAD dependent oxidoreductase
IPR036188	FAD/NAD(P)-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0044267	cellular protein metabolic process	IEA
biological_process	GO:0055114	oxidation-reduction process	IEA
cellular_component	GO:0005739	mitochondrion	ISS
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0016491	oxidoreductase activity	IEA
molecular_function	GO:0047545	2-hydroxyglutarate dehydrogenase activity	ISO

Pathways (from Reactome)

Pathway description

Interconversion of 2-oxoglutarate and 2-hydroxyglutarate

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000953	abnormal oligodendrocyte morphology	"anomalous structure, number or composition of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0002152	abnormal brain morphology	"anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0002574	increased vertical activity	"greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0002899	fatigue	"easily exhausted due to mental or physical exertion" [hdene:Howard Dene , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0002906	susceptibility to pharmacologically induced seizures	"inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0003634	abnormal glia	"malformation or absence of non-neuronal cells of the nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0003871	abnormal myelin sheath morphology	"malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0005332	abnormal amino acid level	"aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0008428	abnormal spatial working memory	"anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0011617	abnormal habituation	"anomaly in the process in which there is a progressive decline of behavioral response probability with a repetitive stimulus" [GO:0046959, PMID:16774787]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0012307	impaired spatial learning	"impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr