ENSMUSG00000021356


Mus musculus

Features
Gene ID: ENSMUSG00000021356
  
Biological name :Irf4
  
Synonyms : interferon regulatory factor 4 / Irf4 / Q64287
  
Possible biological names infered from orthology : Q15306
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A3.2
Gene start: 30749226
Gene end: 30766976
  
Corresponding Affymetrix probe sets: 10404389 (MoGene1.0st)   1421173_at (Mouse Genome 430 2.0 Array)   1421174_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021784
Ensembl peptide - ENSMUSP00000105936
Ensembl peptide - ENSMUSP00000152134
NCBI entrez gene - 16364     See in Manteia.
MGI - MGI:1096873
RefSeq - XM_006516560
RefSeq - NM_001347508
RefSeq - NM_013674
RefSeq Peptide - NP_001334437
RefSeq Peptide - NP_038702
swissprot - Q5SUZ4
swissprot - Q5SUZ5
swissprot - Q64287
swissprot - A0A1Y7VIT1
Ensembl - ENSMUSG00000021356
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irf4aENSDARG00000006560Danio rerio
 irf4bENSDARG00000055374Danio rerio
 ENSGALG00000043913Gallus gallus
 IRF4ENSGALG00000012830Gallus gallus
 IRF4ENSG00000137265Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Irf8 / P23611 / interferon regulatory factor 8 / Q02556*ENSMUSG0000004151541
Irf5 / P56477 / Interferon regulatory factor 5 / Q13568*ENSMUSG0000002977130
Irf9 / Q61179 / Interferon regulatory factor 9 / Q00978*ENSMUSG0000000232529
Irf6 / P97431 / Interferon regulatory factor 6 / O14896*ENSMUSG0000002663827
Irf3 / P70671 / interferon regulatory factor 3 / Q14653*ENSMUSG0000000318422
Irf7 / P70434 / interferon regulatory factor 7 / Q92985*ENSMUSG0000002549822
Irf2 / P23906 / interferon regulatory factor 2 / P14316*ENSMUSG0000003162717
Irf1 / P15314 / interferon regulatory factor 1 / P10914*ENSMUSG0000001889914


Protein motifs (from Interpro)
Interpro ID Name
 IPR001346  Interferon regulatory factor DNA-binding domain
 IPR008984  SMAD/FHA domain superfamily
 IPR017855  SMAD-like domain superfamily
 IPR019471  Interferon regulatory factor-3
 IPR019817  Interferon regulatory factor, conserved site
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006479 protein methylation IDA
 biological_processGO:0018022 peptidyl-lysine methylation IEA
 biological_processGO:0034122 negative regulation of toll-like receptor signaling pathway IMP
 biological_processGO:0042832 defense response to protozoan IMP
 biological_processGO:0043011 myeloid dendritic cell differentiation IMP
 biological_processGO:0043388 positive regulation of DNA binding IMP
 biological_processGO:0043966 histone H3 acetylation IMP
 biological_processGO:0043967 histone H4 acetylation IMP
 biological_processGO:0045082 positive regulation of interleukin-10 biosynthetic process ISO
 biological_processGO:0045086 positive regulation of interleukin-2 biosynthetic process ISS
 biological_processGO:0045368 positive regulation of interleukin-13 biosynthetic process ISO
 biological_processGO:0045404 positive regulation of interleukin-4 biosynthetic process ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0072540 T-helper 17 cell lineage commitment IMP
 cellular_componentGO:0000788 nuclear nucleosome IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016279 protein-lysine N-methyltransferase activity IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
Show

Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

Allelic Composition: Irf8tm1Hor/Irf8tm1Hor,Irf4tm1Mak/Irf4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpx3tm1Hjco/Gpx3tm1Hjco,Selenoptm1Rfb/Selenoptm1Rfb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Irf4m1Btlr/Irf4m1Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Irf4M2Btlr/Irf4M2Btlr
Genetic Background: C57BL/6J-Irf4M2Btlr

Allelic Composition: Irf4M2Btlr/Irf4+
Genetic Background: C57BL/6J-Irf4M2Btlr

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irf8tm1Hor/Irf8tm1Hor,Irf4tm1Mak/Irf4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Irf4m1Btlr/Irf4m1Btlr
Genetic Background: C57BL/6J-Irf4m1Btlr

Allelic Composition: Irf4m1Btlr/Irf4m1Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Irf4M2Btlr/Irf4M2Btlr
Genetic Background: C57BL/6J-Irf4M2Btlr

Allelic Composition: Irf4M2Btlr/Irf4+
Genetic Background: C57BL/6J-Irf4M2Btlr

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

Allelic Composition: Irf8tm1Hor/Irf8tm1Hor,Irf4tm1Mak/Irf4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Irf4tm1.1Rdf/Irf4tm1.1Rdf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0002166 altered tumor susceptibility/resistance "greater than or less than the average number of tumors, usually a specific type, arising in a given strain when compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

 MP:0002403 abnormal pre-B cell "anomalous structure, development, or number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Irf8tm1Hor/Irf8tm1Hor,Irf4tm1Mak/Irf4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

Allelic Composition: Irf4tm1Mak/Irf4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

 MP:0002440 abnormal memory B cell morphology/development "anomalous structure, differentiation, or number of cells of the B lymphocyte lineage that do not secrete antibody after an intitial contact with antigen, but can be rapidly activated after a second challenge with the same antigen" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irf4tm1.1Rdf/Irf4tm1.1Rdf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Scyl1mdf/Scyl1mdf
Genetic Background: involves: CFW * C57BL/6J * C57BR

Allelic Composition: Irf4tm1Rdf/Irf4tm1.1Rdf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

 MP:0003132 increased number of pre-B cells "greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Irf8tm1Hor/Irf8tm1Hor,Irf4tm1Mak/Irf4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Irf4tm1.1Rdf/Irf4tm1.1Rdf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Irf4m1Btlr/Irf4m1Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Col1a1tm1(tetO-Irf4)Sing/Col1a1tm1(tetO-Irf4)Sing,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+,Irf4tm1Mak/Irf4+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-Irf4)Sing/Col1a1tm1(tetO-Irf4)Sing,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+,Irf4tm1Mak/Irf4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Irf8tm1Hor/Irf8tm1Hor,Irf4tm1Mak/Irf4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irf8tm1Hor/Irf8tm1Hor,Irf4tm1Mak/Irf4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

Allelic Composition: Irf4tm1.1Rdf/Irf4tm1.1Rdf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008033 impaired lipolysis "reduction in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008071 absent B cells "absence of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irf8tm1Hor/Irf8tm1Hor,Irf4tm1Mak/Irf4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008088 abnormal T-helper 1 cell differentiation "atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

 MP:0008099 abnormal plasma cell differentiation "atypical production of or inability to produce terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-Irf4)Sing/Col1a1tm1(tetO-Irf4)Sing,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+,Irf4tm1Mak/Irf4+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-Irf4)Sing/Col1a1tm1(tetO-Irf4)Sing,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+,Irf4tm1Mak/Irf4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008100 absent plasma cells "absence of the terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

Allelic Composition: Ighg1tm1(cre)Cgn/Ighg1+,Irf4tm1Rdf/Irf4tm1.1Rdf
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0008124 decreased plasmacytoid dendritic cell number "reduced number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15596797]
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Allelic Composition: Irf4tm1Mak/Irf4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Irf8tm1Hor/Irf8tm1Hor,Irf4tm1Mak/Irf4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

Allelic Composition: Irf8tm1Hor/Irf8tm1Hor,Irf4tm1Mak/Irf4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irf4m1Btlr/Irf4m1Btlr
Genetic Background: C57BL/6J-Irf4m1Btlr

Allelic Composition: Irf4M2Btlr/Irf4M2Btlr
Genetic Background: C57BL/6J-Irf4M2Btlr

Allelic Composition: Irf4M2Btlr/Irf4+
Genetic Background: C57BL/6J-Irf4M2Btlr

 MP:0008474 absent spleen germinal center "absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

Allelic Composition: Irf4tm1.1Rdf/Irf4tm1.1Rdf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Irf4tm1.1Rdf/Irf4tm1.1Rdf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Ighg1tm1(cre)Cgn/Ighg1+,Irf4tm1Rdf/Irf4tm1.1Rdf
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0008523 absent lymph node germinal center "absence of the area of the lymph node secondary follicle where B cells are stimulated by antigens and helper T cells are stimulated to generate memory cells" [MESH:A10.549.400.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

 MP:0008964 decreased carbon dioxide production "reduction in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009118 increased white fat cell size "increase in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009288 increased epididymal fat pad weight 
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Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009292 increased inguinal fat pad weight 
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Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
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Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011014 decreased core body temperature "reduced degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011167 abnormal adipose tissue development "anomaly in the process of the formation of the connective tissue composed of fat cells enmeshed in areolar tissue" [MESH:A10.165.114, MGI:csmith]
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Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0014142 increased body fat mass "increased physical bulk or volume of fat in the whole body" [MGI:csmith]
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Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0014172 decreased fatty acid oxidation 
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Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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