ENSMUSG00000021363


Mus musculus

Features
Gene ID: ENSMUSG00000021363
  
Biological name :Mak
  
Synonyms : Mak / Q04859 / Serine/threonine-protein kinase MAK
  
Possible biological names infered from orthology : male germ cell associated kinase / P20794
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A3.3
Gene start: 41025008
Gene end: 41079706
  
Corresponding Affymetrix probe sets: 10408812 (MoGene1.0st)   1422724_at (Mouse Genome 430 2.0 Array)   1422725_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152961
Ensembl peptide - ENSMUSP00000152946
Ensembl peptide - ENSMUSP00000153176
Ensembl peptide - ENSMUSP00000153314
Ensembl peptide - ENSMUSP00000021792
Ensembl peptide - ENSMUSP00000064750
Ensembl peptide - ENSMUSP00000129615
NCBI entrez gene - 17152     See in Manteia.
MGI - MGI:96913
RefSeq - XM_006516873
RefSeq - NM_001145803
RefSeq - NM_008547
RefSeq - XM_006516868
RefSeq - XM_006516869
RefSeq - XM_006516870
RefSeq - XM_006516871
RefSeq - XM_006516872
RefSeq - NM_001145802
RefSeq Peptide - NP_032573
RefSeq Peptide - NP_001139274
RefSeq Peptide - NP_001139275
swissprot - A0A286YCF7
swissprot - Q04859
swissprot - A0A286YCX7
swissprot - A0A286YD80
Ensembl - ENSMUSG00000021363
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 makENSDARG00000059287Danio rerio
 MAKENSGALG00000012770Gallus gallus
 MAKENSG00000111837Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ick / Q9JKV2 / Serine/threonine-protein kinase ICK / Q9UPZ9* / intestinal cell kinase*ENSMUSG0000000982852
Mok / Q9WVS4 / MAPK/MAK/MRK overlapping kinase / Q9UQ07* / MOK protein kinase*ENSMUSG0000005645820


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0042073 intraciliary transport IBA
 biological_processGO:0045494 photoreceptor cell maintenance IMP
 biological_processGO:0046777 protein autophosphorylation ISS
 biological_processGO:1902856 negative regulation of non-motile cilium assembly IMP
 cellular_componentGO:0001750 photoreceptor outer segment IEA
 cellular_componentGO:0001917 photoreceptor inner segment ISS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005813 centrosome ISS
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0005930 axoneme IDA
 cellular_componentGO:0030496 midbody ISO
 cellular_componentGO:0031514 motile cilium IDA
 cellular_componentGO:0032391 photoreceptor connecting cilium IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0072686 mitotic spindle ISS
 cellular_componentGO:0097542 ciliary tip IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003713 transcription coactivator activity ISO
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata1tm6Sho/Y
Genetic Background: involves: 129S1/Sv

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata1tm6Sho/Y
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr