ENSMUSG00000021614


Mus musculus

Features
Gene ID: ENSMUSG00000021614
  
Biological name :Vcan
  
Synonyms : Vcan / versican
  
Possible biological names infered from orthology : P13611
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: C3
Gene start: 89655312
Gene end: 89742509
  
Corresponding Affymetrix probe sets: 10410931 (MoGene1.0st)   1421694_a_at (Mouse Genome 430 2.0 Array)   1427256_at (Mouse Genome 430 2.0 Array)   1427257_at (Mouse Genome 430 2.0 Array)   1433043_at (Mouse Genome 430 2.0 Array)   1433044_at (Mouse Genome 430 2.0 Array)   1447586_at (Mouse Genome 430 2.0 Array)   1447887_x_at (Mouse Genome 430 2.0 Array)   1459767_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125446
Ensembl peptide - ENSMUSP00000125432
Ensembl peptide - ENSMUSP00000125521
Ensembl peptide - ENSMUSP00000125694
Ensembl peptide - ENSMUSP00000125674
Ensembl peptide - ENSMUSP00000105170
Ensembl peptide - ENSMUSP00000105171
Ensembl peptide - ENSMUSP00000105173
NCBI entrez gene - 13003     See in Manteia.
MGI - MGI:102889
RefSeq - XM_011244470
RefSeq - NM_001081249
RefSeq - NM_001134474
RefSeq - NM_001134475
RefSeq - NM_019389
RefSeq - NM_172955
RefSeq Peptide - NP_766543
RefSeq Peptide - NP_001127947
RefSeq Peptide - NP_062262
RefSeq Peptide - NP_001074718
RefSeq Peptide - NP_001127946
swissprot - F7B603
swissprot - F7B6F7
swissprot - E9PYH0
swissprot - G3XA35
swissprot - Q8BS97
swissprot - E0CZC0
swissprot - E9QMK3
swissprot - E9QMK2
Ensembl - ENSMUSG00000021614
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vcanaENSDARG00000103515Danio rerio
 vcanbENSDARG00000009401Danio rerio
 VCANENSGALG00000015624Gallus gallus
 VCANENSG00000038427Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Acan / Q61282 / Aggrecan core protein / aggrecan*ENSMUSG0000003060717
Ncan / neurocan / O14594*ENSMUSG0000000234112
Bcan / Q61361 / Brevican core protein / Q96GW7* / brevican*ENSMUSG0000000489210
Stab2 / Q8R4U0 / Stabilin-2 Short form stabilin-2 / Q8WWQ8* / stabilin 2*ENSMUSG000000354597
Stab1 / stabilin 1 / Q9NY15*ENSMUSG000000422867
Hapln4 / Q80WM4 / Hyaluronan and proteoglycan link protein 4 / Q86UW8*ENSMUSG000000075944
Hapln1 / Q9QUP5 / Hyaluronan and proteoglycan link protein 1 / P10915*ENSMUSG000000216134
Hapln3 / Q80WM5 / Hyaluronan and proteoglycan link protein 3 / Q96S86*ENSMUSG000000306064
Hapln2 / Q9ESM3 / hyaluronan and proteoglycan link protein 2 / Q9GZV7*ENSMUSG000000048943
O08859 / Tnfaip6 / tumor necrosis factor alpha induced protein 6 / P98066* / TNF alpha induced protein 6*ENSMUSG000000534752


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000436  Sushi/SCR/CCP domain
 IPR000538  Link domain
 IPR000742  EGF-like domain
 IPR001304  C-type lectin-like
 IPR001881  EGF-like calcium-binding domain
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013032  EGF-like, conserved site
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR018097  EGF-like calcium-binding, conserved site
 IPR018378  C-type lectin, conserved site
 IPR033987  Aggrecan/versican, C-type lectin-like domain
 IPR035976  Sushi/SCR/CCP superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005540 hyaluronic acid binding IEA


Pathways (from Reactome)
Pathway description
A tetrasaccharide linker sequence is required for GAG synthesis
Chondroitin sulfate biosynthesis
Dermatan sulfate biosynthesis
CS/DS degradation
ECM proteoglycans
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Vcantm2Hwat/Vcantm2Hwat
Genetic Background: B6.Cg-Vcantm2Hwat

 MP:0000298 absent endocardial cushion "absence of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [MGI:CLS]
Show

Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0000301 reduced size of endocardial cushions "smaller than normal mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
Show

Allelic Composition: Vcantm2Hwat/Vcantm2Hwat
Genetic Background: B6.Cg-Vcantm2Hwat

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
Show

Allelic Composition: Hprttm1(tetO-Runx1,-EGFP)Enk/Hprt+,Sox10tm2(rtTA)Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Adamts9tm1Dgen/Adamts9tm1Dgen,VcanTg(Hoxa1)1Chm/Vcan+
Genetic Background: B6.Cg-Adamts9tm1Dgen VcanTg(Hoxa1)1Chm

 MP:0000571 interdigital webbing "fold of skin, or web, between the toes that is not normally present" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Adamts20bt-Bei1/Adamts20+,Adamts5tm1Dgen/Adamts5tm1Dgen,Adamts9tm1Dgen/Adamts9+
Genetic Background: B6.Cg-Adamts9tm1Dgen Adamts20bt-Bei1 Adamts5tm1Dgen

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hprttm1(tetO-Runx1,-EGFP)Enk/Hprt+,Sox10tm2(rtTA)Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Vcantm2Hwat/Vcantm2Hwat
Genetic Background: B6.Cg-Vcantm2Hwat

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Vcantm2Hwat/Vcantm2Hwat
Genetic Background: B6.Cg-Vcantm2Hwat

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hprttm1(tetO-Runx1,-EGFP)Enk/Hprt+,Sox10tm2(rtTA)Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hprttm1(tetO-Runx1,-EGFP)Enk/Hprt+,Sox10tm2(rtTA)Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0003920 abnormal right ventricle morphology "structural anomaly of the right lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vcantm2Hwat/Vcantm2Hwat
Genetic Background: B6.Cg-Vcantm2Hwat

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0005306 abnormal phalanx morphology "aberrant structure of any of the long bones of the digits" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hprttm1(tetO-Runx1,-EGFP)Enk/Hprt+,Sox10tm2(rtTA)Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Man2a1tm1Jxm/Man2a1tm1Jxm,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129-Rag1tm1Mom Man2a1tm1Jxm

 MP:0009780 abnormal chondrocyte physiology "any functional anomaly of nondividing cartilage cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hprttm1(tetO-Runx1,-EGFP)Enk/Hprt+,Sox10tm2(rtTA)Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Vcantm2Hwat/Vcantm2Hwat
Genetic Background: B6.Cg-Vcantm2Hwat

 MP:0010586 absent conotruncal ridges "absence of the pair of spiral mesenchymal swellings in the primordial ventricular outflow tract, that eventually fuse to form the conotruncal septum, dividing the subvalvular outflow tract and contributing to the membranous interventricular septum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8823298]
Show

Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Vcantm2Hwat/Vcantm2Hwat
Genetic Background: B6.Cg-Vcantm2Hwat

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

Allelic Composition: Vcantm2Hwat/Vcantm2Hwat
Genetic Background: B6.Cg-Vcantm2Hwat

Allelic Composition: Vcantm2Hwat/Vcantm2Hwat
Genetic Background: involves: 129 * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Vcantm2Hwat/Vcantm2Hwat
Genetic Background: B6.Cg-Vcantm2Hwat

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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