ENSMUSG00000021806


Mus musculus

Features
Gene ID: ENSMUSG00000021806
  
Biological name :Nid2
  
Synonyms : Nid2 / Nidogen-2 / O88322
  
Possible biological names infered from orthology : Q14112
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: A3
Gene start: 19751265
Gene end: 19811787
  
Corresponding Affymetrix probe sets: 10412921 (MoGene1.0st)   1423516_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153102
Ensembl peptide - ENSMUSP00000022340
NCBI entrez gene - 18074     See in Manteia.
MGI - MGI:1298229
RefSeq - NM_008695
RefSeq Peptide - NP_032721
swissprot - A0A286YCQ5
swissprot - O88322
Ensembl - ENSMUSG00000021806
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nid2aENSDARG00000075707Danio rerio
 nid2bENSDARG00000009471Danio rerio
 NID2ENSGALG00000012394Gallus gallus
 NID2ENSG00000087303Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nid1 / P10493 / Nidogen-1 / P14543*ENSMUSG0000000539739
Egf / P01132 / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01133* / epidermal growth factor*ENSMUSG0000002801713


Protein motifs (from Interpro)
Interpro ID Name
 IPR000033  LDLR class B repeat
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000716  Thyroglobulin type-1
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR003886  NIDO domain
 IPR006605  G2 nidogen/fibulin G2F
 IPR009017  Green fluorescent protein
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR036857  Thyroglobulin type-1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion IPI
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005604 basement membrane ISO
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Laminin interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Brca1tm3Cxd/Brca1tm3Cxd
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0003200 joint calcification "pathologic deposition of calcium salts in the joints" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Brca1tm3Cxd/Brca1tm3Cxd
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0003560 osteoarthritis "a type of arthritis that is caused by the breakdown and eventual loss of the cartilage of one or more joints" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95374]
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Allelic Composition: Brca1tm3Cxd/Brca1tm3Cxd
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Fcgr1tm1Jgjw/Fcgr1tm1Jgjw
Genetic Background: involves: 129 * C57BL/6

 MP:0006429 abnormal hyaline cartilage morphology "any structural anomaly of the bluish-white, glassy, translucent nonvascular, resilient, flexible connective tissue; found primarily in articular cartilage, costal cartilages, the nasal septum, the larynx, and the trachea" [ISBN:0-8036-0655-9 "Taber s Cyclopedic Medical Dictionary", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brca1tm3Cxd/Brca1tm3Cxd
Genetic Background: involves: 129S6/SvEvTac * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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