ENSMUSG00000022184


Mus musculus

Features
Gene ID: ENSMUSG00000022184
  
Biological name :Fbxo4
  
Synonyms : F-box only protein 4 / Fbxo4 / Q8CHQ0
  
Possible biological names infered from orthology : F-box protein 4 / Q9UKT5
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: A1
Gene start: 3965445
Gene end: 3979573
  
Corresponding Affymetrix probe sets: 10427420 (MoGene1.0st)   1421543_at (Mouse Genome 430 2.0 Array)   1427121_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022791
NCBI entrez gene - 106052     See in Manteia.
MGI - MGI:2146220
RefSeq - NM_134099
RefSeq Peptide - NP_598860
swissprot - Q8CHQ0
Ensembl - ENSMUSG00000022184
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fbxo4ENSDARG00000074170Danio rerio
 FBXO4ENSGALG00000014851Gallus gallus
 FBXO4ENSG00000151876Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001810  F-box domain
 IPR036047  F-box-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0000723 telomere maintenance ISS
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0007568 aging IMP
 biological_processGO:0010608 posttranscriptional regulation of gene expression IMP
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0019725 cellular homeostasis IMP
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination IEA
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0031648 protein destabilization IMP
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IEA
 biological_processGO:0035726 common myeloid progenitor cell proliferation IMP
 biological_processGO:0048147 negative regulation of fibroblast proliferation IMP
 biological_processGO:0071479 cellular response to ionizing radiation IDA
 biological_processGO:1900181 negative regulation of protein localization to nucleus IMP
 biological_processGO:1902916 positive regulation of protein polyubiquitination IMP
 biological_processGO:2000001 regulation of DNA damage checkpoint IMP
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA


Pathways (from Reactome)
Pathway description
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pdia3Gt(RST003)Byg/Pdia3Gt(RST003)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fbxo4tm1.1Jadi/Fbxo4tm1.1Jadi
Genetic Background: Not Specified

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Pdia3Gt(RST003)Byg/Pdia3Gt(RST003)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fbxo4tm1.1Jadi/Fbxo4tm1.1Jadi
Genetic Background: Not Specified

 MP:0002047 hepatic hemangioma "neoplastic- like masses in the liver; often undergoes spontaneous regression" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
Show

Allelic Composition: Pdia3Gt(RST003)Byg/Pdia3Gt(RST003)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fbxo4tm1.1Jadi/Fbxo4tm1.1Jadi
Genetic Background: Not Specified

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pdia3Gt(RST003)Byg/Pdia3Gt(RST003)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fbxo4tm1.1Jadi/Fbxo4tm1.1Jadi
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NCrj

 MP:0002947 hemangioma "proliferation of blood vessels leading to a mass that resembles a neoplasm" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87544]
Show

Allelic Composition: Pdia3Gt(RST003)Byg/Pdia3Gt(RST003)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fbxo4tm1.1Jadi/Fbxo4tm1.1Jadi
Genetic Background: Not Specified

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Pdia3Gt(RST003)Byg/Pdia3Gt(RST003)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fbxo4tm1.1Jadi/Fbxo4tm1.1Jadi
Genetic Background: Not Specified

 MP:0009222 uterus tumor "presence of abnormal rapidly proliferating cells in the uterus, usually in the form of a distinct mass" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdia3Gt(RST003)Byg/Pdia3Gt(RST003)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fbxo4tm1.1Jadi/Fbxo4tm1.1Jadi
Genetic Background: Not Specified

 MP:0009321 histiocytic sarcoma 
Show

Allelic Composition: Pdia3Gt(RST003)Byg/Pdia3Gt(RST003)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fbxo4tm1.1Jadi/Fbxo4tm1.1Jadi
Genetic Background: Not Specified

 MP:0009439 myeloid sarcoma "malignant tumor of immature myeloid cells, often associaed with or preceeding granulocytic leukemia" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Pdia3Gt(RST003)Byg/Pdia3Gt(RST003)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fbxo4tm1.1Jadi/Fbxo4tm1.1Jadi
Genetic Background: Not Specified

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdia3Gt(RST003)Byg/Pdia3Gt(RST003)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fbxo4tm1.1Jadi/Fbxo4tm1.1Jadi
Genetic Background: Not Specified

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdia3Gt(RST003)Byg/Pdia3Gt(RST003)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fbxo4tm1.1Jadi/Fbxo4tm1.1Jadi
Genetic Background: Not Specified

 MP:0011703 increased fibroblast proliferation "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Fbxo4tm1.1Jadi/Fbxo4tm1.1Jadi
Genetic Background: Not Specified

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Pdia3Gt(RST003)Byg/Pdia3Gt(RST003)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fbxo4tm1.1Jadi/Fbxo4tm1.1Jadi
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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