ENSMUSG00000022435


Mus musculus

Features
Gene ID: ENSMUSG00000022435
  
Biological name :Upk3a
  
Synonyms : Q9JKX8 / Upk3a / uroplakin 3A
  
Possible biological names infered from orthology : O75631
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: E2
Gene start: 85017141
Gene end: 85022547
  
Corresponding Affymetrix probe sets: 10425914 (MoGene1.0st)   1449104_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023070
NCBI entrez gene - 22270     See in Manteia.
MGI - MGI:98914
RefSeq - NM_023478
RefSeq Peptide - NP_075967
swissprot - Q9JKX8
Ensembl - ENSMUSG00000022435
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 UPK3AENSGALG00000014227Gallus gallus
 UPK3AENSG00000100373Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR024825  Uroplakin-3a
 IPR024831  Uroplakin-3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IMP
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0006833 water transport IMP
 biological_processGO:0015840 urea transport IMP
 biological_processGO:0030855 epithelial cell differentiation IEA
 biological_processGO:0055075 potassium ion homeostasis IMP
 biological_processGO:0055078 sodium ion homeostasis IMP
 biological_processGO:0060157 urinary bladder development IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
Show

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Nphs1-cre)1Seq/0
Genetic Background: involves: 129/Sv

 MP:0001948 vesicoureteral reflux "the retrograde flow of urine from the bladder into the ureters and kidneys" [J:77653, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Nphs1-cre)1Seq/0
Genetic Background: involves: 129/Sv

 MP:0003590 ureteral reflux "retrograde movement of urine from the bladder to the kidney" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Nphs1-cre)1Seq/0
Genetic Background: involves: 129/Sv

 MP:0003630 abnormal urothelium "malformation of the mucus lining in organs of the urinary tract, consisting in the bladder of three to seven cell layers" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95622]
Show

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Nphs1-cre)1Seq/0
Genetic Background: involves: 129/Sv

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Nphs1-cre)1Seq/0
Genetic Background: involves: 129/Sv

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Nphs1-cre)1Seq/0
Genetic Background: involves: 129/Sv

 MP:0009349 increased urine pH "increased urine alkalinity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Nphs1-cre)1Seq/0
Genetic Background: involves: 129/Sv

 MP:0010386 abnormal urinary bladder physiology "any functional anomaly of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Nphs1-cre)1Seq/0
Genetic Background: involves: 129/Sv

 MP:0011535 increased urination frequency "increased frequency of urination episodes; urination at short frequent intervals occurs without an increase in daily volume of urinary output and may be caused by reduced bladder capacity or urinary tract infection" [MGI:anna]
Show

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Nphs1-cre)1Seq/0
Genetic Background: involves: 129/Sv

 MP:0011783 abnormal ureteral orifice morphology "any structural anomaly of the slit-like opening of either ureter into the bladder; normally, the two ureteral orifices are placed at the posterolateral angles of the urinary bladder trigone while the internal urethral orifice is placed at its anteroinferior angle (apex); wide gaping usually indicates vesicoureteral reflux" [MGI:anna]
Show

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Nphs1-cre)1Seq/0
Genetic Background: involves: 129/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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