ENSMUSG00000022505


Mus musculus

Features
Gene ID: ENSMUSG00000022505
  
Biological name :Emp2
  
Synonyms : Emp2 / Epithelial membrane protein 2 / O88662
  
Possible biological names infered from orthology : P54851
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: A1
Gene start: 10281749
Gene end: 10313968
  
Corresponding Affymetrix probe sets: 10437639 (MoGene1.0st)   1425272_at (Mouse Genome 430 2.0 Array)   1425273_s_at (Mouse Genome 430 2.0 Array)   1433670_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077466
NCBI entrez gene - 13731     See in Manteia.
MGI - MGI:1098726
RefSeq - NM_007929
RefSeq Peptide - NP_031955
swissprot - O88662
swissprot - Q548I4
Ensembl - ENSMUSG00000022505
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 emp2ENSDARG00000044588Danio rerio
 EMP2ENSGALG00000027058Gallus gallus
 EMP2ENSG00000213853Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pmp22 / peripheral myelin protein 22 isoform 2 / Q01453* / peripheral myelin protein 22*ENSMUSG0000001821740
Emp1 / P47801 / Epithelial membrane protein 1 / P54849*ENSMUSG0000003020839
Emp3 / O35912 / Epithelial membrane protein 3 / P54852*ENSMUSG0000004021237


Protein motifs (from Interpro)
Interpro ID Name
 IPR003933  Epithelial membrane protein 2
 IPR004031  PMP-22/EMP/MP20/Claudin superfamily
 IPR004032  PMP-22/EMP/MP20


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001765 membrane raft assembly IDA
 biological_processGO:0001913 T cell mediated cytotoxicity IDA
 biological_processGO:0001952 regulation of cell-matrix adhesion IDA
 biological_processGO:0001954 positive regulation of cell-matrix adhesion IEA
 biological_processGO:0003093 regulation of glomerular filtration IEA
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007566 embryo implantation IMP
 biological_processGO:0008219 cell death IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010594 regulation of endothelial cell migration IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0032060 bleb assembly IEA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0034394 protein localization to cell surface IEA
 biological_processGO:0043534 blood vessel endothelial cell migration IEA
 biological_processGO:0043549 regulation of kinase activity IEA
 biological_processGO:0045022 early endosome to late endosome transport IDA
 biological_processGO:0045765 regulation of angiogenesis IEA
 biological_processGO:0070252 actin-mediated cell contraction IEA
 biological_processGO:0072659 protein localization to plasma membrane IDA
 biological_processGO:2001046 positive regulation of integrin-mediated signaling pathway ISO
 biological_processGO:2001212 regulation of vasculogenesis IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0045121 membrane raft ISO
 cellular_componentGO:0045177 apical part of cell IDA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Alms1tvrm102/Alms1Gt(XH152)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001711 abnormal placenta 
Show

Allelic Composition: Alms1tvrm102/Alms1Gt(XH152)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Alms1tvrm102/Alms1Gt(XH152)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Alms1tvrm102/Alms1Gt(XH152)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
Show

Allelic Composition: Alms1tvrm102/Alms1Gt(XH152)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009394 increased uterine NK cell number "increased number of the uterine subset of the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; uNK cells contribute to uterine decidualization and are recruited to implantation sites" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Alms1tvrm102/Alms1Gt(XH152)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0012529 abnormal decidua basalis morphology "any structural anomaly of the area of uterine endometrium found between the implanted chorionic vesicle and the myometrium; with continued growth of the embryo, the decidua basalis becomes incorporated into the maternal component of the definitive placenta" [MGI:anna]
Show

Allelic Composition: Alms1tvrm102/Alms1Gt(XH152)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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