ENSMUSG00000022667


Mus musculus

Features
Gene ID: ENSMUSG00000022667
  
Biological name :Cd200r1
  
Synonyms : Cd200r1 / Cell surface glycoprotein CD200 receptor 1 / Q9ES57
  
Possible biological names infered from orthology : CD200R1L / CD200 receptor 1 / CD200 receptor 1 like / Q6Q8B3 / Q8TD46
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B4
Gene start: 44765736
Gene end: 44794978
  
Corresponding Affymetrix probe sets: 10435907 (MoGene1.0st)   1422191_at (Mouse Genome 430 2.0 Array)   1439703_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000053822
Ensembl peptide - ENSMUSP00000138076
NCBI entrez gene - 57781     See in Manteia.
MGI - MGI:1889024
RefSeq - NM_021325
RefSeq Peptide - NP_067300
swissprot - M0QWY6
swissprot - Q9ES57
Ensembl - ENSMUSG00000022667
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000015191Gallus gallus
 Q2YHT7ENSGALG00000019231Gallus gallus
 Q6Q8B3ENSG00000206531Homo sapiens
 Q8TD46ENSG00000163606Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6XJV4 / Cd200r4 / Cell surface glycoprotein CD200 receptor 4 / Q8TD46* / Q6Q8B3* / CD200R1* / CD200R1L* / CD200 receptor 1* / CD200 receptor 1 like*ENSMUSG0000006208258
Q6XJV6 / Cd200r2 / Cell surface glycoprotein CD200 receptor 2 / Q8TD46* / Q6Q8B3* / CD200R1* / CD200R1L* / CD200 receptor 1* / CD200 receptor 1 like*ENSMUSG0000009017652
Q5UKY4 / Cd200r3 / Cell surface glycoprotein CD200 receptor 3 / Q8TD46* / Q6Q8B3* / CD200R1* / CD200R1L* / CD200 receptor 1* / CD200 receptor 1 like*ENSMUSG0000003617227


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013162  CD80-like, immunoglobulin C2-set
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex ISO
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Tpp1tm1Plob/Tpp1tm1Plob
Genetic Background: B6.129S1-Tpp1tm1Plob

Allelic Composition: Cd200r1tm1.1Rmgo/Cd200r1tm1.1Rmgo,Tg(tetO/CMV-CD200)1Rmgo/Tg(tetO/CMV-CD200)1Rmgo
Genetic Background: involves: C57BL/6

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: C.B6-Nlrp1aNeut1

 MP:0002452 abnormal antigen presenting cell physiology "impairment or abnormality of the function of cells involved in making antigen recognizable by lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tpp1tm1Plob/Tpp1tm1Plob
Genetic Background: B6.129S1-Tpp1tm1Plob

 MP:0005671 response to transplant "the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
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Allelic Composition: Tpp1tm1Plob/Tpp1tm1Plob
Genetic Background: B6.129S1-Tpp1tm1Plob

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Tpp1tm1Plob/Tpp1tm1Plob
Genetic Background: B6.129S1-Tpp1tm1Plob

 MP:0008565 decreased interferon-beta secretion "reduction in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
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Allelic Composition: Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: C.B6-Nlrp1aNeut1

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: C.B6-Nlrp1aNeut1

 MP:0008669 increased interleukin-12b secretion "increase in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
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Allelic Composition: Tpp1tm1Plob/Tpp1tm1Plob
Genetic Background: B6.129S1-Tpp1tm1Plob

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: C.B6-Nlrp1aNeut1

 MP:0009790 decreased susceptibility to viral infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: C.B6-Nlrp1aNeut1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022661 Cd200 / CD200 antigen / P41217* / CD200 molecule*  / complex / reaction






 

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